Telaprevir combination therapy in patients infected with hepatitis C virus genotype 4

Year 2016, Volume: 1 Issue: 3, 63 - 67, 30.12.2016

Bilgehan Aygen

Abstract

Background: The
sustained virological response (SVR) rate for genotype 4 (G4) HCV-infected
patients after pegylated interferon (PegIFN) and ribavirin (RBV) treatment is
approximately 60%. We aimed to investigate the efficacy and safety of
telaprevir (TVR) in combination with PegIFN and RBV in patients infected with
G4 HCV who were previously treated with PegIFN/RBV and failed to achieve SVR.

Material and Methods: The study included 10 patients: two prior relapsers, two
prior partial responders, and six prior null responders to PegIFN/RBV
treatment. The patients were given TVR/PegIFN/RBV for 12 weeks, followed by a
12-36 weeks PegIFN/RBV treatment. Rapid virological response (RVR), early
virological response (EVR), extended rapid virological response (eRVR), SVR,
and side effects of therapy were evaluated.

Results: The
mean age of the patients was 48.90±12.52 years and seven were female. All of
HCV isolates were typed as 4d. Interleukin (IL) 28B genotype was found CT in
seven patients and two patients had cirrhosis. Treatment was stopped within
four weeks because of the side effects in two patients. Three of the remaining
eight patients (37.5%) achived HVR, RVR, and eHVR. SVR was obtained in two of
these patients, but one patient relapsed. SVR rates were 25% in all patients.

Conclusion: TVR
combination therapy had limited antiviral activity in this patient population.
Further investigation of TVR combination therapy in patients with HCV G4
infection is warranted.

Keywords

Helicobacter pylori, babA2, cagA, gastric disorders

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