Relationships between oxidative stress and sleep parameters in patients with obstructive sleep apnea syndrome

Year 2014, Volume: 5 Issue: 2, 271 - 275, 01.06.2014

Özlem Abakay Hadice Selimoğlu Şen Hatice Yüksel Süreyya Yılmaz Yılmaz Palanci Abdullah Çetin Tanrıkulu Abdurrahman Abakay

https://doi.org/10.5799/ahinjs.01.2014.02.0401

Abstract

Objective: Oxidative stress is characterized byan imbalance between production and destruction of reactive oxygen species. In our study, we aimed to determine the relationship between the oxidant-antioxidant balance in patients with showing some biochemical factors reflecting the severity of the disease and sleep parameters in patients with Obstructive Sleep Apnea Syndrome (OSAS). Methods: 93 patients were included to the study at the sleep centre, Department of Chest Diseases, Dicle University Hospital. All patients were subjected to all night polysomnography. Serum TOS and TAS levels were measured. Results: The mean age of patients was 47.4±7.2 years. There was not significant between patient and control groups in terms of age, gender, body mass index and frequency of symptoms (p> 0.05).The mean apnea-hypopnea index (AHI) was 25.1units/hour. We found these parameters significant compared with the control group; apnea-hypopnea index, arousal index, oxygen desaturation index, serum total oxidant and serum total antioxidant level (p

Keywords

Obstructive Sleep Apnea Syndrome, oxidative stress, TAS, TOS.

Obstrüktif uyku apne sendromlu hastalarda uyku parametreleri ile oksidatif stres arasındaki ilişki

Abstract

Amaç: Oksidatif stress reaktif oksijen türevlerinin üretimi ve yıkılması arasındaki dengesizlik ile karakterizedir. Çalışmamızda Obstrüktif uyku apne sendromu (OUAS) hastalarında oksidan –antioksidan dengeyi gösteren bazı biyokimyasal faktörlerle hastalığın şiddetini yansıtan uyku parametreleri arasındaki ilişkiyi belirlemeyi amaçladık. Yöntemler: Çalışmaya Dicle Üniversitesi Tıp Fakültesi Göğüs Hastalıkları Uyku merkezinde Polisomnografi kaydı yapılan toplam 93 hasta alındı. Her olgu tüm gece polisomnografi işlemine tabi tutuldu. Serum total oksidan seviyesi (TOS) ve total antioksidan seviyesi (TAS) düzeyleri ölçüldü. Bulgular: Hastaların yaş ortalaması 47,4 ± 7,2 yıldı. Hasta ve kontrol grupları arasında yaş, cins, vücut kitle indeksi ve semptom sıklığı açısından anlamlı fark saptanmadı (p>0,05).Hastaların apne hipopne indeksi (AHİ) ortalaması 25,1 adet/saat idi. Hasta grubunda kontrol grubuna göre anlamlı olarak farklı bulunan parametreler; apne–hipopne indeksi, arrousal indeksi, oksijen desatürasyon indeksi, serum TOS ve serum TAS idi (p

Keywords

Obstrüktif Uyku Apne Sendromu, oksidatif stres, TAS, TOS

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