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Assessment of dehydroepiandrosterone sulphate and total serum testosterone in Iraqi women with post-adolescent acne

Year 2015, Volume: 6 Issue: 2, 121 - 125, 10.07.2015
https://doi.org/10.5799/ahinjs.01.2015.02.0501

Abstract

Objectives: The aim of this study was to assess dehydroepiandrosterone sulphate (DHEA-S) and total serum testosterone (TST) in women with post-adolescent acne and their relationship to severity of acne and clinical markers of androgenicity.

Methods: Two hundred forty women with post-adolescent acne (PAA), 132 women with late- onset acne (LOA) and 108 women with persistent acne (PA) were recruited in this cross-sectional study. All patients were examined clinically and by ultrasound for evidence of polycystic ovaries (PCO), and serum DHEA-S and TST levels were measured.

Results: The results showed that there was an excess in androgens (DHEA-S) and TST levels. Serum androgens level were significantly correlated to the severity of PAA. In addition, clinical markers of androgenicity were frequently observed in women with PAA.

Conclusion: There is an increased level of circulating androgens in significant proportion of women with PAA and it seems that hyperandrogenism appears to play an important role in the etiopathogenesis of acne. In addition, there was a direct correlation between severity of acne and androgen levels suggesting that both ovarian and adrenal abnormalities are common at this patients group. J Clin Exp Invest 2015; 6 (2): 121-125

Key words: Dehydroepiandrosterone sulphate, total serum testosterone, post-adolescent acne

References

  • Layton AM. Disorder of the Sebaceous Glands. In: Burns T, Breathnach S, Cox N, Griffiths C. eds. Rook’s Textbook of Dermatology, 8th edn. London. Blackwell Publishing Company, 2010;42:1-89.
  • James WD, Berger TG, and Elston DM. Acne. In: Andrews Disease of the Skin, Clinical Dermatology, 10th edn. Philadelphia .WB Sounder Company ,2006;13:231-242.
  • Williams C, Layton AM. Persistent acne in women: implications for patient & for therapy. Am J Clin Dermatol 2006;7:281-290.
  • Breneau S, Dreno B. Female acne: a different subtype of teenager acne. J Eur Acad Dermatol Venereol. 2012; 26:277-282.
  • Zuazaga GJ. Pseudofolliculitis barbae; Review and update on new treatment modalities. Mil Med 2003;168:561-564.
  • Poli F, Dereno B, Verschore M. An epidemiological study of acne in female adult: result of survey conducted in France. J Eur Acad Dermatol Venereol 2001;15:541-545.
  • Knaggs HE, Wood EJ, Rizer RL, Mills OH. Post-adolescent acne. Int J Cosm Sci 2004; 26: 129-38.
  • James, William D. Acne. New Engl J Med 2005;352:1463-1472.
  • Elmlinger MW, Kuhnel W, Ranke MB: Reference ranges for serum concentrations of lutropin, follitropin, estradiol, prolactin, progesterone, sex hormone binding globulin, dehydroepiandrosterone sulfate, cortisol, ferritin in neonates, children & young adults. Clin Chem Lab Med 2002;40:1151-1160.
  • Seirafi H, Farnaghi F, Vasheghani-Farahani A, et al. Assessment of androgens in women with adult-onset acne. Inter J Dermatol 2007;46:1188-1191.
  • Darley CR, Kirby JD, Besser GM, et al. Circulating testosterone, sex hormone binding globulin and prolactin in women with late onset or persistent acne vulgaris. Br J Dermatol 1982;106:517-522.
  • Maneschi F, Pandolfo MC,et al. Androgenic evaluation of women with late-onset or persistent acne. Minerva Ginecol 1989;41:99-103.
  • Vexiau P, Husson C, Chivot M, et al. Androgen excess in women with acne alone compared with women with acne and/or hirsuitism. J Invest Dermatol 1990;94:179-283.
  • Slayden SM, Moran C, Sams WM, et al. Hyperandrogenism in patients presenting with acne. Fertil Steril 2001;75:889-892.
  • Darley CR, Moore JW, Besser GM, et al. Androgen status in women with late onset or persistent acne vulgaris. Clin Exp Dermatol. 1984;9:28-35.
  • Goulden V, Clark SM, Cunliffe WJ. Post-adolescent acne; a review of clinical features. Br. J. Dermatol 1997;136:66-70.
  • Walton S, Cunliffe WJ, Keczkes K, et al. Clinical, ultrasound and abnormal markers of androgenicity in acne vulgaris. Br J Dermatol 1995;133:249-253.
  • Cibula D, Hill M, Kuzel D, et al. The role of androgens in determining acne severity in adult women. Br J Dermatol 2000;143:399-404.
  • O ́Loughlin, M. Acne in the adult female. Aust J Dermatol 1964;7:218-222.
  • Timpatanapong P, Rojanasakul A. Hormonal profiles and prevalence of polycystic ovary syndrome in women with acne. J Dermatol 1997;24:223-229.
  • Aizawa H, Niimura M. Adrenal androgen abnormalities in women with late onset and persistent acne. Arch Dermatol Res 1993;284:451-455.
  • Homburg R, Lambalk CB. Polycystic ovary syndrome in adolescence- a therapeutic conundrum. Hum Reprod 2004;19:1039-1042.
  • Punker CB, Newton JA, Kilborn J, et al. Most women with acne have polycystic ovaries. Br J Dermatol 1989;121:675-680.
  • Paulina AE, Edmond PW, Julia RN, et al. Dermatology of androgen-related disorders. Clin Dermatol 2006;24:289-298.
  • Carmina E, Koyama T, Chang L, et al. Does ethnicity influence the prevalence of adrenal hyperandrogenism and insulin resistance in polycystic ovary syndrome? Am J Obstet Gynecol 1992;167:1807–1812.
  • Wild RA, Umstot ED, Andersen RN, et al. Androgen parameters and their correlation with body weight in one hundred thirty-eight women thought to have hyperandrogenism. Am J Obstet Gynecol 1983;146:602–605.
  • Hoffman DI, Klove K, Lobo RA. The prevalence and significance of elevated dehydroepiandrosterone sulfate levels in anovulatory women. Fertil Steril 1984;42:76–81.
  • Filicori M. Abnormalities of gonadotropin secretion in PCOS. In: Azziz R, Nestler JE, Dewailly D, eds. Androgen excess disorders in women. Philadelphia: Lippincott-Raven.1997;279–286.
  • Azziz R, Boots LR, Parker Jr CR, et el. 11βHydroxylase deficiency in hyperandrogenism. Fertil Steril 1991;55:733–741.

