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GESTASYONEL DİYABETLİ KADINLARDA ORTALAMA PLATELET HACMİ VE 25 HİDROKSİ D VİTAMİNİ DÜZEYLERİNİN DEĞERLENDİRİLMESİ.

Year 2024, Volume: 14 Issue: 4, 168 - 173, 31.07.2024
https://doi.org/10.16899/jcm.1463530

Abstract

Amaç: Gestasyonel diyabeti olan hastalarda ortalama trombosit hacmi (MPV) ve 25-OH hidroksi vitamin D düzeylerini değerlendirmeye çalışan az sayıdaki çalışmaya göre, çelişkili sonuçlar ortaya çıkmıştır. Bu çalışmada gestasyonel diyabetik ve sağlıklı gebelerde MPV ve serum 25-OH vitamin D düzeylerini değerlendirmeyi ve karşılaştırmayı amaçladık.
Gereç ve Yöntem: Hastalar Okmeydanı Eğitim ve Araştırma Hastanesi Kadın Hastalıkları ve Doğum, Diyabet ve Endokrinoloji polikliniklerinden gestasyonel diyabet taraması ve oral glukoz tolerans testi yapılmış 24-28 haftalık gebelerden seçildi. Araştırma sonucunda 52 gestasyonel diyabet hastası ve 52 sağlıklı gebe çalışmaya dahil edildi. MPV ve D vitamini seviyeleri tespit edildi. Ayrıca hastaların demografik ve klinik verileri kaydedildi.
Bulgular: Çalışmaya alınan gestasyonel diyabetik gebe grubunun ortalama MPV değeri 8,5 ± 1,0 fl; kontrol grubunda ise ortalama MPV 8,3 ± 1,1 fl saptandı. Çalışmaya alınan hasta grubu ile kontrol grubu arasında ortalama MPV değeri dağılımda istatistiksel olarak anlamlı bir farklılık görülmedi (p>0,05). Gestasyonel diyabetik gebe grubunun ortalama 25-OH vitamin D değeri 20,5 ± 11,0 ng/ml; kontrol grubunda ise 21,1 ± 9,3 ng/ml saptandı. Çalışmaya alınan hasta grubu ile kontrol grubu arasında ortalama 25-OH vitamin D değeri dağılımda istatiksel olarak anlamlı bir farklılık görülmedi (p>0,05)
Sonuç: Bizim çalışmamızda gestasyonel diyabetik gebe grubu ile sağlıklı gebe grubu arasında MPV ve 25-OH vitamin düzeyleri arasında istatistiksel olarak anlamlı bir fark saptanmadı.

