j cell neurosci oxid stress Journal of Cellular Neuroscience and Oxidative Stress 2149-7222 Yasemin NAZIROĞLU 10.37212/jcnos.584625 Medical and Biological Physics Tıbbi ve Biyolojik Fizik Mouse models for retinal degeneration Shu Xinhua School of Health and Life Sciences of Glasgow Caledonian University, Glasgow, Scotland 06 21 2019 11 0 4 4 04 01 2019 04 11 2019 Copyright © 2008, Journal of Cellular Neuroscience and Oxidative Stress 2008 Journal of Cellular Neuroscience and Oxidative Stress

Retina is a part of central nervous system. Retinal degeneration is characterized by the death of photoreceptor cells, causing partial vision loss or even blindness. Retinal degeneration includes inherited retinal degeneration such as retinitis pigmentosa (RP) and complex retinal degeneration such as diabetic retinopathy. In this talk, I will discuss the disease mechanisms and current treatment of inherited retinal degeneration. I will also discuss techniques for retinal degeneration in mouse models.  I will demonstrate how to dissect mouse retina and retinal pigment epithelial (RPE) cells.   

 Retinal degeneration Diabetes Retinal pigment epithelial Mouse 1: Zhang X, Shahani U, Reilly J, Shu X. Disease mechanisms and neuroprotection by tauroursodeoxycholic acid in Rpgr knockout mice. J Cell Physiol. 2019 Mar 28. doi: 10.1002/jcp.28519. [Epub ahead of print] PubMed PMID: 30924157. 2: Alamri A, Biswas L, Watson DG, Shu X. Deletion of TSPO Resulted in Change of Metabolomic Profile in Retinal Pigment Epithelial Cells. Int J Mol Sci. 2019;20(6). pii: E1387.