Investigation of the impact of COVID-19 in Children/ adolescents with Juvenile idiopathic Arthritis from a Holistic Perspective: A Controlled Trial
Abstract
Objective: The study aimed to examine the effect of coronavirus (COVID-19) exposure on the function and quality of life in children/adolescents with Juvenile Idiopathic Arthritis (JIA).
Materials and Methods: 45 children/adolescents diagnosed with JIA (29 female, 16 male) were included. The impact of coronavirus was questioned with the Numerical Analog Scale, disability level with the Childhood Health Assessment Questionnaire (CHAQ), and quality of life with the Pediatric Quality Of Life Inventory 3.0. Module Arthritis (PedsQL). Participants were divided into two groups: JIA with COVID-19 (n=21) and without COVID-19 (n=24).
Results: The mean age of children/adolescents with JIA’s mean age was 13.16 ± 3.53 and disease duration was 3.58 ±2.93 years. There was no difference in impact from coronavirus, quality of life, and disability level between JIA with COVID-19 (46.7%) and without COVID-19 (53.3%)(p>0.05). General health impact from coronavirus had moderate correlation with quality of life-child (r=-0.371) and high correlation with disability level (r=0.511). Psychosocial impact from coronavirus had moderate correlation with quality of life-child (r=-0.493) and quality of life-parent (r=-0,361) and high correlation with disability level (r=0.536). Activity impact from coronavirus had a moderate correlation with quality of life-child (r=-0.371) and a moderate correlation with disability level (r=0.444).
Conclusion: According to our data results, during the pandemic period, children/adolescents with JIA were affected by the coronavirus at the same level whether they had COVID-19 or not, and their quality of life and disability levels did not change. Coronavirus has affected general health and activity, reducing the quality of life and increasing the level of disability. Psychosocially, it reduced the quality of life of both the child/adolescent with JIA and the parents.
Ethical Statement
Ethical approval of the study was obtained from the Pamukkale University ethics committee at the meeting number of 21 dated 11.30.2021. All individuals were informed verbally and informed consent forms were signed. The patients with JIA was prospectively registered.
References
- WHO, Coronavirus Disease (COVID-19). World Health Organization, Access date: November 2023, Available from: https://www.who.int/health-topics/ coronavirus#tab=tab_1 google scholar
- Kayis AR, Satici B, Deniz ME, Satici SA, Griffiths MD. Fear of covid-19, loneliness, smartphone addiction, and mental well-being among the Turkish general population: A serial mediation model. Behaviour and Information Technology 2021. google scholar
- Kuy S, Tsai R, Bhatt J, Chu QD, Gandhi P, Gupta R et al. Focusing on Vulnerable Populations During COVID-19. Acad Med 2020;95(11): e2-e3. google scholar
- Bucak IH, Almis H, Tasar SO, Uygun H, Turgut M. Have the sleep habits of the children of health workers been more affected during the COVID-19 pandemic? Sleep Med 2021;83: 235-240. google scholar
- Schmidt SCE, Anedda B, Burchartz A, Eichsteller A, Kolb S, C et al. Physical activity and screen time of children and adolescents before and during the COVID-19 lockdown in Germany: a natural experiment. Sci Rep 2020;10(1):21780. google scholar
- Štveráková T, Jačisko J, Busch A, Šafářová M, Kolář P, Kobesová A. The impact of COVID-19 on the Physical Activity of Czech children. PLoS One 2021;16(7): e0254244. google scholar
- Bansal N, Pasricha C, Kumari P, Jangra S, Kaur R, Singh R. A comprehensive overview of juvenile idiopathic arthritis: From pathophysiology to management. Autoimmun Rev 2023;22(7): 103337. google scholar
- Kelvin AA, Halperin S. COVID-19 in children: the link in the transmission chain. Lancet Infect Dis 2020;20(6): 633-634. google scholar
- Munro APS, Faust SN. Addendum to Children are not COVID-19 super spreaders: time to go back to school. Arch Dis Child 2021;106(2): e9. google scholar
