j health sci med / jhsm

Journal of Health Sciences and Medicine

2636-8579

MediHealth Academy Yayıncılık

10.32322/jhsm.1330040

Gynecologic Oncology Surgery

Jinekolojik Onkoloji Cerrahisi

Ultrasonic shear-wave elastography: a novel method for assessing the tumor grade in endometrial cancer: a prospective study

https://orcid.org/0000-0001-5726-0223

Destegül

Emre

SAĞLIK BİLİMLERİ ÜNİVERSİTESİ ADANA ŞEHİR EĞİTİM VE ARAŞTIRMA HASTANESİ

https://orcid.org/0000-0002-7286-5535

Çakır Peköz

Burçak

SAĞLIM BİLİMLERİ ÜNİVERSİTESİ ADANA ŞEHİR EĞİTİM VE ARAŞTIRMA HASTANESİ

https://orcid.org/0000-0001-8607-6628

Seyfettinoğlu

Sevtap

SAĞLIK BİLİMLERİ ÜNİVERSİTESİ ADANA ŞEHİR EĞİTİM VE ARAŞTIRMA HASTANESİ

https://orcid.org/0000-0002-6454-6470

Baş

Sevda

SAĞLIK BİLİMLERİ ÜNİVERSİTESİ ADANA ŞEHİR EĞİTİM VE ARAŞTIRMA HASTANESİ

https://orcid.org/0000-0001-6849-2193

Adıgüzel

Fikriye Işıl

SAĞLIK BİLİMLERİ ÜNİVERSİTESİ ADANA ŞEHİR EĞİTİM VE ARAŞTIRMA HASTANESİ

https://orcid.org/0000-0002-8145-9053

Narin

Mehmet

SAĞLIK BİLİMLERİ ÜNİVERSİTESİ ADANA ŞEHİR EĞİTİM VR ARAŞTIRMA HASTANESİ

09 28 2023

6 5 987 992 07 19 2023 08 30 2023

2018

Journal of Health Sciences and Medicine

Aims: To evaluate the diagnostic performance of the real time shear-wave elastography in patients with endometrial cancer in terms of tumor grade and myometrial invasion depth preoperatively.Methods: In this prospective observational study, forty-eight women who were diagnosed with endometrioid type endometrium cancer in our gynecologic oncology clinic of a tertiary hospital between September 2020-January 2021 in Turkey. All patients underwent an ultrasonographic shear-wave measurements. Mean shear-wave values were measured from the tumor itself. Mean elasticity values were assessed in terms of tumor grade and myometrial invasion depth.Results: The median [%25-%75] shearwave value of the participants was 29.45kPa (5.02-167.21). Shear-wave value for grade 3 endometrial cancer showed a statistically significant difference compared to grade 1 and 2 shear-wave values (p0.05). ROC curve analysis showed significant results to determine the myometrial invasion depth and grade 3 endometrial cancer with the mean shear-wave cut-off values of 28.29 kPa and 57 kPa respectively (p

Endometrial cancer Shear-wave elastography shear-wave tumor grade grade 3 endometrial cancer

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7-34. doi:10.3322/caac.21551

Vitale SG, Capriglione S, Zito G, et al. Management of endometrial, ovarian and cervical cancer in the elderly: current approach to a challenging condition. Arch Gynecol Obstet. 2019;299(2):299-315. doi:10.1007/s00404-018-5006-z

Health UNIo. National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch. Surveillance, Epidemiology, and End Results (SEER). Program Research Data (1973-2008). 2015.

Sorosky JI. Endometrial cancer. Obstet Gynecol. 2012;120(2 Pt 1):383-397. doi:10.1097/AOG.0b013e3182605bf1

Krouskop TA, Dougherty DR, Vinson FS. A pulsed Doppler ultrasonic system for making noninvasive measurements of the mechanical properties of soft tissue. J Rehabil Res Dev. 1987;24(2):1-8.