Correspondence: Samer A. Dhaher

Year 2015, Volume: 6 Issue: 2, 121 - 125, 10.07.2015
https://doi.org/10.5799/ahinjs.01.2015.02.0501

Abstract

Amaç: Bu çalışmanın amacı adolesan sonrası akne’li kadınlarda dehidroepiandrosteron sulfat (DHEA-S) ve total serum testosteronun (TST) ve bunların akne şiddeti ve androjenikliğin klinik belirteçleri ile ilişkisini değerlendirmektir. Yöntemler: Adolesan sonrası akne’li 240 kadın, 132 tanesi geç başlangıçlı akne ve 108 tanesi sürekli akneli kadın kesitsel çalışmaya alındı. Hastaların tümü klinik olarak ve polikistik over yönünden ultrasonografi ile değerlendirildi ve serum DHEA-S ve TST düzeyleri ölçüldü.Bulgular: Veriler DHEA-S ve TST düzeylerinde fazlalık olduğunu gösterdi. Serum androjen düzeyi akne şiddeti ile anlamlı korelasyon gösterdi. Ayrıca adolesan sonrası akne’li kadınlarda androjenikliğin klinik belirtileri sıklıkla gözlendi.Sonuç: Adolesan sonrası önemli sayıdaki akne’li kadında artmış dolaşan androjen düzeyleri ve öyle görünüyor ki bu akne etyopatogenezinde önemli bir rol oynuyor. Ayrıca akne şiddeti ile androjen düzeyleri arasında doğrudan bir ilişki olması, bu hasta grubunda hem over hem de adrenal anormalliklerin yaygın olduğunu telkin etmektedir