- Durcan G, Barut K, Haslak F, Doktur H, Yildiz M, Adrovic A et al. Psychosocial and clinical effects of the COVID-19 pandemic in patients with childhood rheumatic diseases and their parents. Rheumatol Int 2021;41(3): 575-583. google scholar
- Quéré B, Lemelle I, Lohse A, Pillet P, Molimard J, Richer O et al. Juvenile Idiopathic Arthritis and COVID-19 Pandemic: Good Compliance with Treatment and Reluctance to Return to School. Front Med (Lausanne) 2021;8: 743815. google scholar
- Miserocchi E, Giuffrè C, Modorati GM, Cimaz R. Management of Juvenile idiopathic arthritis-associated uveitis during COVID-19 pandemic in a pediatric referral center in Lombardy. Ocul Immunol Inflamm 2020;28(8): 1305-1307. google scholar
- Fink CW, and the ILAR Task Force for Classification Criteria. A proposal for developing classification criteria for the idiopathic arthritides of childhood. J Rheumatol 1995;22:1566–9 google scholar
- Smith BW, Zautra AJ. Effects of anxiety and depression on weekly pain in women with arthritis. Pain 2005;115(3):358-365 google scholar
- Ozdogan H, Ruperto N, Kasapçopur O, Bakkaloglu A, Arisoy N, Ozen S et al. The Turkish version of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ). Clin Exp Rheumatol 2001;19(4 Suppl 23): S158-62. google scholar
- Tarakci E, Baydogan SN, Kasapcopur O, Dirican A. Cross-cultural adaptation, reliability, and validity of the Turkish version of PedsQL 3.0 Arthritis Module: a quality-of-life measure for patients with juvenile idiopathic arthritis in Turkey. Qual Life Res 2013;22(3): 531-6. google scholar
- Wunsch K, C, Niessner C, Schmidt S, Oriwol D, Hanssen-Doose A et al. The Impact of COVID-19 on the Interrelation of Physical Activity, Screen Time, and Health-Related Quality of Life in Children and Adolescents in Germany: Results of the Motorik-Modul Study. Children 2021; 8: 98. google scholar
- Barber MRW, Clarke AE. Systemic lupus erythematosus and risk of infection. Expert Rev Clin Immunol 2020;16(5): 527-38. google scholar
- Hausmann JS, Kennedy K, Simard JF, Liew JW, Sparks JA, Moni TT, et al. Immediate effect of the COVID-19 pandemic on patient health, healthcare use, and behaviors: results from an international survey of people with rheumatic diseases. Lancet Rheumatol 2021;3(10): e707-e14. google scholar
- Leszczyński P. COVID-19: a short message to rheumatologists. Reumatologia 2020;58(3): 130-133. google scholar
- Makowska J, Styrzyński F. Between COVID-19 severity and its prevention–what should rheumatologists be aware of? Reumatologia 2021;59(1): 1-2. google scholar
- Boyarchuk O, Predyk L, Yuryk I. COVID-19 in patients with juvenile idiopathic arthritis: frequency and severity. Reumatologia 2021;59(3): 197-9. google scholar
- Wahezi DM, Jerome D, Rothschild E, Yi B, Dvergsten J, Tarvin S et al. Impact of the COVID-19 pandemic on patients with juvenile idiopathic inflammatory myopathies. Pediatr Rheumatol Online J 2023;21(1): 100. google scholar
- Wilkinson MGL, Wu W, O'Brien K, Deakin CT, Wedderburn LR, Livermore P. A survey to understand the feelings toward and impact of COVID-19 on the households of juvenile dermatomyositis patients from a parent or carer perspective. Rheumatol Adv Pract 2021;5(3): rkab058. google scholar
- Schmidt SCE, Anedda B, Burchartz A, Eichsteller A, Kolb S, C et al. Physical activity and screen time of children and adolescents before and during the COVID-19 lockdown in Germany: a natural experiment. Sci Rep 2020;10(1): 21780. google scholar
- Golberstein E, Wen H, Miller BF. Coronavirus Disease 2019 (COVID-19) and Mental Health for Children and Adolescents. JAMA Pediatr 2020;174:819-820. google scholar
- Hausmann JS, Kennedy K, Surangiwala S, Larche MJ, Sinha R, Durrant K et al. Early impacts of the COVID-19 pandemic on children with pediatric rheumatic diseases. Eur J Rheumatol 2022;9(4):185-190. google scholar
Investigation of COVID-19 impact in children/adolescents with juvenile idiopathic arthritis from a holistic perspective: A controlled trial
Abstract
Objective: The study aimed to examine the effect of coronavirus (COVID-19) exposure on the function and quality of life in children/adolescents with Juvenile Idiopathic Arthritis (JIA).