Lerner RM, Huang SR, Parker KJ. "Sonoelasticity" images derived from ultrasound signals in mechanically vibrated tissues. Ultrasound Med Biol. 1990;16(3):231-239. doi:10.1016/0301-5629(90)90002-t

Emelianov SY, Lubinski MA, Weitzel WF, Wiggins RC, Skovoroda AR, O'Donnell M. Elasticity imaging for early detection of renal pathology. Ultrasound Med Biol. 1995;21(7):871-883. doi:10.1016/0301-5629(94)00146-5

Ophir J, Cespedes I, Ponnekanti H, Yazdi Y, Li X.eElastography: a quantitative method for imaging the elasticity of biological tissues. Ultrason Imaging. 1991;13(2):111-134. doi:10.1177/ 016173469101300201

Shiina T, Nightingale KR, Palmeri ML, et al. WFUMB guidelines and recommendations for clinical use of ultrasound elastography: Part 1: basic principles and terminology. Ultrasound Med Biol. 2015;41(5):1126-1147. doi:10.1016/j.ultrasmedbio.2015.03.009

Liu Z, Jing H, Han X, et al. Shear wave elastography combined with the thyroid imaging reporting and data system for malignancy risk stratification in thyroid nodules. Oncotarget. 2017;8(26):43406-43416. doi:10.18632/oncotarget.15018

Lee HY, Lee JH, Shin JH, et al. Shear wave elastography using ultrasound: effects of anisotropy and stretch stress on a tissue phantom and in vivo reactive lymph nodes in the neck. Ultrasonography. 2017;36(1):25-32. doi:10.14366/usg.16003

Ariji Y, Nakayama M, Nishiyama W, Nozawa M, Ariji E. Shear-wave sonoelastography for assessing masseter muscle hardness in comparison with strain sonoelastography: study with phantoms and healthy volunteers. Dentomaxillofac Radiol. 2016;45(2):20150251. doi:10.1259/dmfr.20150251

Chang JM, Won JK, Lee KB, Park IA, Yi A, Moon WK. Comparison of shear-wave and strain ultrasound elastography in the differentiation of benign and malignant breast lesions. AJR Am J Roentgenol. 2013;201(2):347-356. doi:10.2214/AJR.12.10416

Cong Y, Fan Z, Dai Y, Zhang Z, Yan K. Application value of shear wave elastography in the evaluation of tumor downstaging for locally advanced rectal cancer after neoadjuvant chemoradiotherapy. J Ultrasound Med. 2021;40(1):81-89. doi:10.1002/jum.15378

Zhao HX, Du YY, Guo YJ, et al. Application value of real-time shear wave elastography in diagnosing the depth of infiltrating muscular layer of endometrial cancer. J Ultrasound Med. 2021;40(9):1851-1861. doi:10.1002/jum.15568

Liu C, Li TT, Hu Z, et al. Transvaginal real-time shear wave elastography in the diagnosis of cervical disease. J Ultrasound Med. 2019;38(12):3173-3181. doi:10.1002/jum.15018

Barr RG, Ferraioli G, Palmeri ML, et al. Elastography assessment of liver fibrosis: society of radiologists in ultrasound consensus conference statement. Radiology. 2015;276(3):845-861. doi:10.1148/radiol.2015150619

Bojunga J, Herrmann E, Meyer G, Weber S, Zeuzem S, Friedrich-Rust M. Real-time elastography for the differentiation of benign and malignant thyroid nodules: a meta-analysis. Thyroid. 2010;20(10):1145-1150. doi:10.1089/thy.2010.0079

Bakay OA, Golovko TS. Use of elastography for cervical cancer diagnostics. Exp Oncol. 2015;37(2):139-145.

