Is Hypericum perforatum agonist or antagonist of TRPC6 in neurons?

Year 2016, Volume: 8 Issue: 2, 595 - 600, 31.12.2016

Mustafa Nazıroğlu

https://doi.org/10.37212/jcnos.334114

Cited By: 1

Abstract

Transient receptor potential canonical 6
(TRPC6) channel is a family of transient receptor superfamily. Hyperforin is an
active component of Hypericum species including Hypericum perforatum (HPer). In the review paper, the author summarizes the recent information between
TRPC6-induced Ca²⁺ entry, HPer and hyperforin to understand the
etiology of the neurological diseases and potential therapeutic strategies.

The TRPC6 in several cell types is activated by
2-Aminoethoxydiphenylborane (2-APB), 4,5 triphosphate (IP₃)  and diacylglycerol (DAG) pathways, although it
was inhibited in the cells by several non-specific antagonists including
gadolinium and lanthanum. Results of limited studies indicated that hyperforin
caused intracellular Ca²⁺ elevations through TRPC6 activation in
neurons and cells, although the intracellular
Ca²⁺ elevation results were
not confirmed by many recent studies. Release Ca²⁺ from internal stores instead of extracellular Ca²⁺
entry through activation of TRPC6 channel in neurons of brain was also
reported. The TRPC6-induced Ca²⁺ influx was inhibited in brain by
active components of some antioxidants.

In conclusion, the present literature
information shows that interaction between TRPC6-induced
Ca²⁺ entry and hyperforin in neurons and cell lines are too complex and it has not been
clarified yet.

Keywords

TRPC6, Hypericum perforatum, Hyperforin, Calcium ion

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