Project Number

no

References

  • 1. Turok DK, Ratcliffe SD, Baxley EG. Management of gestational diabetes mellitus. Am Fam Physician 2003; 68(9):1767-72.
  • 2. Kim C, Tabaei BP, Burke R, McEwen LN, Lash RW, Johnson SL, et al. Missed opportunities for type 2 diabetes mellitus screening among women with a history of gestational diabetes mellitus. Am J Public Health 2006; 96(9):1643-8.
  • 3. Guariguata L, Linnenkamp U, Beagley J, Whiting DR, Cho NH. Global estimates of the prevalence of hyperglycaemia in pregnancy for 2013 for the IDF Diabetes Atlas. Diabetes Res Clin Pract 2013.
  • 4. Pöyhönen-Alho M, Joutsi-Korhonen L, Lassila R, Kaaja R. Alterations of sympathetic nervous system, coagulation and platelet function in gestational diabetes. Blood Coagul Fibrinolysis 2012; 23(6):508-13.
  • 5. Stein PD, Goldman J, Matta F, Yaekoub AY. Diabetes mellitus and risk of venous thromboembolism. Am J Med Sci 2009; 337(4): 259-64.
  • 6. Erikçi AA, Muhçu M, Dündar O, Oztürk A. Could mean platelet volume be a predictive marker for gestational diabetes mellitus? Hematology 2008;13(1): 46-8.
  • 7. Holmes VA, Barnes MS, Alexander HD, McFaul P, Wallace JM. Vitamin D deficiency and insufficiency in pregnant women: a longitudinal study. Br J Nutr 2009;102(6):876-881.
  • 8. Takiishi T, Gysemans C, Bouillon R, Mathieu C. Vitamin D and diabetes. Endocrinol Metab Clin North Am 2010;39(2):419-446.
  • 9. Maghbooli Z, Hossein-Nezhad A, Karimi F, Shafaei AR, Larijani B. Correlation between vitamin D3 deficiency and insulin resistance in pregnancy. Diabetes Metab Res Rev 2008;24(1):27-32.
  • 10. Farrant HJ, Krishnaveni GV, Hill JC, Boucher BJ, Fisher DJ, Noonan K, et al. Vitamin D insufficiency is common in Indian mothers but is not associated with gestational diabetes or variation in newborn size. Eur J Clin Nutr 2009;63(5):646-652.
  • 11. Zhang C, Qiu C, Hu FB, David RM, van Dam RM, Bralley A, et al. Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PLoS One 2008;3(11):e3753.
  • 12. Bancroft AJ, Abel W, M McLaren, JJF Belch. Mean trombosit volume is a useful parameter: a reproducible routine method using a modified Coulter Thrombocytometer. Trombosits 2000;11:379-387.
  • 13. Şenaran H, İleri M, Altınbaş A, et al.Thrombopoietin and mean trombosit volume in coronary artery disease. Clin Cardiol 2001;24:405-408.
  • 14. Winocour PD. Platelet turnover in advanced diabetes. Eur J Clin Invest 1994;24 (Suppl 1):34-7.
  • 15. Pizulli L, Yang A, Martin jf, et al. Changes n trombosit size and count in unstable anjina compared to stable anjina or non cardiac chest pain. European Heart Journal 1998;19:80-84.
  • 16. Dow RB. The Clinical and laboratory utility of trombosit volume parameters. Jnl Medical Science 1994;15:1-15. 17. Bath PM, Butterworth RJ. Trombosit size: measurement, physiology and vascular disease.Blood Coagulation and Fibrinolysis 1996;7.157-161.
  • 18. Jackson SR, Carter JM. Trombosit volume: laboratory measurement and clinical application. Blood Reviews 1993;7:104-113.
  • 19. Tschope D, Langer E, Schauseil S, et al. Increased trombosit volume sign of impaired thrombopoesis in diabetes mellitus. Klin Wochenschr 1989;15;67(4):253-9.
  • 20. Sharp PC, Trinick T. Mean trombosit volume in diabetes mellitus. Quarterly Journal of Medicine 1993;86:739-742.
  • 21. Vignini A, Moroni C, Nanetti L, et al. Alterations of platelet biochemical and functional properties in newly diagnosed type 1 diabetes: a role in cardiovascular risk? Diabetes Metab Res Rev 2011; 27(3): 277-85
  • 22. Hekimsoy Z, Payzin B, Ornek T, Kandoğan G. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications 2004;18(3):173-6.
  • 23. Coban E, Bostan F, Ozdogan M. The mean platelet volume in subjects with impaired fasting glucose. Platelets 2006;17(1):67-9.
  • 24. Bozkurt N, Yilmaz E, Biri A, Taner Z, Himmetoğlu O. The mean platelet volume in gestational diabetes. J Thromb Thrombolysis 2006; 22(1):51-4.
  • 25. Balkan F, Usluoğulları CA, Üçler R, Usluoğulları B, Caner S. Mean platelet volume (MPV): could it be used as a predictive marker for gestational diabetes? Gaziantep Med J 2014; 20(2):123-125.
  • 26. Sönmez A, Kutlu M. Current recommendations for gestational diabetes screening. Turkiye Klinikleri J Endocrin-Special Topics 2010;3(1):1-5.
  • 27. Ponsonby AL, Lucas RM, Lewis S, Halliday J. Vitamin D status during pregnancy and aspects of offspring health. Nutrients 2010;2(3):389-407.
  • 28. Hekimsoy Z, Dinç G, Kafesçiler S, et al. Vitamin D status among adults in the Aegean region of Turkey. BMC Public Health 2010;10:782.
  • 29. Baker AM, Haeri S, Camargo CA Jr, Stuebe AM, Boggess KA. First-trimester maternal vitamin D status and risk for gestational diabetes (GDM) a nested case-control study. Diabetes Metab Res Rev 2012;28(2):164-168.
  • 30. Makgoba M, Nelson SM, Savvidou M, Messow CM, Nicolaides K, Sattar N. First-trimester circulating 25-hydroxyvitamin D levels and development of gestational diabetes mellitus. Diabetes Care 2011;34(5):1091-1093.
  • 31. Soheilykhah S, Mojibian M, Rashidi M, Rahimi-Saghand S, Jafari F. Maternal vitamin D status in gestational diabetes mellitus. Nutr Clin Pract 2010;25(5):524-527.
  • 32. Eastell R, Arnold A, Brandi ML, et al. Diagnosis of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop. J Clin Endocrinol Metab 2009;94(2):340-350.
  • 33. Perez-Ferre N, Torrejon MJ, Fuentes M, et al. Association of low serum 25-Hydroxyvitamin D levels in pregnancy with glucose homeostasis and obstetric and newborn outcomes. Endocr Pract 2012:1-18.
  • 34. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin d deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2011;96(7):1911-1930.