References

  • Layton AM. Disorder of the Sebaceous Glands. In: Burns T, Breathnach S, Cox N, Griffiths C. eds. Rook’s Textbook of Dermatology, 8th edn. London. Blackwell Publishing Company, 2010;42:1-89.
  • James WD, Berger TG, and Elston DM. Acne. In: Andrews Disease of the Skin, Clinical Dermatology, 10th edn. Philadelphia .WB Sounder Company ,2006;13:231-242.
  • Williams C, Layton AM. Persistent acne in women: implications for patient & for therapy. Am J Clin Dermatol 2006;7:281-290.
  • Breneau S, Dreno B. Female acne: a different subtype of teenager acne. J Eur Acad Dermatol Venereol. 2012; 26:277-282.
  • Zuazaga GJ. Pseudofolliculitis barbae; Review and update on new treatment modalities. Mil Med 2003;168:561-564.
  • Poli F, Dereno B, Verschore M. An epidemiological study of acne in female adult: result of survey conducted in France. J Eur Acad Dermatol Venereol 2001;15:541-545.
  • Knaggs HE, Wood EJ, Rizer RL, Mills OH. Post-adolescent acne. Int J Cosm Sci 2004; 26: 129-38.
  • James, William D. Acne. New Engl J Med 2005;352:1463-1472.
  • Elmlinger MW, Kuhnel W, Ranke MB: Reference ranges for serum concentrations of lutropin, follitropin, estradiol, prolactin, progesterone, sex hormone binding globulin, dehydroepiandrosterone sulfate, cortisol, ferritin in neonates, children & young adults. Clin Chem Lab Med 2002;40:1151-1160.
  • Seirafi H, Farnaghi F, Vasheghani-Farahani A, et al. Assessment of androgens in women with adult-onset acne. Inter J Dermatol 2007;46:1188-1191.
  • Darley CR, Kirby JD, Besser GM, et al. Circulating testosterone, sex hormone binding globulin and prolactin in women with late onset or persistent acne vulgaris. Br J Dermatol 1982;106:517-522.
  • Maneschi F, Pandolfo MC,et al. Androgenic evaluation of women with late-onset or persistent acne. Minerva Ginecol 1989;41:99-103.
  • Vexiau P, Husson C, Chivot M, et al. Androgen excess in women with acne alone compared with women with acne and/or hirsuitism. J Invest Dermatol 1990;94:179-283.
  • Slayden SM, Moran C, Sams WM, et al. Hyperandrogenism in patients presenting with acne. Fertil Steril 2001;75:889-892.
  • Darley CR, Moore JW, Besser GM, et al. Androgen status in women with late onset or persistent acne vulgaris. Clin Exp Dermatol. 1984;9:28-35.
  • Goulden V, Clark SM, Cunliffe WJ. Post-adolescent acne; a review of clinical features. Br. J. Dermatol 1997;136:66-70.
  • Walton S, Cunliffe WJ, Keczkes K, et al. Clinical, ultrasound and abnormal markers of androgenicity in acne vulgaris. Br J Dermatol 1995;133:249-253.
  • Cibula D, Hill M, Kuzel D, et al. The role of androgens in determining acne severity in adult women. Br J Dermatol 2000;143:399-404.
  • O ́Loughlin, M. Acne in the adult female. Aust J Dermatol 1964;7:218-222.
  • Timpatanapong P, Rojanasakul A. Hormonal profiles and prevalence of polycystic ovary syndrome in women with acne. J Dermatol 1997;24:223-229.
  • Aizawa H, Niimura M. Adrenal androgen abnormalities in women with late onset and persistent acne. Arch Dermatol Res 1993;284:451-455.
  • Homburg R, Lambalk CB. Polycystic ovary syndrome in adolescence- a therapeutic conundrum. Hum Reprod 2004;19:1039-1042.
  • Punker CB, Newton JA, Kilborn J, et al. Most women with acne have polycystic ovaries. Br J Dermatol 1989;121:675-680.
  • Paulina AE, Edmond PW, Julia RN, et al. Dermatology of androgen-related disorders. Clin Dermatol 2006;24:289-298.
  • Carmina E, Koyama T, Chang L, et al. Does ethnicity influence the prevalence of adrenal hyperandrogenism and insulin resistance in polycystic ovary syndrome? Am J Obstet Gynecol 1992;167:1807–1812.
  • Wild RA, Umstot ED, Andersen RN, et al. Androgen parameters and their correlation with body weight in one hundred thirty-eight women thought to have hyperandrogenism. Am J Obstet Gynecol 1983;146:602–605.
  • Hoffman DI, Klove K, Lobo RA. The prevalence and significance of elevated dehydroepiandrosterone sulfate levels in anovulatory women. Fertil Steril 1984;42:76–81.
  • Filicori M. Abnormalities of gonadotropin secretion in PCOS. In: Azziz R, Nestler JE, Dewailly D, eds. Androgen excess disorders in women. Philadelphia: Lippincott-Raven.1997;279–286.
  • Azziz R, Boots LR, Parker Jr CR, et el. 11βHydroxylase deficiency in hyperandrogenism. Fertil Steril 1991;55:733–741.
There are 29 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Samer A. Dhaher This is me

