Blepharospasm induced by systemic isotretinoin

Year 2019, Volume: 10 Issue: 2, 33 - 35, 01.04.2019

Gülhan Gülhan Gürel Hikmet Sacmacı

https://doi.org/10.33706/jemcr.550841

Abstract

Introduction:Isotretinoin
(13-cis-retinoic acid), a synthetic analog of vitamin A, is commonly used in
the treatment of nodulocytic acne, which is resistant to other treatments. The
most common side effects of systemic isotretinoin treatment are dry mucous
membranes and dry skin. Blepharospasm is a movement disorder characterized by
hyperactivity of orbicularis oculi and other muscles around the eye.

Case
Report: We report here  a 33-year-old
female patient developed blepharospasm during treatment with systemic
isotretinoin. She consulted an ophthalmologist about her eye problem and was
diagnosed as having ‘dry eye’. Blepharospasm did not improve even though she
received artificial tears treatment. Magnetic resonance imaging and magnetic
resonance angiography were performed to investigate the etiology of
blepharospasm and no pathological findings were found.

Conclusion:
We
present a case of blepharospasm due to isotretinoin. Based on PubMed database,
this is the first clinical case of blepharospasm induced by isotretinoin. 

Keywords

Blepharospasm, isotretinoin

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