j. fac. pharm. ankara

Journal of Faculty of Pharmacy of Ankara University

1015-3918 2564-6524

Ankara University

10.33483/jfpau.1464247

Pharmaceutical Sciences Pharmaceutical Delivery Technologies

Eczacılık Bilimleri İlaç Dağıtım Teknolojileri

UTILIZATION OF POLYDOPAMINE-BASED NANOSYSTEMS AS DRUG DELIVERY SYSTEMS AND THEIR THERAPEUTIC POTENTIALS

POLİDOPAMİN TEMELLİ NANOSİSTEMLERİN İLAÇ TAŞIYICI SİSTEM OLARAK KULLANILMA VE TEDAVİ POTANSİYELLERİ

https://orcid.org/0000-0002-1381-3196

Turan Ayhan

Eda

ADIYAMAN ÜNİVERSİTESİ

https://orcid.org/0000-0003-0361-7105

İlbasmış Tamer

Sibel

GAZI UNIVERSITY, FACULTY OF PHARMACY

01 20 2025

49 1 155 170 04 04 2024 09 26 2024

1971

Journal of Faculty of Pharmacy of Ankara University

Objective: Polydopamine (PDA) is the end product of the auto-oxidation and polymerization process of dopamine monomers. PDA has demonstrated significant potential in biomedical fields, particularly due to its photothermal conversion ability, drug binding capacity, versatile adhesion and bioadhesion capabilities, sensitivity to pH changes, and high biocompatibility. Moreover, its superior features have made PDA-based nanoparticles promising for drug delivery systems and treatments. In this review, a comprehensive evaluation of the potential roles of PDA, polymerization mechanisms, and PDA-based nanosystems in the diagnosis and treatment of various diseases is aimed, with a specific emphasis on highlighting the role of PDA in the medical and pharmaceutical fields. Results and Discussion: In literature research, PDA-based nanosystems have been recognized as promising systems for diagnosis and treatment in various fields due to their superior properties. Studies on topics such as particle size, stability, drug release optimization, biodistribution and long-term toxicity analysis of PDA nanoparticles are increasing day by day. It is believed that with the clarification of unresolved and understanding of PDA metabolism and biodegradation mechanisms, these systems can effectively contribute to diagnosis and treatment.

Amaç: Polidopamin (PDA), dopamin monomerinin oto-oksidasyon ve polimerizasyon sürecinin son ürünüdür. PDA, özellikle fototermal dönüşüm yeteneği, ilaç bağlama kapasitesi, çok yönlü adezyon ve biyoadezyon yeteneği, pH değişimine duyarlı olma özelliği ve yüksek biyouyumluluk ile biyomedikal alanlarda büyük potansiyel göstermiştir. Ayrıca taşıdığı üstün özellikler, PDA temelli nanopartikülleri ilaç taşıyıcı sistemler ve tedaviler için potansiyel hale getirmiştir. Bu derlemede, PDA'nın, polimerizasyon mekanizmalarının ve PDA temelli nano-sistemlerin çeşitli hastalıkların tanı ve tedavisindeki potansiyellerinin kapsamlı bir şekilde değerlendirilmesi, özellikle PDA'nın tıp ve eczacılık alanındaki rolünün belirgin hale getirilmesi amaçlanmaktadır.Sonuç ve Tartışma: Yapılan literatür araştırmalarında; üstün özellikleriyle PDA temelli nanosistemlerin, birçok alanda tanı ve tedavi için umut vadedici sistemler olduğu görülmüştür. PDA nanopartiküllerin partikül büyüklüğü, stabilitesi, ilaç salım optimizasyonu, biyodağılım ve uzun vadeli toksisite analizi gibi konularda çalışmalar her geçen gün artmaktadır. PDA'nın metabolizma ve biyodegradasyon mekanizmalarının anlaşılması gibi tam olarak netleştirilememiş bilgilerin aydınlatılmasıyla bu sistemlerin tanı ve tedavide etkin olarak yer alabileceği düşünülmektedir.

İlaç taşıyıcı sistem nanopartiküler sistemler polidopamin tedavi

Drug delivery system nanoparticulate systems polydopamine treatment

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