To Which Patients Should Intrauterine HCG Injection Be Applied In In Vitro Fertilization?

Year 2018, Volume: 15 Issue: 4, 159 - 163, 01.10.2018

Ali Sami Gürbüz , Necati Özçimen Emel Ebru Özçimen

Abstract

Aim: To investigate the impact of the intrauterine injection of hCG before embryo transfer in in vitro fertilization IVF according to number of transfer.Material And Methods: One hundred and sixty-eight 168 patients were included to the study group; 274 patients were included to the control group. The patients were divided into 2 study and 2 control groups.Group 1: Study group patients in the first and the second IVF cycles. N=126 Group 2: Control group patients in the first and the second IVF cycles. N=189 Group 3: Study group patients in the third or more IVF cycles. N=42 Group 4: Control group patients in the third or more IVF cycles. N=85 Fresh IVF-embryo transfer ET was performed to all patients. Intrauterine hCG injection was performed before ET in the study groups.Results: The pregnancy, clinical pregnancy and implantation rates were significantly increased in the intrauterine hCG injected patients with third or more IVF cycles p= 0.03, p= 0.02, p= 0.02 respectively.Conclusion: The intrauterine hCG injection improved the pregnancy rates in the patient with recurrent IVF failures.

Keywords

Intrauterine hCG, infertility, IVF, recurrent IVF failures, hCG

İntrauterin HCG Enjeksiyonu IVF' te Hangi Hastalara Uygulanmalıdır?

Abstract

Amaç: İn vitro fertilizasyon IVF tedavisinde embryo transferinden önce yapılan intrauterin human chorionic gonadothropin enjeksiyonlarının etkisinin değerlendirilmesi amaçlanmıştır.Gereç ve Yöntemler: Yüz atmış sekiz hasta çalışma grubuna alındı. 274 hasta ise kontrol grubuna dahil edildi. Hasta grupları kendi içinde de ikiye ayrıldı.Grup 1: Birinci ve ikinci IVF denemesi olan çalışma grubu hastaları N:126 Grup 2: Birinci ve ikinci IVF denemesi olan control grubu hastaları N:189 Grup 3: Üç veya daha fazla IVF denemesi olan çalışma grubu hastaları N:42 Grup 4: Üç veya daha fazla IVF denemesi olan control grubu hastaları. N:85 .Tüm hastalara taze embryo transferi ET yapıldı. Çalışma grubuna ET öncesi intrauterine hcg enjeksiyonu uygulandı.Bulgular: Üç veya daha fazla sayıda IVF uygulaması yapılmış hastalarda gebelik, klinik gebelik ve implantasyon oranları intrauterine hCG enjekte edilenlerde belirgin düzeyde yüksek çıkmıştır. p=0,03, p=0,02, p=0,02 sırasıyla Sonuç: Intrauterin hCG enjeksiyonu tekrarlayan IVF başarısızlığı olan hastalarda gebelik oranlarını iyileştirmektedir.

Keywords

Intrauterin hCG, infertilite, tekrarlayan IVF başarısızlığı, hCG

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