Abstract
Aim: The aim of this study was to evaluate the etiological factors in a large group of children with central diabetes insipitus CDI , to assess the significance of anthropometric parameters at presentation with respect to different etiologies, and the follow up data after the spesific treatment. Method: The records of 48 patients 20F, 28M with CID were reviewed retrospectively. Height and weight at presentation and at last visit were expressed as standart deviation score SDS . The cerebral magnetic resonance imaging MRI findings of patients were reevaluated. Results: The etiology of CDI in 20 cases 41.7 % was considered to be idiopathic, 8 16.7 % cases were histiyocytosis; 7 14.7 % cases were craniofaringioma; 4 8.4 % cases were due to head trauma; 4 8.4 % cases were empty sella; 1 2 % case was DİDMOAD syndrome diabetes insipitus, diabetes mellitus, optic atropy, deafness . Height and weigth SDS of the patients at presentation were -1.0 ±0.9 and -0.9± 1.2 respectively. When evaluated according to the etiology, height SDS values at presentation were significantly lower in multiple hormon deficiency group [-1.2 ±1.9 ] with respect to isolated AVP arginin vasopressin peptid deficiency [0.4 ±2.1 ] p
Keywords
References
- Bode HH, et al. Disorders of antidiuretic hormon homeosta- sis. Pediatric endocrinology. Marcel Dekker, New York, 1996; 731-43.
- nity: Relationship between the occurence of antibodies to arginine vasopressin-secreting cells and clinical, immunolo- gical and radiological features in a large cohort of patients with central diabetes insipidus of known and unknown etio- logy. J Clin Endocrinology & Metabolism 2003; 88:1629-36. sible autoimmune type with vasopressin cell antibodies. J Pediatr 1985; 107:922-5
- Nobel Üçüncü Baskı. İstanbul: Nobel, 2002: 79-99.
- tes İnsipidus with linka ge to chromosome 20p13 but without mutations in the AVP-NPII Gene. J Clin Endocrinology & Metabolism 90:4388-93.
- disease. In Blizzard RM. Editor. Growth, Genetic and Hormones. California: Gardier-Caldwell: Syner Med, 1995: 11:1-5.
- Ikema T, Takasu N. Serial T1- weighted magnetic resonance imaging changes in a patient with central daibetes insipidus, possibly due to lymphocytic infundibuloneurohypophysitis. Euro J Endocrin 2005; 153:989-90.
- with diabetes insipidus. Bol Med Hosp Infant Mex 1998; 37:1103-11.
- diabetes insipidus: diagnosis, clinical, endocrine and follow- up, Horn Res 1998; 50:15.
- of central diabetes insipidus in 21 children. Turk J Med Sci 1997; 27:315-7.
- betes insipidusun etiyolojik değerlendirilmesi. Klinik Girişim (803-807) 1999 .
Abstract
Amaç: Çocukluk döneminde santral diyabetes insipitus SDI tanısıyla izlenen geniş bir vaka grubunun etiyolojik değerlendirmesini yapmak, hastaların başvurudaki antropometrik verilerinin etiyolojik tanı açısından önemini irdelemek ve tedavi sonrası durumlarını değerlendirmek amacı ile SDI tanısı alan 48 hastanın bulguları geriye dönük değerlendirildi. Yöntem: Poliüri ve polidipsi yakınmaları ile polikliniğimize başvuran ve SDI tanısı alan 48 20 kız, 28 erkek vaka geriye dönük olarak dosyalarından değerlendirildi. Başvuru ve izlemdeki boy ve kilo değerleri standart deviasyon skoru SDS olarak dile getirildi. İdiyopatik vakalar beş yıl boyunca yılda bir çekilen hipofiz manyetik rezonans görüntüleme MRI ile değerlendirildi. Bulgular: Vakaların 20’si % 41.7 idiyopatik olarak değerlendirilirken; sırasıyla 8 % 16.7 vakada histiyositoz, 7 % 14.7 vakada kraniofarengioma, 4 % 8.4 vakada kafa travması, 4 % 8.4 vakada boş sella, 1 % 2 vakada DİDMOAD diyabetes insipitus, diyabetes mellitus, optik atrofi, sağırlık saptandı. Vakaların ortalama geliş boy SDS değeri -1.0 ±0.9 ; ağırlık SDS’si -0.9± 1.2 SDS idi. Vakalar izole AVP arginin vazopressin peptid eksikliği n:23 ve çoğul hormon eksikliği n:25 olarak iki gruba ayrıldığında ortalama başvuru boy SDS’si çoğul hormon yetersizliği olan grupta -1.2 ±1.9 ; izole hormon eksikliği olan grupta -0.4 ±2.1 olup, çoğul hormon eksikliği olan grupta anlamlı olarak düşük bulundu p
References
- Bode HH, et al. Disorders of antidiuretic hormon homeosta- sis. Pediatric endocrinology. Marcel Dekker, New York, 1996; 731-43.
- nity: Relationship between the occurence of antibodies to arginine vasopressin-secreting cells and clinical, immunolo- gical and radiological features in a large cohort of patients with central diabetes insipidus of known and unknown etio- logy. J Clin Endocrinology & Metabolism 2003; 88:1629-36. sible autoimmune type with vasopressin cell antibodies. J Pediatr 1985; 107:922-5
- Nobel Üçüncü Baskı. İstanbul: Nobel, 2002: 79-99.
- tes İnsipidus with linka ge to chromosome 20p13 but without mutations in the AVP-NPII Gene. J Clin Endocrinology & Metabolism 90:4388-93.
- disease. In Blizzard RM. Editor. Growth, Genetic and Hormones. California: Gardier-Caldwell: Syner Med, 1995: 11:1-5.
- Ikema T, Takasu N. Serial T1- weighted magnetic resonance imaging changes in a patient with central daibetes insipidus, possibly due to lymphocytic infundibuloneurohypophysitis. Euro J Endocrin 2005; 153:989-90.
- with diabetes insipidus. Bol Med Hosp Infant Mex 1998; 37:1103-11.
- diabetes insipidus: diagnosis, clinical, endocrine and follow- up, Horn Res 1998; 50:15.
- of central diabetes insipidus in 21 children. Turk J Med Sci 1997; 27:315-7.
- betes insipidusun etiyolojik değerlendirilmesi. Klinik Girişim (803-807) 1999 .
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Research Articles |
| Authors | |
| Publication Date | October 1, 2008 |
| Published in Issue | Year 2008 Volume: 8 Issue: 4 |