The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.
Year 2008,
Volume: 37 Issue: 2, 91 - 100, 01.06.2008
Abstract
Oksidatif stres kronik renal yetmezlik gelişiminde ve ateroskleroz gelişiminde rol oynamaktadır. Bu çalışmanın amacı hemodiyaliz hastalarında oksidatif-antioksidatif balansı etkileyebilen faktörleri değerlendirmektir. Çalışmaya 64 hemodiyaliz hastası, kontrol grubu olarak ise 22 sağlıklı kişi dahil edilmiştir. Kronik renal yetmezlikli hastalarda serum süperoksit dismutaz, glutatyon peroksidaz aktiviteleri ve malondialdehid düzeylerindeki değişiklikler ölçüldü ve sağlıklı kontrol grubu ile karşılaştırıldı. Bu parametreler spektrofotometrik method kullanılarak tayin edildi. Hasta grubunun serum süperoksit dismutaz aktivitesi kontrol grubundan daha yüksek bulunmuştur (p<0.001), glutatyon peroksidaz aktivitesi ise daha düşüktür (p<0.001). Kronik renal yetmezlikli hastaların malondialdehid düzeyleri kontrol grubundan daha yüksektir (p<0.01). Kronik renal yetmezlikli hastalarda süperoksit dismutaz aktivitesine yönelik çalışmalarda çelişkili sonuçlar gözlenmektedir. Bu hastalarda artmış süperoksit dismutaz aktivitesini, artmış serbest radikal üretimine bağlı koruyucu bir mekanizma olarak değerlendirebiliriz. Çalışmamız, kronik renal yetmezlikli hastalarda majör risk faktörlerinden biri olarak düşünülen oksidatif stresteki artışı desteklemektedir
Year 2008,
Volume: 37 Issue: 2, 91 - 100, 01.06.2008
Abstract
Oxidative stress is at play in the progression of chronic renal failure (CRF) and in the genesis of atherosclerosis.The aim of the present study was to evaluate the factors that might influence the oxidativeantioxidative balance in patients on hemodialysis. The study group was consisted of 64 hemodialysis patients due to CRF. Twenty-two healthy subjects constituted a control group. We measured changes in serum superoxide dismutase and glutathione peroxidase activity, and malondialdehyde levels in chronic renal failure patients and compared with healthy control groups. Superoxide dismutase and glutathione peroxidase activity, and malondialdehyde levels were assayed with spectrophotometric methods. Superoxide dismutase activity of CRF patients group were higher than those of control group (p<0.001). Glutathione peroxidase activity of CRF patients group were lower than those of control group (p<0.001). Malondialdehyde levels in hemodialysis patients were higher than those of control group (p<0.01). Several studies of SOD activity in chronic renal failure patients have found conflicting results. We propose that the increased SOD activity could be a protective mechanism for the cells due to the hyperproduction of free radicals in chronic renal failure. Decreased serum antioxidant activity in CRF patients on hemodialysis may contribute to the increased oxidative damage and in the development of renal complications. This study indicates the existence and increased production of oxidative stress resulting from hemodialysis and disturbance in antioxidant enzyme system. Our results supports that an increase in oxidative stress may be considered as one of the major risk factors in chronic renal failure patients
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Details
| Other ID | JA58BE25AC |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | June 1, 2008 |
| Submission Date | June 1, 2008 |
| Published in Issue | Year 2008 Volume: 37 Issue: 2 |