Serum Ca-125, Estradiol And Progesterone Levels In Histopathologically Confirmed Ectopic Pregnancy Cases

Year 2015, Volume: 12 Issue: 4, 140 - 143, 01.07.2015

And Yavuz , Mehmet Özgür Akkurt Gökhan Karakoç Mehmet Muammer Doğan Yakup Yalçın Burak Tatar

Abstract

Aim: To compare the serum, estradiol, progesterone, E2-P ratio and cancer antigen 125 levels between intrauterine pregnancy and ectopic pregnancy, to investigate the probable role of these markers for earlu diagnosis of ectopic pregnancy.Material and Methods: 100 patients who had diagnosis of histopathological confirmed ectopic pregnancy were defined as study group. 100 women with intrauterine, single, 6-8 weeks of gestation were defined as control group. Serum levels of CA-125, E2 and P were compared between groups. Ninety patients underwent laparoscopic surgery for ectopic pregnancy and 10 patients underwent laparatomy. Eighty-nine patients had salpingectomy and 11 of them had salpingostomy.Results: When we compared with control group, serum Ca-125, E2, P levels and E2-P ratio were lower in ectopic pregnancy group. The difference between these two groups were statistically significant. There is no statistically significant difference in E2-P ratios, E2, P and Ca-125 levels when the ectopic pregnancy group were divided into two groups as ruptured and non-ruptured.Conclusion: According to our findings, Ca-125, estradiol, progesterone levels and estradiol-progesterone ratio are useful but not satisfactory markers in the early diagnosis of ectopic pregnancy. Moreover, these parameters cannot be used in the diagnosis of rupture in ectopic pregnancy.

Keywords

CA-125 antigen, pregnancy, ectopic, estradiol, progesterone

Histopatolojik Olarak Ektopik Gebe Olduğu Kanıtlanan Hastalarda Serum Ca-125, Östradiol ve Progesteron Düzeyleri

Abstract

Amaç: Serum östradiol, progesteron, E2-P oranı ve kanser antijen 125 düzeylerinin normal gebelik ve ektopik gebeliği olan hastalarda karşılaştırılarak, bu parametrelerin ektopik gebeliğin erken tanısında muhtemel etkisinin belirlenmesi amaçlanmaktadır.Gereç ve Yöntemler: Çalışma grubuna; ektopik gebelik tanısı ile opere olup histopatolojik olarak tanısı doğrulanan 100 hasta dahil edildi. Kontrol grubunda ise 6-8 haftalar arasında normal intrauterin gebeliği olan 100 kadın çalışmaya dahil edildi. Gruplar kan Ca-125, E2 ve P seviyesi açısından karşılaştırıldı. Çalışma grubundaki 10 hastaya laparatomik yaklaşım, 90 hastaya laparaskopik yaklaşım yapıldı. Ektopik gebeliklerin 30’unda rüptür saptandı. 89 hastaya salpenjektomi yapılırken, 11 hastaya salpingostomi yapıldı.Bulgular: Kontrol grubuyla karşılaştırıldığında, ektopik gebelik grubunda Ca-125, E2, P ve E2-P oranı istatiksel olarak anlamlı düşük bulunmuştur. Ektopik gebelikler kendi içinde değerlendirildiğinde rüptüre olan ve olmayan ektopik gebelerin E2-P oranı, E2, P ve Ca-125 düzeyi arasında istatistiksel olarak anlamlı bir fark bulunamadı.Sonuç: Çalışmamızda değerlendirdiğimiz E2, P, E2-P oranı ve Ca-125 ölçümü ektopik gebelik tanısında faydalı markerler olmakla birlikte ektopik gebeliğin teşhisinde tek başına yetersizdir. Yine bu parametreler ektopik gebeliğin rüptüre olup olmadığının ayrımında yetersizdir.

Keywords

CA-125 antijeni, gebelik, ektopik, östradiol, progesteron

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