EVALUATION OF MEAN PLATELET VOLUME AND 25 HYDROXY VITAMIN D LEVELS IN GESTATIONAL DIABETIC WOMEN

Year 2024, Volume: 14 Issue: 4, 168 - 173, 31.07.2024
https://doi.org/10.16899/jcm.1463530

Abstract

Aim: According to few studies which tried to evaluate mean platelet volume (MPV) and 25 hydroxy vitamin D, have shown conflicting results in gestational diabetic patients. In this study we aimed to compare main platelet volume and 25 hydroxy vitamin D values between gestational diabetic patients and healty individual pregnant womens.
Material and method: The patients were selected from 24-28 weeks pregnant people who made gestational diabetes screening and oral glucose tolerance test from obstetric-gynecology, diabetes and endocrinology polyclinics of Okmeydanı Training and Research Hospital. After the searching 52 gestational diabetic patients and 52 healty pregnant women included to the study. We estimated MPV and vitamin D level. In addition, demographic and clinical data of subjects were recorded.
Results: Mean platelet volume (MPV) value was found 8,5 ± 1,0 fl and 8,3 ± 1,1 fl. in gestational diabetic and control group respectively. There was no statistically significant differences in MPV value between case and the control group (p>0.05). Mean 25 hydroxy vitamin D value was found 20.5 ± 11.0 ng/ml and 21,1 ± 9,3 ng/ml. gestational diabetic and control group respectively. There was no statistically significant differences in 25 hydroxy (OH) vitamin D value between case and control group.
Conclusion: In our study we found no statistically significant differences in MPV and 25-OH vitamin D values between gastational diabetic pregnant group and healty pregnant group.