Khalil I. Al-hamdi This is me

Jinan Q. Mohammed This is me

Publication Date July 10, 2015
Published in Issue Year 2015 Volume: 6 Issue: 2

Cite

APA Dhaher, S. A., Al-hamdi, K. I., & Mohammed, J. Q. (2015). Assessment of dehydroepiandrosterone sulphate and total serum testosterone in Iraqi women with post-adolescent acne. Journal of Clinical and Experimental Investigations, 6(2), 121-125. https://doi.org/10.5799/ahinjs.01.2015.02.0501
AMA Dhaher SA, Al-hamdi KI, Mohammed JQ. Assessment of dehydroepiandrosterone sulphate and total serum testosterone in Iraqi women with post-adolescent acne. J Clin Exp Invest. July 2015;6(2):121-125. doi:10.5799/ahinjs.01.2015.02.0501
Chicago Dhaher, Samer A., Khalil I. Al-hamdi, and Jinan Q. Mohammed. “Assessment of Dehydroepiandrosterone Sulphate and Total Serum Testosterone in Iraqi Women With Post-Adolescent Acne”. Journal of Clinical and Experimental Investigations 6, no. 2 (July 2015): 121-25. https://doi.org/10.5799/ahinjs.01.2015.02.0501.
EndNote Dhaher SA, Al-hamdi KI, Mohammed JQ (July 1, 2015) Assessment of dehydroepiandrosterone sulphate and total serum testosterone in Iraqi women with post-adolescent acne. Journal of Clinical and Experimental Investigations 6 2 121–125.
IEEE S. A. Dhaher, K. I. Al-hamdi, and J. Q. Mohammed, “Assessment of dehydroepiandrosterone sulphate and total serum testosterone in Iraqi women with post-adolescent acne”, J Clin Exp Invest, vol. 6, no. 2, pp. 121–125, 2015, doi: 10.5799/ahinjs.01.2015.02.0501.
ISNAD Dhaher, Samer A. et al. “Assessment of Dehydroepiandrosterone Sulphate and Total Serum Testosterone in Iraqi Women With Post-Adolescent Acne”. Journal of Clinical and Experimental Investigations 6/2 (July 2015), 121-125. https://doi.org/10.5799/ahinjs.01.2015.02.0501.
JAMA Dhaher SA, Al-hamdi KI, Mohammed JQ. Assessment of dehydroepiandrosterone sulphate and total serum testosterone in Iraqi women with post-adolescent acne. J Clin Exp Invest. 2015;6:121–125.
MLA Dhaher, Samer A. et al. “Assessment of Dehydroepiandrosterone Sulphate and Total Serum Testosterone in Iraqi Women With Post-Adolescent Acne”. Journal of Clinical and Experimental Investigations, vol. 6, no. 2, 2015, pp. 121-5, doi:10.5799/ahinjs.01.2015.02.0501.
Vancouver Dhaher SA, Al-hamdi KI, Mohammed JQ. Assessment of dehydroepiandrosterone sulphate and total serum testosterone in Iraqi women with post-adolescent acne. J Clin Exp Invest. 2015;6(2):121-5.