Comparison of the efficacy of esmolol and lidocaine in the control of hemodynamic response associated with intubation: A randomized controlled trial

Year 2013, Volume: 4 Issue: 1, 20 - 27, 01.03.2013

Tolga Ergönenç Jalan Şerbetçigil Uğur Uzun Ali Dirik Gülşen Bican

https://doi.org/10.5799/ahinjs.01.2013.01.0228

Abstract

Objectives: The purpose of this randomized study is to compare the effects of esmolol and lidocaine in the con­trol of hemodynamic response caused by endotracheal intubation. Methods: In this study, 40 patients with ASA I-II physical status and between the ages of 19 and 76 were included and randomly divided into two groups. In the Group E (n = 20), iv bolus injection of 1.5 mg/kg esmolol, in the Group L (n = 20), iv bolus injection of 1.5 mg/kg 2% lidocaine were given with iv bolus injection in 30 seconds. All pa­tients received the same anesthetic technique. Systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean blood pressure (MBP) and heart rate measure­ments were done at specified times and recorded. Re­cords were assessed by an anesthesiologist blinded to which drug is applied. Results: There was no difference between the groups in demographic data (p>0.05). In both groups, with the implementation of the study drug, systolic blood pressure, diastolic blood pressure and mean arterial blood pressure decreased compared to controls, this reduction was lower in Group E than Group L. In Group L, SBP values of 1.5 and 7 minutes were higher than Group E (p

Keywords

Esmolol, lidocaine, intubation, hemodynamic response

Entübasyona bağlı hemodinamik yanıtın kontrolünde esmolol ve lidokainin etkinliğinin karşılaştırılması: Randomize kontrollü çalışma

Abstract

Amaç: Bu randomize çalışmanın amacı endotrakeal en­tübasyonun neden olduğu hemodinamik yanıtın kontolün­de esmolol ve lidokainin etkilerini karşılaştırmayı amaçla­maktır. Yöntemler: Bu çalışmaya ASA I-II olan 19 ve 76 yaşları arasında 40 hasta dâhil edildi. Rastgele olarak iki grubuna ayrıldı. Grup E\' ye (n=20) 1,5 mg/kg esmolol, Grup L\'ye (n=20) 1.5 mg/kg %2 lidokain i.v bolus olarak 30 saniye­de anestezist tarafından uygulandı. Tüm hastalara aynı anestezi tekniği uygulandı. Sistolik kan basıncı (SKB), diastolik kan basıncı (DKB) ve ortalama kan basınçları (OKB) ile kalp atım hızı için belirlenen zamanlarda ölçüm­ler yapılarak kaydedildi. Bu ölçümler ve daha sonra yapı­lan değerlendirmeler, hangi ilacın uygulandığını bilmeyen bir anestezist tarafından gerçekleştirildi. Bulgular: Gruplar arasında demografik veriler açısından fark bulunmadı (p>0.05). Her iki grupta da çalışma ilacı­nın uygulanmasıyla kalp atım hızı, sistolik kan basıncı, diyastolik kan basıncı ve ortalama kan basıncı düzeyle­rininin kontrol değerlerine göre azaldığını, bu azalmanın Grup E\' de daha belirgin olduğunu ve Grup L\' ye göre düşük bulundu. Grup L\' nin 1,5 ve 7. dakika SKB değerleri Grup E\' ye göre daha yüksek bulundu (p

Keywords

Esmolol; lidokain; entübasyon; he­modinamik yanıt

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