Serum levels of ischemic modified albumin (IMA) and prolidase in migraine subjects

Year 2020, Volume: 3 Issue: 1, 31 - 35, 15.01.2020

Bahar Say Nermin Dindar Badem Ufuk Ergun

https://doi.org/10.32322/jhsm.638466

Abstract

Objective: Migraine is one of the most common neurological diseases with headache
attacks. Although its pathophysiology is still unclear, it is thought to be
multifactorial. Oxidative stress is one of the topics discussed in the
pathophysiology of migraine. The aim of this study was to investigate IMA and prolidase
levels, which are oxidative stress markers in migraine.

Material and Method: In this study, 35
migraine and 35 healthy controls were included. Serum IMA and prolidase levels
were measured in serum obtained after centrifugation from venous blood samples
by ELISA. Prolidase and IMA in migraine patients were compared with the control
group.

Results: The mean age was 40.06±11.14 years in migraine (34 female, 1 male) and
34.31±8.26 in controls (31 female, 4 male). There was no significant difference
between the groups in terms of age and gender (p=0.08, p=0.29). Interictal IMA
and prolidase levels of migraine subjects were significantly higher than the
control group (p=0.02, p<0.001). Prolidase was significantly higher in the attack period
than the control group (p<0.001), but there was no significant difference in
IMA levels (p=0.34). Prolidase and IMA levels during the attack were higher
than interictal period in migraine but there was no significant difference  (p>0.05).

Conclusion: Prolidase and IMA may be an indicator of
oxidative stress in migraine patients. Prolidase, one of the oxidative stress
indicators, also correlates with the frequency of attacks in migraine. It
is thought that these markers may lead to antioxidant agent studies in
prophylactic treatment of migraine.

Keywords

headache, migraine, IMA, prolidase, interictal

Supporting Institution

Scientific Research Projects Coordination Unit of Kirikkale University

Project Number

2018/052

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