j. fac. pharm. ankara Journal of Faculty of Pharmacy of Ankara University 1015-3918 2564-6524 Ankara University 10.33483/jfpau.1033286 Pharmacology and Pharmaceutical Sciences Eczacılık ve İlaç Bilimleri NATURE-INSPIRED BIOMIMETIC NANOCARRIER SYSTEMS DOĞADAN İLHAM ALAN BİYOMİMETİK NANOTAŞIYICI SİSTEMLER https://orcid.org/0000-0003-0593-8586 Aydın Ezgi İZMİR KATİP ÇELEBİ ÜNİVERSİTESİ https://orcid.org/0000-0001-7656-0969 Aydın Ali İZMİR KATİP ÇELEBİ ÜNİVERSİTESİ https://orcid.org/0000-0001-9557-9008 Çetiner Gizem İZMİR KATİP ÇELEBİ ÜNİVERSİTESİ https://orcid.org/0000-0003-3287-5277 Erel Akbaba Gülşah İZMİR KATİP ÇELEBİ ÜNİVERSİTESİ 05 29 2022 46 2 551 575 12 06 2021 03 31 2022 Copyright © 1971, Journal of Faculty of Pharmacy of Ankara University 1971 Journal of Faculty of Pharmacy of Ankara University

Objective: Nanoparticular systems such as polymeric and lipidic nanoparticles, which are frequently used in synthetic, biological and biotechnological drug delivery, struggle to meet clinical expectations at the desired level. Nature-inspired biomimetic nanocarriers developed as an innovative approach, are increasingly included in studies due to their high biocompatibility, low toxicity, and natural targeting capabilities. The aim of this review is to contribute to the development of innovative pharmaceutical carrier system by addressing the current studies in the field of biomimetic nanocarriers.Result and Discussion: Among the most commonly used biomimetic systems are virus-based, mammalian cell-based and bacteria-fungi-based nanocarrier systems. The effort to understand these systems that nature offers us could take us further in carrier system research. Moreover, there may be potential for more successful nanocarrier systems to be developed by combining the advantages of synthetic systems such as controllability and mass production with the high cellular uptake and biocompatibility functions of biological systems. Thus, the role of biomimetic systems in the transport of proteins, genes and other therapeutic agents will increase.

Amaç: Sentetik, biyolojik ve biyoteknolojik ilaç araştırmalarında sıklıkla kullanılan polimerik ve lipidik yapıdaki nanopartiküler sistemler klinik beklentileri halen istenilen düzeyde karşılayamamaktadır. Yenilikçi bir yaklaşım olarak geliştirilen doğadan ilham alan, biyomimetik nanotaşıyıcılar sahip oldukları yüksek biyouyumluluk, düşük toksisisite ve doğal hedefleme yetenekleri nedeniyle gittikçe artan şekilde çalışmalara dahil edilmektedir. Bu derlemenin amacı biyomimetik nanotaşıyıcılar alanında yapılan güncel çalışmaları ele alarak farmasötik yenilikçi taşıyıcı system geliştirme çabasına katkıda bulunmaktır.Sonuç ve Tartışma: En sık kullanılan biyomimetik sistemler arasında virüs temelli, memeli hücresi temelli ve bakteri-mantar temelli nanotaşıyıcı sistemler bulunmaktadır. Doğanın bize sunduğu bu sistemleri anlama çabası taşıyıcı sistem araştırmalarında bizi daha ileriye götürebilir. Bununla birlikte, kontrol edilebilirlik ve seri üretim gibi sentetik sistemlerin avantajları ile biyolojik sistemlerin yüksek hücresel alım ve biyouyumluluk işlevlerinin birleştirmesi ile daha başarılı nanotaşıyıcı sistemlerin geliştirilme potansiyeli olabilecektir. Böylece, biyomimetik sistemlerin protein, gen ve diğer terapötik ajanların taşınmasındaki rolü artacaktır.

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