Project Number

no

References

  • 1. Turok DK, Ratcliffe SD, Baxley EG. Management of gestational diabetes mellitus. Am Fam Physician 2003; 68(9):1767-72.
  • 2. Kim C, Tabaei BP, Burke R, McEwen LN, Lash RW, Johnson SL, et al. Missed opportunities for type 2 diabetes mellitus screening among women with a history of gestational diabetes mellitus. Am J Public Health 2006; 96(9):1643-8.
  • 3. Guariguata L, Linnenkamp U, Beagley J, Whiting DR, Cho NH. Global estimates of the prevalence of hyperglycaemia in pregnancy for 2013 for the IDF Diabetes Atlas. Diabetes Res Clin Pract 2013.
  • 4. Pöyhönen-Alho M, Joutsi-Korhonen L, Lassila R, Kaaja R. Alterations of sympathetic nervous system, coagulation and platelet function in gestational diabetes. Blood Coagul Fibrinolysis 2012; 23(6):508-13.
  • 5. Stein PD, Goldman J, Matta F, Yaekoub AY. Diabetes mellitus and risk of venous thromboembolism. Am J Med Sci 2009; 337(4): 259-64.
  • 6. Erikçi AA, Muhçu M, Dündar O, Oztürk A. Could mean platelet volume be a predictive marker for gestational diabetes mellitus? Hematology 2008;13(1): 46-8.
  • 7. Holmes VA, Barnes MS, Alexander HD, McFaul P, Wallace JM. Vitamin D deficiency and insufficiency in pregnant women: a longitudinal study. Br J Nutr 2009;102(6):876-881.
  • 8. Takiishi T, Gysemans C, Bouillon R, Mathieu C. Vitamin D and diabetes. Endocrinol Metab Clin North Am 2010;39(2):419-446.
  • 9. Maghbooli Z, Hossein-Nezhad A, Karimi F, Shafaei AR, Larijani B. Correlation between vitamin D3 deficiency and insulin resistance in pregnancy. Diabetes Metab Res Rev 2008;24(1):27-32.
  • 10. Farrant HJ, Krishnaveni GV, Hill JC, Boucher BJ, Fisher DJ, Noonan K, et al. Vitamin D insufficiency is common in Indian mothers but is not associated with gestational diabetes or variation in newborn size. Eur J Clin Nutr 2009;63(5):646-652.
  • 11. Zhang C, Qiu C, Hu FB, David RM, van Dam RM, Bralley A, et al. Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PLoS One 2008;3(11):e3753.
  • 12. Bancroft AJ, Abel W, M McLaren, JJF Belch. Mean trombosit volume is a useful parameter: a reproducible routine method using a modified Coulter Thrombocytometer. Trombosits 2000;11:379-387.
  • 13. Şenaran H, İleri M, Altınbaş A, et al.Thrombopoietin and mean trombosit volume in coronary artery disease. Clin Cardiol 2001;24:405-408.
  • 14. Winocour PD. Platelet turnover in advanced diabetes. Eur J Clin Invest 1994;24 (Suppl 1):34-7.
  • 15. Pizulli L, Yang A, Martin jf, et al. Changes n trombosit size and count in unstable anjina compared to stable anjina or non cardiac chest pain. European Heart Journal 1998;19:80-84.
  • 16. Dow RB. The Clinical and laboratory utility of trombosit volume parameters. Jnl Medical Science 1994;15:1-15. 17. Bath PM, Butterworth RJ. Trombosit size: measurement, physiology and vascular disease.Blood Coagulation and Fibrinolysis 1996;7.157-161.
  • 18. Jackson SR, Carter JM. Trombosit volume: laboratory measurement and clinical application. Blood Reviews 1993;7:104-113.
  • 19. Tschope D, Langer E, Schauseil S, et al. Increased trombosit volume sign of impaired thrombopoesis in diabetes mellitus. Klin Wochenschr 1989;15;67(4):253-9.
  • 20. Sharp PC, Trinick T. Mean trombosit volume in diabetes mellitus. Quarterly Journal of Medicine 1993;86:739-742.
  • 21. Vignini A, Moroni C, Nanetti L, et al. Alterations of platelet biochemical and functional properties in newly diagnosed type 1 diabetes: a role in cardiovascular risk? Diabetes Metab Res Rev 2011; 27(3): 277-85
  • 22. Hekimsoy Z, Payzin B, Ornek T, Kandoğan G. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications 2004;18(3):173-6.
  • 23. Coban E, Bostan F, Ozdogan M. The mean platelet volume in subjects with impaired fasting glucose. Platelets 2006;17(1):67-9.
  • 24. Bozkurt N, Yilmaz E, Biri A, Taner Z, Himmetoğlu O. The mean platelet volume in gestational diabetes. J Thromb Thrombolysis 2006; 22(1):51-4.
  • 25. Balkan F, Usluoğulları CA, Üçler R, Usluoğulları B, Caner S. Mean platelet volume (MPV): could it be used as a predictive marker for gestational diabetes? Gaziantep Med J 2014; 20(2):123-125.
  • 26. Sönmez A, Kutlu M. Current recommendations for gestational diabetes screening. Turkiye Klinikleri J Endocrin-Special Topics 2010;3(1):1-5.
  • 27. Ponsonby AL, Lucas RM, Lewis S, Halliday J. Vitamin D status during pregnancy and aspects of offspring health. Nutrients 2010;2(3):389-407.
  • 28. Hekimsoy Z, Dinç G, Kafesçiler S, et al. Vitamin D status among adults in the Aegean region of Turkey. BMC Public Health 2010;10:782.
  • 29. Baker AM, Haeri S, Camargo CA Jr, Stuebe AM, Boggess KA. First-trimester maternal vitamin D status and risk for gestational diabetes (GDM) a nested case-control study. Diabetes Metab Res Rev 2012;28(2):164-168.
  • 30. Makgoba M, Nelson SM, Savvidou M, Messow CM, Nicolaides K, Sattar N. First-trimester circulating 25-hydroxyvitamin D levels and development of gestational diabetes mellitus. Diabetes Care 2011;34(5):1091-1093.
  • 31. Soheilykhah S, Mojibian M, Rashidi M, Rahimi-Saghand S, Jafari F. Maternal vitamin D status in gestational diabetes mellitus. Nutr Clin Pract 2010;25(5):524-527.
  • 32. Eastell R, Arnold A, Brandi ML, et al. Diagnosis of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop. J Clin Endocrinol Metab 2009;94(2):340-350.
  • 33. Perez-Ferre N, Torrejon MJ, Fuentes M, et al. Association of low serum 25-Hydroxyvitamin D levels in pregnancy with glucose homeostasis and obstetric and newborn outcomes. Endocr Pract 2012:1-18.
  • 34. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin d deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2011;96(7):1911-1930.
There are 33 citations in total.

Details

Primary Language English
Subjects Endocrinology
Journal Section Original Research
Authors

Kadri Turan 0000-0003-2854-3210

Mine Adaş 0000-0003-3008-6581

Edip Erkuş 0000-0002-7821-8275

Murat Kahramaner 0000-0002-8846-0276

Project Number no
Publication Date July 31, 2024
Submission Date April 2, 2024
Acceptance Date July 22, 2024
Published in Issue Year 2024 Volume: 14 Issue: 4

Cite

AMA Turan K, Adaş M, Erkuş E, Kahramaner M. EVALUATION OF MEAN PLATELET VOLUME AND 25 HYDROXY VITAMIN D LEVELS IN GESTATIONAL DIABETIC WOMEN. J Contemp Med. July 2024;14(4):168-173. doi:10.16899/jcm.1463530