Association of ABO blood groups with histopathological severity and inflammatory markers in acute appendicitis

Orhan Aslan; Mustafa Şahin; Ramazan Topcu; Mahmut Arif Yüksek; İsmail Sezikli; Aşkın Kadir Perçem; Havva Hande Keser Şahin; Bayram Yılmaz; Emin Rençber

doi:10.32322/jhsm.1878165

Association of ABO blood groups with histopathological severity and inflammatory markers in acute appendicitis

Abstract

Aims: Acute appendicitis (AA) is a common surgical emergency with a heterogeneous clinical and pathological spectrum. Given their established roles in immune modulation, inflammation, and host-pathogen interactions, ABO blood group antigens have been investigated in various infectious and inflammatory diseases. In this study, we aimed to investigate the association between blood groups and the clinical course of acute appendicitis. Methods: This retrospective study data from patients who underwent appendectomy at our center were analyzed. Patients were classified into normal (n=42), uncomplicated (n=970), and complicated (n=213) appendicitis groups based on histopathological findings. Demographic data, ABO blood groups, histopathological findings, preoperative laboratory parameters, and length of hospital stay were evaluated and statistical analyses were performed. Results: No significant differences were observed in ABO blood group distribution among histopathological subgroups (p>0.05). In multivariate analysis, age and C-reactive protein remained independent predictors of complicated appendicitis (p<0.001). Although a lower proportion of blood group O was observed in complicated cases, this trend did not reach statistical significance. Conclusion: ABO blood groups do not appear to be independently associated with severity of acute appendicitis. Future large-scale, multicenter prospective studies incorporating molecular and microbiota-based analyses are warranted to better elucidate individual risk profiles and improve prognostic accuracy in acute appendicitis.

Keywords

References

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Details

Primary Language

English

Subjects

General Surgery

Journal Section

Research Article

Authors

Orhan Aslan
0000-0002-1982-0792
Türkiye

Mustafa Şahin ^*
0000-0001-6073-563X
Türkiye

Ramazan Topcu
0000-0001-6214-4868
Türkiye

Mahmut Arif Yüksek
0000-0002-8323-7390
Türkiye

İsmail Sezikli
0000-0002-6801-1465
Türkiye

Aşkın Kadir Perçem
0000-0002-6726-2422
Türkiye

Havva Hande Keser Şahin
0000-0003-1827-1039
Türkiye

Bayram Yılmaz
0000-0002-1737-9446
Türkiye

Emin Rençber
0000-0002-6482-2551
Türkiye

Publication Date

May 19, 2026

Submission Date

January 30, 2026

Acceptance Date

March 26, 2026

Published in Issue

Year 2026 Volume: 9 Number: 3

DOI

https://doi.org/10.32322/jhsm.1878165

IZ

https://izlik.org/JA25KN72BY

Cite

RIS / Bibtex

APA

Aslan, O., Şahin, M., Topcu, R., Yüksek, M. A., Sezikli, İ., Perçem, A. K., Keser Şahin, H. H., Yılmaz, B., & Rençber, E. (2026). Association of ABO blood groups with histopathological severity and inflammatory markers in acute appendicitis. Journal of Health Sciences and Medicine, 9(3), 658-663. https://doi.org/10.32322/jhsm.1878165

AMA

1.Aslan O, Şahin M, Topcu R, et al. Association of ABO blood groups with histopathological severity and inflammatory markers in acute appendicitis. J Health Sci Med / JHSM. 2026;9(3):658-663. doi:10.32322/jhsm.1878165

Chicago

Aslan, Orhan, Mustafa Şahin, Ramazan Topcu, et al. 2026. “Association of ABO Blood Groups With Histopathological Severity and Inflammatory Markers in Acute Appendicitis”. Journal of Health Sciences and Medicine 9 (3): 658-63. https://doi.org/10.32322/jhsm.1878165.

EndNote

Aslan O, Şahin M, Topcu R, Yüksek MA, Sezikli İ, Perçem AK, Keser Şahin HH, Yılmaz B, Rençber E (May 1, 2026) Association of ABO blood groups with histopathological severity and inflammatory markers in acute appendicitis. Journal of Health Sciences and Medicine 9 3 658–663.

IEEE

[1]O. Aslan et al., “Association of ABO blood groups with histopathological severity and inflammatory markers in acute appendicitis”, J Health Sci Med / JHSM, vol. 9, no. 3, pp. 658–663, May 2026, doi: 10.32322/jhsm.1878165.

ISNAD

Aslan, Orhan - Şahin, Mustafa - Topcu, Ramazan - Yüksek, Mahmut Arif - Sezikli, İsmail - Perçem, Aşkın Kadir - Keser Şahin, Havva Hande - Yılmaz, Bayram - Rençber, Emin. “Association of ABO Blood Groups With Histopathological Severity and Inflammatory Markers in Acute Appendicitis”. Journal of Health Sciences and Medicine 9/3 (May 1, 2026): 658-663. https://doi.org/10.32322/jhsm.1878165.

JAMA

1.Aslan O, Şahin M, Topcu R, Yüksek MA, Sezikli İ, Perçem AK, Keser Şahin HH, Yılmaz B, Rençber E. Association of ABO blood groups with histopathological severity and inflammatory markers in acute appendicitis. J Health Sci Med / JHSM. 2026;9:658–663.

MLA

Aslan, Orhan, et al. “Association of ABO Blood Groups With Histopathological Severity and Inflammatory Markers in Acute Appendicitis”. Journal of Health Sciences and Medicine, vol. 9, no. 3, May 2026, pp. 658-63, doi:10.32322/jhsm.1878165.

Vancouver

1.Orhan Aslan, Mustafa Şahin, Ramazan Topcu, Mahmut Arif Yüksek, İsmail Sezikli, Aşkın Kadir Perçem, Havva Hande Keser Şahin, Bayram Yılmaz, Emin Rençber. Association of ABO blood groups with histopathological severity and inflammatory markers in acute appendicitis. J Health Sci Med / JHSM. 2026 May 1;9(3):658-63. doi:10.32322/jhsm.1878165