Materials and Methods: 45 children/adolescents diagnosed with JIA (29 female, 16 male) were included. The impact of coronavirus was questioned with the Numerical Analog Scale, disability level with the Childhood Health Assessment Questionnaire (CHAQ), and quality of life with the Pediatric Quality Of Life Inventory 3.0. Module Arthritis (PedsQL). Participants were divided into two groups: JIA with COVID-19 (n=21) and without COVID-19 (n=24).
Results: The mean age of children/adolescents with JIA’s mean age was 13.16 ± 3.53 and disease duration was 3.58 ±2.93 years. There was no difference in impact from coronavirus, quality of life, and disability level between JIA with COVID-19 (46.7%) and without COVID-19 (53.3%)(p>0.05). General health impact from coronavirus had moderate correlation with quality of life-child (r=-0.371) and high correlation with disability level (r=0.511). Psychosocial impact from coronavirus had moderate correlation with quality of life-child (r=-0.493) and quality of life-parent (r=-0,361) and high correlation with disability level (r=0.536). Activity impact from coronavirus had a moderate correlation with quality of life-child (r=-0.371) and a moderate correlation with disability level (r=0.444).
Conclusion: According to our data results, during the pandemic period, children/adolescents with JIA were affected by the coronavirus at the same level whether they had COVID-19 or not, and their quality of life and disability levels did not change. Coronavirus has affected general health and activity, reducing the quality of life and increasing the level of disability. Psychosocially, it reduced the quality of life of both the child/adolescent with JIA and the parents.
References
- WHO, Coronavirus Disease (COVID-19). World Health Organization, Access date: November 2023, Available from: https://www.who.int/health-topics/ coronavirus#tab=tab_1 google scholar
- Kayis AR, Satici B, Deniz ME, Satici SA, Griffiths MD. Fear of covid-19, loneliness, smartphone addiction, and mental well-being among the Turkish general population: A serial mediation model. Behaviour and Information Technology 2021. google scholar
- Kuy S, Tsai R, Bhatt J, Chu QD, Gandhi P, Gupta R et al. Focusing on Vulnerable Populations During COVID-19. Acad Med 2020;95(11): e2-e3. google scholar
- Bucak IH, Almis H, Tasar SO, Uygun H, Turgut M. Have the sleep habits of the children of health workers been more affected during the COVID-19 pandemic? Sleep Med 2021;83: 235-240. google scholar
- Schmidt SCE, Anedda B, Burchartz A, Eichsteller A, Kolb S, C et al. Physical activity and screen time of children and adolescents before and during the COVID-19 lockdown in Germany: a natural experiment. Sci Rep 2020;10(1):21780. google scholar
- Štveráková T, Jačisko J, Busch A, Šafářová M, Kolář P, Kobesová A. The impact of COVID-19 on the Physical Activity of Czech children. PLoS One 2021;16(7): e0254244. google scholar
- Bansal N, Pasricha C, Kumari P, Jangra S, Kaur R, Singh R. A comprehensive overview of juvenile idiopathic arthritis: From pathophysiology to management. Autoimmun Rev 2023;22(7): 103337. google scholar
- Kelvin AA, Halperin S. COVID-19 in children: the link in the transmission chain. Lancet Infect Dis 2020;20(6): 633-634. google scholar
- Munro APS, Faust SN. Addendum to Children are not COVID-19 super spreaders: time to go back to school. Arch Dis Child 2021;106(2): e9. google scholar
- Durcan G, Barut K, Haslak F, Doktur H, Yildiz M, Adrovic A et al. Psychosocial and clinical effects of the COVID-19 pandemic in patients with childhood rheumatic diseases and their parents. Rheumatol Int 2021;41(3): 575-583. google scholar
- Quéré B, Lemelle I, Lohse A, Pillet P, Molimard J, Richer O et al. Juvenile Idiopathic Arthritis and COVID-19 Pandemic: Good Compliance with Treatment and Reluctance to Return to School. Front Med (Lausanne) 2021;8: 743815. google scholar
