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A Biomedical Engineering Approach In Measurement of Term And Preterm Delivery Fetal Membrane Thickness

Year 2016, Volume: 13 Issue: 4, 139 - 142, 01.10.2016

Abstract

Aim: Preterm births are one of the most frequent causes of mortality during or after birth however, its etiology is not fully understood. There are many reasons that cause preterm birth, but their individual effects are unknown. Each reasons have to be observed saperately. Biomechanical features of fetal membranes are so important, because any fe ailure on fetal membranes may cause premature rupture, which causes the release of amniotic fluid initiating pre-term birth. Biomechanical features as stiffness and thickness should be observed to assign relationship between preterm delivery. Aim of the current study is to introduce a new experimental in-vitro thickness measurement system design and evaluate thickness results of fetal membranes.Material and Methods: 24 pieces that are obtained from four fetal membranes, two normal term and two pre-term, were examined with non contact laser displacement sensor and their thickness were discussed.Results: The average thickness of normal term and pre-term were measured as 0,364 ± 0,044mm n=13 and 0,268 ± 0,057mm n=11 , respectively. Differences were statistically significant p=0,002, Mann-Whitney .Conclusion: As a result, the thickness of normal term fetal membranes were found thicker than pre-term fetal membranes with the experimental in-vitro measurement system. However, number of measurements should be increased on feature researchers to evaluate differences better in significant way.

References

  • Alger LS, Pupkin MJ. Etiology of preterm premature rupture of the membranes. Clin Obstet Gynecol. 1986;29:758-70.
  • Micili SC, Valter M, Oflaz H, Ozogul C, Linder P, Fockler N, et al. Optical coherence tomography: a potential tool to predict premature rupture of fetal membranes. Proc Inst Mech Eng H. 2013;227:393-401.
  • Gratacos E, Sanin-Blair J, Lewi L, Toran N, Verbist G, Cabero L, et al. A histological study of fetoscopic membrane defects to document membrane healing. Placenta. 2006;27:452-6.
  • Holanda MR, Melo AN. Comparative clinical study of preterm and full- term newborn neonatal seizures. Arq Neuropsiquiatr. 2006;64:45-50.
  • Joyce EM, Moore JJ, Sacks MS. Biomechanics of the fetal membrane prior to mechanical failure: review and implications. Eur J Obstet Gynecol Reprod Biol. 2009;144:121-7.
  • Moore RM, Mansour JM, Redline RW, Mercer BM, Moore JJ. The physiology of fetal membrane rupture: insight gained from the determination of physical properties. Placenta. 2006;27:1037-51.
  • Faturechi R, Hashemi A, Fatouraee N. Do mechanical properties of human fetal membrane depend on strain rate? J Obstet Gynaecol Res. 2015;41:84-91.
  • Oyen ML, Cook RF, Calvin SE. Mechanical failure of human fetal membrane tissues. J Mater Sci Mater Med. 2004;15:651-8.
  • Lavery JP, Miller CE. The viscoelastic nature of chorioamniotic membranes. Obstet Gynecol. 1977;50:467-72.
  • Lavery JP, Miller CE. Deformation and creep in the human chorioamniotic sac. Am J Obstet Gynecol. 1979;134:366-75.
  • Lavery JP, Miller CE, Knight RD. The effect of labor on the rheologic response of chorioamniotic membranes. Obstet Gynecol. 1982;60:87- 92.
  • Fisk NM, Ronderos-Dumit D, Tannirandorn Y, Nicolini U, Talbert D, Rodeck CH. Normal amniotic pressure throughout gestation. Br J Obstet Gynaecol. 1992;99:18-22.
  • Helmig R, Oxlund H, Petersen LK, Uldbjerg N. Different biomechanical properties of human fetal membranes obtained before and after delivery. Eur J Obstet Gynecol Reprod Biol. 1993;48:183-9.
  • Halaburt JT, Uldbjerg N, Helmig R, Ohlsson K. The concentration of collagen and the collagenolytic activity in the amnion and the chorion. Eur J Obstet Gynecol Reprod Biol. 1989;31:75-82.
  • Jabareen M, Mallik AS, Bilic G, Zisch AH, Mazza E. Relation between mechanical properties and microstructure of human fetal membranes: an attempt towards a quantitative analysis. Eur J Obstet Gynecol Reprod Biol. 2009;144 Suppl 1:S134-41.
  • Oxlund H, Helmig R, Halaburt JT, Uldbjerg N. Biomechanical analysis of human chorioamniotic membranes. Eur J Obstet Gynecol Reprod Biol. 1990;34:247-55.