Bian J, Li J, Liu Y. Diagnostic accuracy of shear wave elastography for endometrial cancer: A meta-analysis. Medicine (Baltimore). 2023;102(4):e32700. doi:10.1097/MD.0000000000032700

Murali R, Davidson B, Fadare O, et al. High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations. Int J Gynecol Pathol. 2019;38 Suppl 1(Iss 1 Suppl 1):S40-S63. doi:10.1097/PGP.0000000000000491

Koyama T, Tamai K, Togashi K. Staging of carcinoma of the uterine cervix and endometrium. Eur Radiol. 2007;17(8):2009-2019. doi:10.1007/s00330-006-0555-0

Fukuhara T, Matsuda E, Endo Y, et al. Correlation between quantitative shear wave elastography and pathologic structures of thyroid lesions. Ultrasound Med Biol. 2015;41(9):2326-2332. doi:10.1016/j.ultrasmedbio.2015.05.001

Concin N, Matias-Guiu X, Vergote I, et al. ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma. Int J Gynecol Cancer. 2021;31(1):12-39. doi:10.1136/ijgc-2020-002230

Fujimoto T, Nanjyo H, Fukuda J, et al. Endometrioid uterine cancer: histopathological risk factors of local and distant recurrence. Gynecol Oncol. 2009;112(2):342-347. doi:10.1016/j.ygyno.2008.10.019

Grigsby PW, Perez CA, Kuten A, et al. Clinical stage I endometrial cancer: prognostic factors for local control and distant metastasis and implications of the new FIGO surgical staging system. Int J Radiat Oncol Biol Phys. 1992;22(5):905-911. doi:10.1016/0360-3016(92)90786-h

Creutzberg CL, van Putten WL, Warlam-Rodenhuis CC, et al. Outcome of high-risk stage IC, grade 3, compared with stage I endometrial carcinoma patients: the postoperative radiation therapy in endometrial carcinoma Trial. J Clin Oncol. Apr 1 2004;22(7):1234-1241. doi:10.1200/JCO.2004.08.159

Abu-Rustum NR, Yashar CM, Bradley K, et al. NCCN Guidelines (R) Insights: uterine neoplasms, version 3.2021. J Natl Compr Canc Netw. 2021;19(8):888-895. doi:10.6004/jnccn.2021.0038

Gungorduk K, Muallem J, Asicioglu O, et al. Survival outcomes of women with grade 3 endometrioid endometrial cancer: the impact of adjuvant treatment strategies. Arch Gynecol Obstet. 2022;305(3):671-681. doi:10.1007/s00404-021-06187-4

Baek MH, Park YR, Suh DS, et al. Reliability of tumour grade 1 and endometrioid cell type on preoperative endometrial biopsy. J Obstet Gynaecol. 2015;35(1):79-81. doi:10.3109/01443615.2014.935723

Visser NCM, Reijnen C, Massuger L, Nagtegaal ID, Bulten J, Pijnenborg JMA. Accuracy of endometrial sampling in endometrial carcinoma: a systematic review and meta-analysis. Obstet Gynecol. 2017;130(4):803-813. doi:10.1097/AOG.0000000000002261

Alcazar JL, Gaston B, Navarro B, Salas R, Aranda J, Guerriero S. Transvaginal ultrasound versus magnetic resonance imaging for preoperative assessment of myometrial infiltration in patients with endometrial cancer: a systematic review and meta-analysis. J Gynecol Oncol. 2017;28(6):e86. doi:10.3802/jgo.2017.28.e86

Shao J, Shen Y, Lu J, Wang J. Ultrasound scoring in combination with ultrasound elastography for differentiating benign and malignant thyroid nodules. Clin Endocrinol (Oxf). 2015;83(2):254-260. doi:10.1111/cen.12589

Du YY, Yan XJ, Guo YJ, et al. Transvaginal real-time shear wave elastography in the diagnosis of endometrial lesions. Int J Gen Med. 2021;14:2849-2856. doi:10.2147/IJGM.S312292

Hohn AK, Brambs CE, Hiller GGR, May D, Schmoeckel E, Horn LC. 2020 WHO classification of female genital tumors. Geburtshilfe Frauenheilkd. 2021;81(10):1145-1153. doi:10.1055/a-1545-4279