j health sci med / jhsm Journal of Health Sciences and Medicine 2636-8579 MediHealth Academy Yayıncılık 10.32322/jhsm.1625339 Pediatric Cardiology Paediatrics (Other) Çocuk Kardiyolojisi Çocuk Sağlığı ve Hastalıkları (Diğer) COVID-19 pnömonisi olan çocuklarda Hidroksiklorokin ve azitromisin beraber kullanımı kardiyak ritim bozukluklarına neden olur mu? Can hydroxychloroquine and azithromycin combination cause cardiac rhythm disturbances in children with COVID-19 pneumonia? https://orcid.org/0000-0001-6344-7035 Geçkalan Damla Bakırçay Üniversitesi, Çiğli Eğitim ve Araştırma Hastanesi https://orcid.org/0000-0002-2775-166X Özdemir Rahmi İZMİR KATİP ÇELEBİ ÜNİVERSİTESİ https://orcid.org/0000-0003-1724-9833 Yılmaz Yasin KUTAHYA HEALTH SCIENCES UNIVERSITY https://orcid.org/0000-0002-8065-7082 Çelik Cemile Hilal KUTAHYA HEALTH SCIENCES UNIVERSITY https://orcid.org/0000-0002-0349-5112 Demir Batuhan Berk KUTAHYA HEALTH SCIENCES UNIVERSITY https://orcid.org/0000-0002-1078-8730 Tunç Yeşim KUTAHYA HEALTH SCIENCES UNIVERSITY 03 21 2025 8 2 308 312 01 22 2025 02 25 2025 Copyright © 2018, Journal of Health Sciences and Medicine 2018 Journal of Health Sciences and Medicine

GirişCOVID-19 pandemisinin başlangıcında; hidroksiklorokin ve azitromisin tedavisi almanın hastalarda koronavirüs viral taşıyıcılığını azalttığı gösterilmiştir. Bu çalışmada, hidroksiklorokin ve azitromisin ile kombine tedavi alan COVID-19 pnömonili çocuk hastalarda elektrokardiyografi [EKG] anormalliklerini değerlendirmeyi amaçladık.YöntemlerBu çalışmada; Haziran 2020 - Kasım 2020 tarihleri arasında Sağlık Bilimleri Üniversitesi'nde hidroksiklorokin ve azitromisin ile tedavi edilen COVID-19 pnömonili 24 çocuğun EKG ve laboratuvar parametreleri retrospektif olarak analiz edilmiştir. P dalgası dispersiyonu [PWd], QT aralığı [QT], QT dispersiyonu [QTd], QTc aralığı [QTc], QTc dispersiyonu [QTcd], Tpeak-Tend aralığı [Tp-e], Tp-e dispersiyonu [Tp-ed], Tp-e/QT, Tp-Te/QTc oranları 12 derivasyonlu EKG ile değerlendirildi. EKG parametreleri ve QTc aralığı tedaviden önce ve sonra [5 gün] karşılaştırıldı.SonuçOrtalama yaş 13 ± 4,5 yıldı ve %62,5'i kızdı. Medyan hastanede yatış süresi 6 gündü. Tedavi öncesi ve sonrası PWd, QT ve QTc intervali, QTd, QTcd, Tp-e intervali, Tp-e dispersiyonu, Tp-e/QT, Tp-e/QTd ölçümleri ve oranları arasında istatistiksel olarak anlamlı bir fark yoktu [p>0.05]. Tedavi öncesi ve sonrasında sadece kalp hızındaki azalma istatistiksel olarak anlamlı bulunmuştur [p

Aims: At the beginning of the COVID-19 pandemic; it has been shown that receiving hydroxychloroquine and azithromycin treatment decrease viral carriage of coronavirus in patients. In this study, we aimed to evaluate electrocardiography (ECG) abnormalities in pediatric patients with COVID-19 pneumonia receiving combined therapy with hydroxychloroquine and azithromycin.Methods: In this study; ECG and laboratory parameters of 24 children with COVID-19 pneumonia who were treated with hydroxychloroquine and azithromycin at Health Sciences University between June 2020 and November 2020 were analyzed retrospectively. P wave dispersion (PWd), QT interval (QT), QT dispersion (QTd), QTc interval (QTc), QTc dispersion (QTcd), Tpeak-Tend interval (Tp-e), Tp-e dispersion (Tp-ed), Tp-e/QT, Tp-Te/QTc ratios were evaluated with 12 lead ECG. ECG parameters and QTc interval were compared before and after (5 days) the treatment.Results: The mean age was 13±4.5 years and 62.5% were female. Median hospitalization length was 6 days. There was no statistically significant difference between the PWd, QT and QTc interval, QTd, QTcd, Tp-e interval, Tp-e dispersion, Tp-e/QT, Tp-e/QTd measurements and ratios of the before and after treatment. A significant difference was found for the decrease in hearth rate in regard to the measurement before and after the treatment. Conclusion: In our study, there were no rhythm problems which were observed on ECG in pediatric patients receiving hydroxychloroquine and azithromycin combination therapy for COVID-19 pneumonia. We also found that laboratory parameters were not specific for COVID-19 pneumonia in children.

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