Diagnostic and prognostic value of the ratio of mean platelet volume to platelet count in acute mesenteric ischemia

Year 2022, , 682 - 688, 15.03.2022

Murat Bulut Özkan , Ramazan Topcu , Fatih Şahin , Murat Baki Yıldırım

https://doi.org/10.32322/jhsm.1076082

Abstract

Introduction: Acute mesenteric ischemia (AMI) is a condition in which there is a sudden cessation of blood supply to a particular intestinal segment and consequent cellular damage. Although it has a low incidence of approximately 0.09-0.2% of all emergency surgery admissions, AMI is a severe condition that can cause high early mortality. A direct relationship between an increased mean platelet volume (MPV) and acute thrombotic events has been shown in recent years. we aimed to find out whether the diagnosis of mesenteric ischemia and the amount of bowel segment affected by ischemia will guide clinicians preoperatively with these markers
Material and Method: A total of 57 cases with bowel resection due to mesenteric ischemia were included in the study. The gender, age, serum platelet (PLT), MPV, white blood cell count (WBC), neutrophil count (NEU), lymphocyte count (LYM), Albumin, CRP, neutrophil-lymphocyte ratio (NLR), MPV/Platelet Count, and CRP-albumin ratio (CAR) levels at the time of admission, operation time, length of resected bowel segment, length of hospital stay, presence of necrosis and perforation from pathology reports, and length of bowel segment leading to necrosis were scanned.
Results: A moderate (moderate) negative correlation was found between the length of resected bowel segment and PLT (P<0.001; r=-0.685). A moderate positive significant correlation was found between resection length and MPV (P<0.001; r=0.565). A high significant positive correlation was found between resection length and MPV/PC (P<0.001; r=0.857). PLT, WBC and MPV/PC values were statistically different between the perforated group and no-perforation group (p=0.009, p=0.024, p=0.010). WBC and MPV/PC values were significantly higher in the perforated group.
Conclusion: MPV/PC and PLT value at hospital admission is a reliable and simple predictive factor in determining perforation and the amount of bowel segment affected in patients with acute mesenteric ischemia.

Keywords

acute mesenteric ischemia, bowel necrosis, mean platelet volume, platelet indices

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