j health sci med / jhsm Journal of Health Sciences and Medicine 2636-8579 MediHealth Academy Yayıncılık 10.32322/jhsm.1734344 Obstetrics and Gynaecology Kadın Hastalıkları ve Doğum Bakteriyel vajinozis tedavisinde intravajinal gaz ozon tedavisinin etkinliği ve güvenliği Efficacy and safety of intravaginal gas ozone therapy in the treatment of bacterial vaginosis https://orcid.org/0000-0003-1803-106X Ağlamış Savaş Özgür DR Özgür Ağlamış Clinic https://orcid.org/0000-0002-7017-8854 Yılmaz Ergani Seval 4 Department of Perinatology, Etlik City Hospital, Ankara, Turkey https://orcid.org/0000-0003-4004-8167 Adeviye Şahin Eda Dr Eda Sahin private clinic Şahin Hanifi İstanbul Health and Technology University, https://orcid.org/0000-0003-1616-9735 Şahin Turan Dr ilhan Varank training research hospital 09 16 2025 8 5 811 817 07 04 2025 08 04 2025 Copyright © 2018, Journal of Health Sciences and Medicine 2018 Journal of Health Sciences and Medicine

ÖzetAmaçlar: Bu çalışmanın amacı, bakteriyel vajinozis (BV) tedavisinde intravajinal gaz ozon tekniğimizle ilgili deneyimlerimizi ve sonuçlarımızı retrospektif veri analiziyle paylaşmaktır.Yöntemler: Salutem plus marka tıbbi ozon cihazı, 60 gama 200 cc gaz ozon, Amsel kriterlerine göre BV tanısı konulan 102 hastaya nazogastrik kateter yardımıyla 50 cc'lik şırıngalarla intravajinal olarak uygulandı. İşlem öncesi ve sonrası hemogram parametreleri kontrol edilen hastalar, tekrarlama açısından 1., 3., 6., 9. ve 12. ay klinik kontrollerine çağrıldı ve bu hastaların muayene bulguları ve dijital verileri tedavi, komplikasyonlar ve tekrarlama açısından retrospektif olarak analiz edildi.Sonuçlar: Yaşamı tehdit eden herhangi bir komplikasyonla karşılaşılmadı. Minör yan etkiler gözlendi ve herhangi bir tedaviye gerek kalmadan kısa sürede kendiliğinden düzeldi. Tekrarlama oranlarının klasik rejim tedavilerine göre daha düşük olduğu görüldü. Ek olarak, 1 yıllık takipte en fazla 2 tekrar gözlendi.Sonuçlar: Çalışmamız bakteriyel vajinozis tedavisinde intravajinal gaz ozon tedavisinin tedavisi, tekrarı ve komplikasyonlarının değerlendirilmesi açısından literatürdeki ilk örnektir. Güvenli bir tedavi şekli olarak kabul edilen intravajinal gaz ozon tedavisinin gelecekte daha da yaygınlaşacağını ve uygulama sayısının ve sıklığının daha da artacağını düşünüyoruz. Verilerimizi doğrulamak için daha fazla sayıda hasta ile daha fazla araştırma yapılmalıdır.

Aims: The aim of this study is to share our experiences and results with our intravaginal gas ozone technique in the treatment of bacterial vaginosis (BV) by retrospective data analysis. Methods: Salutem plus brand medical ozone device, 60 gamma 200 cc gas ozone was administered intravaginally through 50 cc syringes with the help of a nasogastric catheter to 102 patients diagnosed with BV using Amsel criteria. Patients whose hemogram parameters were checked before and after the procedure were called for 1st, 3rd, 6th, 9th and 12th month clinical controls in terms of recurrence, and the examination findings and digital data of these patients were analyzed retrospectively in terms of treatment, complications and recurrence. Results: No life-threatening complications were encountered. Minor adverse effects were observed and resolved spontaneously in a short time without the need for any treatment. Recurrence rates were observed to be lower than in classical regimen treatments. Additionally, no more than 2 recurrences were observed during 1-year follow-up. Conclusion: Our study is the first example of the literature in terms of evaluation of treatment, recurrence and complications of intravaginal gas ozone therapy in the treatment of bacterial vaginosis. These finding suggest that intravaginal gas ozone therapy, which is considered a safe form of treatment, will become more widespread in the future and the number and frequency of its application will increase even more. Further investigation with a larger number of patients should be conducted to confirm our data.

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