j health sci med / jhsm

Journal of Health Sciences and Medicine

2636-8579

MediHealth Academy Yayıncılık

10.32322/jhsm.1077726

Health Care Administration

Sağlık Kurumları Yönetimi

The comparison of treatment with orlistat and orlistat plus metformin in relation to insulin resistance and weight loss

https://orcid.org/0000-0002-0391-7848

Kalan Sarı

Işılay

SBÜ ANTALYA EĞİTİM VE ARAŞTIRMA HASTANESİ

https://orcid.org/0000-0001-6956-2886

Ceylan

Serkan

SBÜ ANTALYA EĞİTİM VE ARAŞTIRMA HASTANESİ

05 30 2022

5 3 755 759 02 23 2022 03 26 2022

2018

Journal of Health Sciences and Medicine

Introduction: Obesity is a growing health problem. Many drugs have been developed to treat obesity. Orlistat is a widely used drug to treat this disease. Metformin is an antidiabetic drug. Clinicians often prescribe it to treat insulin resistance and achieve weight loss. Our research aims to compare the effects of orlistat alone and its combination with metformin on weight loss and insulin resistance.Material and Method: This retrospective study was conducted by scanning the data of patients who presented to Antalya Training and Research Hospital Endocrinology, and General Surgery Clinics between 2016 and 2021. 42 morbidly obese patients who met inclusion and exclusion criteria and were prescribed orlistat plus metformin (group 1, n: 28) or orlistat alone (group 2, n: 14) along with a low-calorie diet for three months and were taking it regularly were included. Subsequently, weight, body mass index, fasting blood glucose, fasting insulin, and HOMA-IR (homeostasis model assessment for insulin resistance) were recorded and analyzed at baseline and after three months of taking the medications.Results: After 3 months of treatment, significant weight loss was achieved in both groups compared to baseline weight (p=0.001 group 1, p=0.003 group 2). HOMA-IR values decreased significantly in both groups (p=0.001 group 1, p=0.01 group 2). Both groups lost the same amount of weight after three months (p=0.06).Conclusion: In morbidly obese patients without prediabetes or diabetes, the addition of metformin to orlistat therapy did not add benefits in terms of weight loss or insulin resistance.

orlistat obesity metformin insulin resistance

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