<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.4 20241031//EN"
        "https://jats.nlm.nih.gov/publishing/1.4/JATS-journalpublishing1-4.dtd">
<article         dtd-version="1.4">
            <front>

                <journal-meta>
                                    <journal-id></journal-id>
            <journal-title-group>
                                                                                    <journal-title>Çocuk Dergisi</journal-title>
            </journal-title-group>
                                        <issn pub-type="epub">1308-8491</issn>
                                                                                            <publisher>
                    <publisher-name>Istanbul University</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id pub-id-type="doi">10.5222/j.child.2017.001</article-id>
                                                                                                                                                                                            <title-group>
                                                                                                                        <article-title>Cistus Incanus Bitki Özünün Anti-Enfektif Özellikleri</article-title>
                                                                                                                                                                                                <trans-title-group xml:lang="en">
                                    <trans-title>Anti-infective Properties of Cistus Incanus, a Plant Extract</trans-title>
                                </trans-title-group>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                <name>
                                    <surname>Somer</surname>
                                    <given-names>Ayper</given-names>
                                </name>
                                                                    <aff>İstanbul Üniversitesi İstanbul Tıp Fakültesi, Çocuk Enfeksiyon  ve Klinik İmmünoloji Bilim Dalı</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                <name>
                                    <surname>Sütçü</surname>
                                    <given-names>Murat</given-names>
                                </name>
                                                                    <aff>İstanbul Üniversitesi İstanbul Tıp Fakültesi, Çocuk Enfeksiyon  ve Klinik İmmünoloji Bilim Dalı</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20170101">
                    <day>01</day>
                    <month>01</month>
                    <year>2017</year>
                </pub-date>
                                        <volume>17</volume>
                                        <issue>1</issue>
                                        <fpage>1</fpage>
                                        <lpage>3</lpage>
                        
                        <history>
                                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 2000, Journal of Child</copyright-statement>
                    <copyright-year>2000</copyright-year>
                    <copyright-holder>Journal of Child</copyright-holder>
                </permissions>
            
                                                                                                <abstract><p>Dünyada en yaygın hastalık olan üst solunum yolu enfeksi- yonları  ÜSYE  yüksek morbidite, mortalite ve ekonomik  kayıplara yol açmaktadır. ÜSYE etiyolojisinde en sık sapta- nan patojenler viruslardır. Korunma ve tedavi amaçlı bir- çok antiviral özellikte madde geliştirilmiştir. Cystus052,  Cistus incanus bitkisinden elde edilen bir bitki özütü olup,  polimerik polifenollerden zengindir ve antiviral etkinliği  gösterilmiştir. Bu makalede Cistus incanus bitki özütünün  özellikleri ve etkinliği değerlendirilmektedir</p></abstract>
                                                                                                                                    <trans-abstract xml:lang="en">
                            <p>The most common diseases in the world are upper respira- tory tract infections, resulting in substantial morbidity,  mortality, and financial loss. Viruses are reported to be the  most important pathogens involved in URT etiology.  Several antiviral compounds have been developed for tre- atment, and prophylaxis. Cystus052, a an extract from a  special variety of Cistus incanus plant that is rich in poly- meric polyphenols, has been shown to exhibit antiviral  activity. In this article, the properties and efficacy of Cistus  incanus are reviewed</p></trans-abstract>
                                                            
            
                                                            <kwd-group>
                                                    <kwd>Cistus</kwd>
                                                    <kwd>  polifenoller</kwd>
                                                    <kwd>  üst solunum yolu enfeksiyonları</kwd>
                                                    <kwd>  antiviral ajanlar</kwd>
                                            </kwd-group>
                                                        
                                                                            <kwd-group xml:lang="en">
                                                    <kwd>Cistus</kwd>
                                                    <kwd>  polyphenols</kwd>
                                                    <kwd>  upper respiratory infections</kwd>
                                                    <kwd>  antiviral agents</kwd>
                                            </kwd-group>
                                                                                                            </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">Cos P, De Bruyne T, Hermans N, Apers S, Vanden Berghe D, Vlietinck AJ. Proanthocyanidins in health care: current and new trends. Curr Med Chem 2004;11:1345-59. http://dx.doi.org/10.2174/0929867043365288</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">Nakayama M, Suzuki K, Toda M, Okubo S, Hara Y, Shimamura T. Inhibition of the infectivity of influenza virus by tea polyphenols. Antiviral Res 1993;21:289-99. http://dx.doi.org/10.1016/0166-3542(93)90008-7</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">Urquiaga I, Leighton F. Plant polyphenol antioxidants and oxidative stress. Biol Res 2000;33:55-64. http://dx.doi.org/10.4067/S0716-97602000000200004</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">Ehrhardt C, Hrincius, ER, Korte V, Mazur I, Droebner K, et al. A polyphenol rich plant extract, CYSTUS052, exerts anti influenza virus activity in cell culture without toxic side effects or the tendency to induce viral resistance. Antiviral Res 2007;76:38-47. http://dx.doi.org/10.1016/j.antiviral.2007.05.002</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">Kalusa U, Grigorova A, Kadeckib O, Jansenc JP, Kiesewettera H, Radtkea H. Cistus incanus (CYSTUS052) for treating patients with infection of the upper respiratory tract A prospective, randomised, placebo-controlled clinical study. Antiviral Research 2009;84:267-71. http://dx.doi.org/10.1016/j.antiviral.2009.10.001</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">Kalus U, Kiesewetter H, Radtke H. Effect of CYSTUS052 and green tea on subjective symptoms in patients with infection of the upper respiratory tract. Phytother Res 2010;24:96-100. http://dx.doi.org/10.1002/ptr.2876</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">Kiesewetter H. Cystussud zur lokalen Behandlung der Tonsillopharyngitis. Erfahrungsheilkunge 2002;11:792- 93.</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">Rebensburg S, Helfer M, Schneider M, Herwig Koppensteiner H, Eberle J, et al. Potent in vitro anti- viral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins. Scientific Reports 2016;6:20394. http://dx.doi.org/10.1038/srep20394</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">Wittpahl G, Kölling-Speer I, Basche S, Herrmann E, Hannig M, Speer K, et al. The polyphenolic com- position of Cistus incanus herbal tea and its antibacte- rial and anti-adherent activity against Streptococcus mutans. Planta Med 2015;81:1727-35. http://dx.doi.org/10.1055/s-0035-1557822</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">Kalliomaki M, Antoine JM, Herz U, Rijkers GT, Wells JM, Mercenier A. Guidance for substantiating the evidence for beneficial effects of probiotics: pre- vention and management of allergic diseases by probi- otics. J Nutr 2010;140:713-21. http://dx.doi.org/10.3945/jn.109.113761</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">Singh A, Holvoet S, Mercenier A. Dietary polyphenols in the prevention and treatment of allergic diseases. Clinical &amp; Experimental Allergy 2011;41:1346-59. http://dx.doi.org/10.1111/j.1365-2222.2011.03773.x</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
