j health sci med / jhsm Journal of Health Sciences and Medicine 2636-8579 MediHealth Academy Yayıncılık 10.32322/jhsm.1092191 Health Care Administration Sağlık Kurumları Yönetimi The role of red cell distribution width in predicting the prognosis of patients with breast cancer https://orcid.org/0000-0002-3672-5738 Özdemir Dursun Burak SBU Samsun City Training and Research Hospital https://orcid.org/0000-0003-0380-9190 Karayiğit Ahmet SBU Adana City Training and Research Hospital https://orcid.org/0000-0002-4031-2557 Dizen Hayrettin Acibadem Eskisehir Hospital https://orcid.org/0000-0003-2538-7961 Ünal Bülent ISTANBUL AYDIN UNIVERSITY, SCHOOL OF MEDICINE 07 20 2022 5 4 1170 1175 03 29 2022 06 28 2022 Copyright © 2018, Journal of Health Sciences and Medicine 2018 Journal of Health Sciences and Medicine

Objective: In this study, we aimed to assess the relationship between preoperative red cell distribution width (RDW) and the clinicopathological stage and prognosis of disease in patients operated for invasive epithelial breast cancer (BC).Material and Method: This retrospective cross-sectional study was conducted between January 2010 and January 2015 at a tertiary hospital in Turkey. A total of 280 patients who underwent surgery for histologically diagnosed invasive epithelial BC were included in the study. Results: The mean age of the patients was 53.31±12.58 years. The median follow-up time was 83 (IQR: 56.5–102) months. According to the results we found, there was a statistically significant positive correlation between progesterone receptor (PR) negativity and RDW values (p=0.015). In addition, the RDW values of patients with perineural invasion (PNI) were found to be significantly higher than those without (p=0.036). Conclusion: When the results of our study are evaluated together with prior reports, it can be said that higher preoperative RDW is associated with poor prognosis. When RDW is evaluated together with other possible prognostic factors, such as PNI and PR status, it has the potential to be a new, easily applicable and accurate marker to assess prognosis in patients with invasive epithelial BC.

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