j. fac. pharm. ankara

Journal of Faculty of Pharmacy of Ankara University

1015-3918 2564-6524

Ankara University

10.33483/jfpau.1216758

Pharmacology and Pharmaceutical Sciences

Eczacılık ve İlaç Bilimleri

POLİETİLEN OKSİT/SODYUM ALJİNAT BONCUKLARININ VE/VEYA LİFLERİNİN ÜRETİMİ VE MORFOLOJİK KONTROLÜ: ELEKTROEĞİRMEDE VİSKOZİTE VE İLETKENLİĞİN ETKİSİ

FABRICATION AND CONTROLLING MORPHOLOGY OF POLYETHYLENE OXIDE/SODIUM ALGINATE BEADS AND/OR FIBERS: EFFECT OF VISCOSITY AND CONDUCTIVITY IN ELECTROSPINNING

https://orcid.org/0000-0003-4610-6882

Eren Böncü

Tuğba

ERCIYES UNIVERSITY, FACULTY OF PHARMACY

05 20 2023

47 2 420 429 12 13 2022 02 04 2023

1971

Journal of Faculty of Pharmacy of Ankara University

Amaç: Çalışmanın amacı, PEO/NaAlg polimer çözeltilerinin viskozite ve iletkenliklerini belirlemek, PEO/NaAlg boncukları, boncuk-iplik lifleri ve lifleri elektroeğirme yöntemiyle formüle etmek ve bunlar üzerinde ileri morfolojik karakterizasyon çalışmaları yapmaktır.Gereç ve Yöntem: PEO ve NaAlg derişiminin ve oranlarının çözeltilerin eğrilebilirliği, viskozitesi ve iletkenliği ve ayrıca PEO/NaAlg elektroeğrilmiş liflerin ve boncukların morfolojik özellikleri (boncukların uzunluğu, genişliği ve en boy oranı, boncuk sayısı) üzerindeki etkisi incelenmiştir.Sonuç ve Tartışma: Sonuç olarak, doku mühendisliği, yara örtüsü, ilaç taşıyıcı sistem gibi tıbbi ve biyolojik uygulamalar için değerli olan PEO/NaAlg boncuklar ve/veya lifler elektroeğirme yöntemiyle üretilmiştir. Çözeltilerin viskozite ve iletkenliği ile üretilen materyalin morfolojik özelliklerinin PEO ve NaAlg derişiminden ve oranlarından etkilendiği bulunmuştur. PEO varlığında iletkenlikteki artış sayesinde eğrilebilirlik iyileştirilmiştir. Daha düşük viskozite ve iletkenlik, genellikle daha küçük, daha fazla sayıda ve daha büyük alana sahip boncukların üretilmesine neden olmuştur. PEO/NaAlg elektroeğrilmiş materyallerin morfolojik özellikleri, çalışmada incelenen parametreler kontrol edilerek değiştirilebilir.

Objective: The aim of the study is to determine the viscosity and conductivity of PEO/NaAlg polymer solutions, to formulate PEO/NaAlg beads, bead-on-string fibers and fibers via electrospinning, and to perform advanced morphological characterization studies on them.Material and Method: Effect of PEO and NaAlg concentration and ratio of them on spinnability, viscosity and conductivity of solutions, and also on the morphological properties of PEO/NaAlg electrospun fibers, and beads (length, width and aspect ratio of beads, number of beads and bead area) were investigated.Result and Discussion: As a result, electrospun materials were produced using PEO/NaAlg beads and/or fibers, which are valuable for medical and biological applications such as tissue engineering, wound dressing, drug delivery system. Viscosity and conductivity of solutions, and morphological properties of the obtained materials were found to be affected by PEO and NaAlg concentration and the ratio of them. Spinnability was improved thanks to the increase in conductivity in the presence of PEO. The lower viscosity and conductivity resulted in the production of beads that were generally smaller and greater in number in the material and having higher area. The morphological properties of PEO/NaAlg electrospun materials can be modified by controlling the parameters examined in the study.

Conductivity electrospinning electrospun beads polyethylene oxide (PEO)/sodium alginate (NaAlg) viscosity

Elektrik iletkenliği elektroeğirme elektroeğrilmiş boncuklar polietilen oksit(PEO)/sodyum aljinat (NaAlj) viskozite

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