The Influence of Cigarette Smoking on Serum Lipid Levels and Cardiovascular Diseases in Elbasan District

Abstract

Cigarette smoking is considered an important risk factor for cardiovascular diseases which means the risk of coronary heart disease and stroke. Smoking is as widespread and significant as a risk factor that is called as “the leading preventable cause of disease and death”. The effects of cigarette smoking in atherosclerosis initiation and progression as well on its complications are mostly responsible for the enhanced cardio and cerebrovascular risk observed in smoking and non-smoking. The aim of this study was to see the effect of smoking on serum lipid levels and to compare the deference in the levels of total cholesterol, triglicerydes, HDL-cholesterol and LDL cholesterol levels in smokers and non-smokers. Fasting blood samples were collected for lipid profile from 350 persons that were presented in the hospital laboratory of Elbasan. 150 of them were regular smokers and 200 were non-smokers. The two groups matched about age and sex. A questionnaire was used to take information about their age, family history with dislipidemia, cigarette smoking, high blood pressure, alcohol consumption, height, weight, obesity, physical activity. The patients that match the exclusion criteria were excluded. The data collected were analysed using SPSS V20. We found that cigarette smokers were characterized from higher levels of total cholesterol (222±110.2 mg/dl) and LDL-cholesterol (148±23.7 mg/dl) (p <0.05) than non-smokers T C (168±96.3), LDL-ch (124±30.8). Mean serum triglycerides level were significantly high (p <0.01) at smokers than non-smokers. Smoking and a comparatively low HDL-cholesterol (p <0.01) were associated. Cigarette smoking effects on serum lipid levels which increases the risk for developing cardiovascular diseases.

Keywords

• cigarette smoking,HDL cholesterol,LDL cholesterol,triglycerides

References

1. Bruckert E, Baccara-Dinet, M. Mccoy F., (2005): High prevalence of low HDL-cholesterol in a pan–European survey of 8545 dyslipi-daemic patients. Med Res Opin.; 21:1927–1934
2. Durrington P, (2003) Dyslipidaemia. Lancet 362 (9385): 717–312 12957096.
3. Lloyd-Jones, DM. Larson MG, Beiser A, (1999): Lifetime risk of developing coronary heart disease. Lancet; 353:89 Freeman, DJ. Griffin, BA. Murray, E., (1993):. Smoking and plasma lipoproteins in man: effects on low density lipoprotein cholesterol levels and high density lipoprotein subfraction distribution. Eur J Clin Invest. 23, 630–40
4. Grundy SM, Cleeman JI, Bainey Merz CN, ( 2004): Implication of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines.Circulation.; 1 10, 227-239
5. McGill, HCJ. McMahan, CA. Malcom, GT. Oalmann, MC., (1997): Effects of serum lipoproteins and smoking on atherosclerosis in young men and women: the PDAY Research Group: Pathobiological Determinants of Atherosclerosis in Youth. Arterioscler Thromb Vasc Biol.;17, 95–106.
6. Naito HK, (2003) Coronary Artery Disease and Disorders of Lipid Metabolism. Clinical Chemistry: Theory. Analysis. Correlation. 4thEd., Kaplan, L.A.(Mosby, Inc. eds. St. Louis USA), 603
7. Third report of the National Cholesterol Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in Adults(Adult Treatment Panel III). Circulation 2002; 106: 3143
8. Yamaguchi, Y. Haginaka, J. Morimoto S, (2005): Facilitated nitration and oxidation of LDL in cigarette smokers. Eur J Clin Invest., 35, 186–93

9. Wilson PW, D’agostino RB, Levy D, (1998) Prediction of coronary heart disease using risk factor categories. Circulation; 97:1837