Abstract
Paliperidone is an atypical antipsychotic drug used to treat schizophrenia. Paliperidone can cause some rare side effects during treatment. Despite many publications of mania and hypomania induced by antipsychotics, mania cases induced by paliperidone are few in the literature. In this case a schizophrenia patient showing symptoms of mania during usage of paliperidone with a dose of 9 mg/day in which the symptoms rapidly disappeared after discontinuation of paliperidone and initiation of aripiprazole was reported. Clinicians should be aware of that Paliperidone treatment may trigger mania symptoms. J Clin Exp Invest 2015; 6 (3): 321-323
Keywords
References
- Dilbaz N, Darçın AE. Antipsikotik İlaçlarla Tedavide Yeni Bir Teknoloji; Paliperidon. Bull Clin Psychopharmacol 2009;19:316-325.
- Davidson M, Emsley R, Kramer M, et al. Efficacy, safety and early response of paliperidone extendedrelease tablets (paliperidone ER): results of a 6-week, randomized, placebo-controlled study. Schizophr Res 2007;93:117-130.
- Wang WT, Chen CH, Lu M-L, Lai T-J. Paliperidoneinduced mania-like symptoms: A case report. Progress Neuro-Psychopharmacol Biol Psychiatry 2010;34:1351-1352.
- Hsieh CH, Liou YJ. Manic symptoms induced by paliperidone.
- J Clin Psychopharmacol 2010;30:202-204.
- Yang FW, Liang CS. Manic symptoms during a switch from risperidone to paliperidone: a case report. J Neuropsychiatry Clin Neurosci 2011;23:29.
- Benyamina A, Samalin L. Atypical antipsychotic induced mania/hypomania: a review of recent case reports and linicalstudies. Int J Psychiatry Clin Pract 2012;16:2-7.
- Celada P, Puig MV, Amarg ós -Bosch M, et al. The therapeutic role of 5-HT1A and 5-HT2A receptors in depression. J Psychiatry Neurosci 2004;29:252-265.
- Michalopoulou PG, Lykouras L. Manic/hypomanic symptoms nduced by atypical antipsychotics: A review of the reported cases. Progress Neuro-Psychopharmacol Biol Psychiatry 2006;30:549-564.
- Kramer M, Simpson G, Maciulis V, et al. Paliperidone extended-release tablets for prevention of symptom recurrence in patients with schizophrenia: a randomized, double-blind, placebo-controlled study. J Clin Psychopharmacol 2007;27:6-14.
- Stahl SM. Paliperidone. In: Stahl’s Essential sychopharmacology:
- Neuroscientific Basis and Practical Applications. 3rd ed. New York, NY: Cambridge University Press; 2008:413-414.
Abstract
Paliperidon şizofreni tedavisi için kullanılan atipik antipsikotik bir ilaçtır. Paliperidon tedavisi sırasında bazı nadir yan etkiler görülebilmektedir. Literatürde antipsikotiklerin indüklediği hipomanik ve manik belirtiler ile ilgili çok sayıda olgu sunumu olmasına rağmen paliperidonun indüklediği mani olguları kısıtlı sayıda yayınlanmıştır. Bu olguda 9 mg/gün paliperidon tedavisi başlandıktan sonra mani belirtileri görülen, paliperidon kesilip aripiprazol başlanması ile mani belirtilerinin hızla düzeldiği bir şizofreni hastası sunulmaktadır. Klinisyenler şizofreni hastalarında, paliperidon tedavisinin mani belirtilerini tetikleyebileceğini göz önünde tutmalıdır.
Anahtar kelimeler: Paliperidon, şizofreni, mani
Keywords
References
- Dilbaz N, Darçın AE. Antipsikotik İlaçlarla Tedavide Yeni Bir Teknoloji; Paliperidon. Bull Clin Psychopharmacol 2009;19:316-325.
- Davidson M, Emsley R, Kramer M, et al. Efficacy, safety and early response of paliperidone extendedrelease tablets (paliperidone ER): results of a 6-week, randomized, placebo-controlled study. Schizophr Res 2007;93:117-130.
- Wang WT, Chen CH, Lu M-L, Lai T-J. Paliperidoneinduced mania-like symptoms: A case report. Progress Neuro-Psychopharmacol Biol Psychiatry 2010;34:1351-1352.
- Hsieh CH, Liou YJ. Manic symptoms induced by paliperidone.
- J Clin Psychopharmacol 2010;30:202-204.
- Yang FW, Liang CS. Manic symptoms during a switch from risperidone to paliperidone: a case report. J Neuropsychiatry Clin Neurosci 2011;23:29.
- Benyamina A, Samalin L. Atypical antipsychotic induced mania/hypomania: a review of recent case reports and linicalstudies. Int J Psychiatry Clin Pract 2012;16:2-7.
- Celada P, Puig MV, Amarg ós -Bosch M, et al. The therapeutic role of 5-HT1A and 5-HT2A receptors in depression. J Psychiatry Neurosci 2004;29:252-265.
- Michalopoulou PG, Lykouras L. Manic/hypomanic symptoms nduced by atypical antipsychotics: A review of the reported cases. Progress Neuro-Psychopharmacol Biol Psychiatry 2006;30:549-564.
- Kramer M, Simpson G, Maciulis V, et al. Paliperidone extended-release tablets for prevention of symptom recurrence in patients with schizophrenia: a randomized, double-blind, placebo-controlled study. J Clin Psychopharmacol 2007;27:6-14.
- Stahl SM. Paliperidone. In: Stahl’s Essential sychopharmacology:
- Neuroscientific Basis and Practical Applications. 3rd ed. New York, NY: Cambridge University Press; 2008:413-414.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | October 25, 2015 |
| Published in Issue | Year 2015 Volume: 6 Issue: 3 |