j health sci med / jhsm

Journal of Health Sciences and Medicine

2636-8579

MediHealth Academy Yayıncılık

10.32322/jhsm.1446058

Gastroenterology and Hepatology

Gastroenteroloji ve Hepatoloji

Frequency of seronegative cases in autoimmune hepatitis and their association with the systemic immune inflammation index

https://orcid.org/0000-0003-0486-1767

Mutlu Bilgiç

Nermin

SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL ÜMRANİYE SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, İÇ HASTALIKLARI ANABİLİM DALI, GASTROENTEROLOJİ BİLİM DALI

03 25 2024

7 2 230 235 03 02 2024 03 24 2024

2018

Journal of Health Sciences and Medicine

Aims: It is suggested that a deficiency in B cells plays a role in pathogenesis of seronegative autoimmune hepatitis (snAIH). The lack of B cells leads to notable changes in the variety of leukocyte types within the bloodstream. This study aimed to determine the frequency of snAIH in patients with autoimmune hepatitis, as well as to explore the relationship between snAIH and leukocyte-based inflammatory indices.Methods: In this retrospective study, 57 patients newly diagnosed with autoimmune hepatitis were included. According to clinical and pathological findings, patients were classified into seropositive autoimmune hepatitis (spAIH) and snAIH groups. The inflammation indices included the platelet to lymphocyte ratio (PLR), the neutrophil to lymphocyte ratio (NLR), and the systemic immune-inflammation index (SII).Results: The frequency of snAIH was 26.3%. The snAIH group exhibited higher NLR (3.0 vs. 1.5, p

Autoimmune hepatitis Seronegative inflammation index

232416878

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