Erken ve Miadında Doğumda Fetal Zarın Kalınlık Ölçümü: İn-vitro Biyomedikal Mühendislik Yaklaşımı

Year 2016, Volume: 13 Issue: 4, 139 - 142, 01.10.2016

Abstract

Amaç: Erken doğum perinatal hastalık ve ölümlere sebep olabilmektedir fakat etyolojisi henüz çok iyi anlaşılmamıştır. Erken doğuma birçok etken sebep olmakta fakat hangi etkenin ne kadar etkilediği net olarak bilinmemektedir. Her bir etkenin araştırılıp erken doğuma etkileri araştırılmalıdır.Fetal zarın biyomekanik özellikleri önemlidir, çünkü gebelik süresi boyunca zar üzerinde oluşabilecek mekanik hasarlar amniyon sıvısının dışarıya akmasına ve doğum sürecinin erken başlamasına sebep olabilmektedir. Bu sebeple fetal zarın sertlik, mukavemet ve kalınlık özellikleri, erken membran rüptürünün etyolojisini ortaya koymada önemlidir. Bu çalışmanın amacı fetusu saran fetal zarın kalınlığının biyomedikal mühendisliği yaklaşımı ile nasıl ölçülebileceğini tartışmak ve yapılan farklı ölçümleri değerlendirmektir.Gereç ve Yöntemler: Temassız lazer deplasman ölçer ile tasarlanan in-vitro test düzeneğinde iki miad ve iki erken doğuma ait olacak şekilde toplam dört fetal zardan elde edilmiş 24 test numunesi üzerinde kalınlık ölçümleri yapılıp gruplanmıştır.Bulgular: Elde edilen sonuçlara göre miadında doğuma ait ortalama fetal zar kalınlığının 0,364±0,044mm n=13 ve erken doğuma ait ortalama fetal zar kalınlığının 0,268±0,057mm n=11 olduğu gözlemlenmiştir. Aralarındaki fark istatistiksel olarak anlamlıdır p=0,002, Mann-Whitney Test .Sonuç: Sonuç olarak, temassız lazer deplasman ölçer yardımı ile tasarlanan in-vitro test düzeneğinde yapılan ölçümlere göre, miadında doğum yapan kadınların fetal zarı erken doğum yapan kadınlara göre anlamlı olarak kalın bulunmuştur. Fakat ölçüm yapılacak fetal zar sayısının artırılarak ölçümlerin tekrar edilip istatistiksel olarak daha güvenilir sonuçların alınması gerekmektedir.

References

  • Alger LS, Pupkin MJ. Etiology of preterm premature rupture of the membranes. Clin Obstet Gynecol. 1986;29:758-70.
  • Micili SC, Valter M, Oflaz H, Ozogul C, Linder P, Fockler N, et al. Optical coherence tomography: a potential tool to predict premature rupture of fetal membranes. Proc Inst Mech Eng H. 2013;227:393-401.
  • Gratacos E, Sanin-Blair J, Lewi L, Toran N, Verbist G, Cabero L, et al. A histological study of fetoscopic membrane defects to document membrane healing. Placenta. 2006;27:452-6.
  • Holanda MR, Melo AN. Comparative clinical study of preterm and full- term newborn neonatal seizures. Arq Neuropsiquiatr. 2006;64:45-50.
  • Joyce EM, Moore JJ, Sacks MS. Biomechanics of the fetal membrane prior to mechanical failure: review and implications. Eur J Obstet Gynecol Reprod Biol. 2009;144:121-7.
  • Moore RM, Mansour JM, Redline RW, Mercer BM, Moore JJ. The physiology of fetal membrane rupture: insight gained from the determination of physical properties. Placenta. 2006;27:1037-51.
  • Faturechi R, Hashemi A, Fatouraee N. Do mechanical properties of human fetal membrane depend on strain rate? J Obstet Gynaecol Res. 2015;41:84-91.
  • Oyen ML, Cook RF, Calvin SE. Mechanical failure of human fetal membrane tissues. J Mater Sci Mater Med. 2004;15:651-8.
  • Lavery JP, Miller CE. The viscoelastic nature of chorioamniotic membranes. Obstet Gynecol. 1977;50:467-72.
  • Lavery JP, Miller CE. Deformation and creep in the human chorioamniotic sac. Am J Obstet Gynecol. 1979;134:366-75.
  • Lavery JP, Miller CE, Knight RD. The effect of labor on the rheologic response of chorioamniotic membranes. Obstet Gynecol. 1982;60:87- 92.
  • Fisk NM, Ronderos-Dumit D, Tannirandorn Y, Nicolini U, Talbert D, Rodeck CH. Normal amniotic pressure throughout gestation. Br J Obstet Gynaecol. 1992;99:18-22.
  • Helmig R, Oxlund H, Petersen LK, Uldbjerg N. Different biomechanical properties of human fetal membranes obtained before and after delivery. Eur J Obstet Gynecol Reprod Biol. 1993;48:183-9.
  • Halaburt JT, Uldbjerg N, Helmig R, Ohlsson K. The concentration of collagen and the collagenolytic activity in the amnion and the chorion. Eur J Obstet Gynecol Reprod Biol. 1989;31:75-82.
  • Jabareen M, Mallik AS, Bilic G, Zisch AH, Mazza E. Relation between mechanical properties and microstructure of human fetal membranes: an attempt towards a quantitative analysis. Eur J Obstet Gynecol Reprod Biol. 2009;144 Suppl 1:S134-41.
  • Oxlund H, Helmig R, Halaburt JT, Uldbjerg N. Biomechanical analysis of human chorioamniotic membranes. Eur J Obstet Gynecol Reprod Biol. 1990;34:247-55.
There are 16 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Hakan Oflaz This is me

Publication Date October 1, 2016
Published in Issue Year 2016 Volume: 13 Issue: 4

Cite

Vancouver Oflaz H. Erken ve Miadında Doğumda Fetal Zarın Kalınlık Ölçümü: İn-vitro Biyomedikal Mühendislik Yaklaşımı. JGON. 2016;13(4):139-42.