CURRENT DRUG TREATMENT IN SJÖGREN’S SYNDROME

Year 2025, Volume: 49 Issue: 1, 171 - 183, 20.01.2025

Aybüke Öztürk Ebru Uzunhisarcıklı

https://doi.org/10.33483/jfpau.1526554

Abstract

Objective: In this review study, it is aimed to focus on the findings and treatment methods obtained to date regarding Sjögren's (Sikka) syndrome. In this context, the available evidence on the epidemiology, clinical findings, diagnostic methods and treatment of Sjögren's syndrome, mostly obtained from observational, open-label and randomized clinical studies, and muscarinic agonists such as Pilocarpine and Sevimelin, antimalarials (Hydroxychloroquine); traditional non-biological disease-modifying antirheumatic drugs (DMARDs) such as Methotrexate, Leflunomide, Azathioprine, Sulfasalazine, Mycophenolic acid and Cyclosporine; and other potent agents are mentioned, including the alkylating agent Cyclophosphamide and the B-cell-targeting anti-CD20 antibody Rituximab.
Result and Discussion: Patients should undergo a comprehensive pre-treatment evaluation to confirm the diagnosis and determine the degree of the disease and benefit from therapeutic lifestyle changes and pharmacological agents accordingly. Patients with moderate to severe involvement generally require systemic medical treatment, including the use of immunosuppressants and biologic agents, depending on the clinical picture, tissues, and organ system affected.

Keywords

Alkylating agent, DMARD, muscarinic agonist, Rituximab

SJÖGREN SENDROMUNDA GÜNCEL İLAÇ TEDAVİSİ

Abstract

Amaç: Bu derleme çalışmasında Sjögren (Sikka) sendromuna ilişkin bugüne kadar elde edilen bulgulara ve tedavi yöntemlerine odaklanılması amaçlanmıştır. Bu bağlamda Sjögren sendromunun epidemiyolojisi, klinik bulguları, tanı yöntemleri ve tedavisine yönelik, çoğunlukla gözlemsel, açık etiketli ve randomize klinik çalışmalardan elde edilen mevcut kanıtlar ile Pilokarpin ve Sevimelin gibi muskarinik agonistler, antimalaryaller (Hidroksiklorokin); Metotreksat, Leflunomid, Azatioprin, Sülfasalazin, Mikofenolik asit ve Siklosporin gibi geleneksel biyolojik olmayan hastalığı modifiye eden antiromatizmal ilaçlar (DMARD'ler); ve aralarında alkilleyici ajan Siklofosfamid ve B hücrelerini hedef alan anti-CD20 antikoru Rituksimab'ın da bulunduğu diğer güçlü ajanlardan bahsedilmiştir.
Sonuç ve Tartışma: Hastalar, tanıyı doğrulamak ve hastalığın derecesini belirlemek için kapsamlı bir tedavi öncesi değerlendirmeye tabi tutulmalı ve buna göre terapötik yaşam tarzı değişiklikleri ile farmakolojik ajanlardan yararlanmalıdır. Orta ve şiddetli tutulumu olan hastalar genellikle klinik tabloya, dokulara ve etkilenen organ sistemine bağlı olarak immünsüpresiflerin ve biyolojik ajanların kullanımı da dahil olmak üzere sistemik tıbbi tedaviye ihtiyaç duymaktadırlar.

Keywords

Alkilleyici ajan, DMARD, muskarinik agonist, Rituksimab

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