Could uric acid to high density lipoprotein-cholesterol ratio be considered as a marker of hemodialysis sufficiency?

Year 2023, Volume: 13 Issue: 1, 86 - 91, 31.01.2023

Mustafa Çapraz Orhan Coşkun

https://doi.org/10.16899/jcm.1223641

Abstract

Aim: Hemodialysis (HD) is one of the most widely utilized renal replacement therapies in individuals with end-stage chronic kidney disease (CKD). The purpose of this study was to compare the Uric acid to HDL cholesterol ratio (UHR) levels of well-treated HD patients to those of those who had inadequate HD therapy.
Materials and Methods: Data on HD patients were acquired from patient files and the institution's database. A URR value of more than 70% designated the sufficient HD group, whereas less than 70% defined the insufficient HD group. Furthermore, laboratory data, such as the UHR of the study groups, were compared.
Results: The UHRs for adequate and inadequate HD were 0.160±04 and 0.20±0.07, respectively. The UHR of patients with insufficient HD was substantially greater than that of the subjects with sufficient HD (p=0.004). Besides, UHR was substantially and positively connected with urea before HD (r=0.37, p=0.001), urea after HD (r=0.39, p=0.001), serum creatinine before HD (r=0.48, p0.001), serum creatinine after HD (r=0.45, p0.001), and negatively correlated with URR (r=-0.29, p=0.008), according to correlation analyses. In individuals with chronic renal disease, a UHR value higher than 0.16 exhibited 67% sensitivity and 57% specificity in detecting inadequate HD.
Conclusion: We propose that UHR, in addition to URR, might be used to determine HS sufficiency in CKD patients undergoing HD therapy.

Keywords

Hemodialysis, uric acid to HDL cholesterol ratio, urea reduction ratio

Ürik asit yüksek yoğunluklu lipoprotein-kolesterol oranı, hemodiyaliz yeterliliğinin bir belirteci olarak kabul edilebilir mi?

Abstract

Amaç: Hemodiyaliz (HD), son dönem kronik böbrek hastalığı (KBH) olan bireylerde en yaygın kullanılan renal replasman tedavilerinden biridir. Bu çalışmanın amacı, iyi tedavi edilen HD hastalarının Ürik asit / HDL kolesterol oranı (UHR) düzeylerini, yetersiz HD tedavisi almayanlarınkilerle karşılaştırmaktı.
Gereç ve Yöntem: HD hastalarına ilişkin veriler, hasta dosyalarından ve kurumun veri tabanından elde edildi. URR değerinin %70'in üzerinde olması yeterli HD grubunu, %70'in altında olması ise yetersiz HD grubunu tanımlamıştır. Ayrıca, çalışma gruplarının UHR'si gibi laboratuvar verileri karşılaştırıldı.
Bulgular: Yeterli ve yetersiz HD için UHR'ler sırasıyla 0,160±04 ve 0,20±0,07 idi. Yetersiz HD'si olan hastaların UHR'si, yeterli HD'si olan deneklerden önemli ölçüde daha yüksekti (p=0.004). Ayrıca UHR, HD öncesi üre (r=0,37, p=0,001), HD sonrası üre (r=0,39, p=0,001), HD öncesi serum kreatinin (r=0,48, p0,001), serum Korelasyon analizlerine göre HD sonrası kreatinin (r=0.45, p0.001) ve URR ile negatif korelasyon (r=-0.29, p=0.008). Kronik böbrek hastalığı olan bireylerde, 0,16'dan yüksek bir UHR değeri, yetersiz HD'yi saptamada %67 duyarlılık ve %57 özgüllük sergilemiştir.
Sonuç: HD tedavisi gören KBH hastalarında HS yeterliliğini belirlemek için URR'ye ek olarak UHR'nin kullanılabileceğini öneriyoruz.

Keywords

Hemodiyaliz, Ürik Asit HDL oranı, Üre düşüş oranı

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