- Miserocchi E, Giuffrè C, Modorati GM, Cimaz R. Management of Juvenile idiopathic arthritis-associated uveitis during COVID-19 pandemic in a pediatric referral center in Lombardy. Ocul Immunol Inflamm 2020;28(8): 1305-1307. google scholar
- Fink CW, and the ILAR Task Force for Classification Criteria. A proposal for developing classification criteria for the idiopathic arthritides of childhood. J Rheumatol 1995;22:1566–9 google scholar
- Smith BW, Zautra AJ. Effects of anxiety and depression on weekly pain in women with arthritis. Pain 2005;115(3):358-365 google scholar
- Ozdogan H, Ruperto N, Kasapçopur O, Bakkaloglu A, Arisoy N, Ozen S et al. The Turkish version of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ). Clin Exp Rheumatol 2001;19(4 Suppl 23): S158-62. google scholar
- Tarakci E, Baydogan SN, Kasapcopur O, Dirican A. Cross-cultural adaptation, reliability, and validity of the Turkish version of PedsQL 3.0 Arthritis Module: a quality-of-life measure for patients with juvenile idiopathic arthritis in Turkey. Qual Life Res 2013;22(3): 531-6. google scholar
- Wunsch K, C, Niessner C, Schmidt S, Oriwol D, Hanssen-Doose A et al. The Impact of COVID-19 on the Interrelation of Physical Activity, Screen Time, and Health-Related Quality of Life in Children and Adolescents in Germany: Results of the Motorik-Modul Study. Children 2021; 8: 98. google scholar
- Barber MRW, Clarke AE. Systemic lupus erythematosus and risk of infection. Expert Rev Clin Immunol 2020;16(5): 527-38. google scholar
- Hausmann JS, Kennedy K, Simard JF, Liew JW, Sparks JA, Moni TT, et al. Immediate effect of the COVID-19 pandemic on patient health, healthcare use, and behaviors: results from an international survey of people with rheumatic diseases. Lancet Rheumatol 2021;3(10): e707-e14. google scholar
- Leszczyński P. COVID-19: a short message to rheumatologists. Reumatologia 2020;58(3): 130-133. google scholar
- Makowska J, Styrzyński F. Between COVID-19 severity and its prevention–what should rheumatologists be aware of? Reumatologia 2021;59(1): 1-2. google scholar
- Boyarchuk O, Predyk L, Yuryk I. COVID-19 in patients with juvenile idiopathic arthritis: frequency and severity. Reumatologia 2021;59(3): 197-9. google scholar
- Wahezi DM, Jerome D, Rothschild E, Yi B, Dvergsten J, Tarvin S et al. Impact of the COVID-19 pandemic on patients with juvenile idiopathic inflammatory myopathies. Pediatr Rheumatol Online J 2023;21(1): 100. google scholar
- Wilkinson MGL, Wu W, O'Brien K, Deakin CT, Wedderburn LR, Livermore P. A survey to understand the feelings toward and impact of COVID-19 on the households of juvenile dermatomyositis patients from a parent or carer perspective. Rheumatol Adv Pract 2021;5(3): rkab058. google scholar
- Schmidt SCE, Anedda B, Burchartz A, Eichsteller A, Kolb S, C et al. Physical activity and screen time of children and adolescents before and during the COVID-19 lockdown in Germany: a natural experiment. Sci Rep 2020;10(1): 21780. google scholar
- Golberstein E, Wen H, Miller BF. Coronavirus Disease 2019 (COVID-19) and Mental Health for Children and Adolescents. JAMA Pediatr 2020;174:819-820. google scholar
- Hausmann JS, Kennedy K, Surangiwala S, Larche MJ, Sinha R, Durrant K et al. Early impacts of the COVID-19 pandemic on children with pediatric rheumatic diseases. Eur J Rheumatol 2022;9(4):185-190. google scholar
Details
| Primary Language | English |
|---|---|
| Subjects | Pediatric Rheumatology |
| Journal Section | Research Article |
| Authors | |
| Publication Date | July 8, 2025 |
| Submission Date | May 3, 2024 |
| Acceptance Date | January 23, 2025 |
| Published in Issue | Year 2025 Volume: 25 Issue: 1 |