Transient normoprolactinemic galactorrhea induced by fluoxetine

Year 2013, Volume: 4 Issue: 1, - , 01.03.2013

Fatih Canan Unsal Aydinoglu Gjergji Sinani

https://doi.org/10.5799/ahinjs.01.2013.01.0243

Cited By: 1

Abstract

Hormonal side effects of antidepressants are infrequent. Galactorrhea is rarely reported among antidepressant related side effects. Antidepressants can directly stimu­late postsynaptic 5- Hydroxytryptamine (5-HT) receptors in the hypothalamus or indirectly inhibit the tuberoinfun­dibular dopaminergic neurons through 5-HT, which may increase prolactin levels and later cause galactorrhea. However, galactorrhea may develop despite normal pro­lactin levels during antidepressant treatment. We present a case of normoprolactinemic galactorrhea in a woman, related with fluoxetine treatment. This report highlights the presence of unidentified mechanisms of selective serotonin reuptake inhibitor induced galactorrhea. J Clin Exp Invest 2013; 4 (1): 105-106

Keywords

Fluoxetine, galactorrhea, side effect

Fluoksetine bağlı, geçici normoprolaktinemik galaktore

Abstract

Antidepresanlara bağlı hormonal yan etkiler sık görülme­mektedir. Galaktore, antidepresanlara bağlı yan etkiler arasında nadiren bildirilmiştir. Antidepresanlar, hipotala­mustaki postsinaptik 5-Hidroksitriptamin (5-HT) reseptör­lerini doğrudan uyararak veya tuberoinfindibuler dopami­nerjik nöronları 5-HT üzerinden dolaylı olarak inhibe ede­rek prolaktin seviyelerinde artışa ve sonuçta galaktoreye neden olabilirler. Ancak antidepresan tedavisi sırasında normal prolaktin seviyelerine rağmen galaktore gelişebilir. Bu çalışmada fluoksetin tedavisi ile ilişkili normoprolakti­nemik galaktore gelişen bir kadın olgu sunulacaktır. Bu olgu sunumu ile selektif serotonin gerialım inhibitörlerine bağlı galaktorenin tanımlanmamış mekanizmalarının var­lığı üzerine vurgu yapılacaktır.

Keywords

Fluoksetin, galaktore, yan etki

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