j. inst. sci. and tech. Journal of the Institute of Science and Technology 2536-4618 Igdir University 10.21597/jist.1278301 Chemical Engineering Kimya Mühendisliği Synthesis of New Benzenesulfonamides and Benzamides, Investigation of Carbonic Anhydrase and Cholinergic Effects Yeni Benzensülfonamitler ve Benzamitlerin Sentezi, Karbonik Anhidraz ve Kolinerjik Etkilerinin İncelenmesi https://orcid.org/0000-0002-6473-6338 Akıncıoğlu Akın Ağrı İbrahim Çeçen Üniversitesi, Merkezi Araştırma Laboratuvarı 09 01 2023 13 3 1814 1825 04 06 2023 06 04 2023 Copyright © 2011, Journal of the Institute of Science and Technology 2011 Journal of the Institute of Science and Technology

In this study, new benzene sulfonamide and benzamide derivatives were synthesized from 1-bromo-2,4-dimethoxybenzene (8) and 1-bromo-3,5-dimethoxybenzene (10). Inhibitory effects of synthesized compounds on hCA-I, hCA-II, AChE and BChE enzymes were investigated. The synthesis of the new amide derivatives 9 and 11 was carried out from the reaction of the starting compounds 8 and 10 with CSI. Treatment of methoxy-substituted benzenes with excess HSO3Cl followed by reaction of the resulting benzene sulfonyl chlorides with ammonia gave sulfonamides 16 and 17. It was determined that the synthesized sulfonamide and benzamide derivatives showed inhibition effect on hCA-I, hCA-II, AChE and BChE enzymes at micromolar level.

Bu çalışmada, 1-brom-2,4-dimetoksibenzen (8) ve 1-brom-3,5-dimetoksibenzen (10)’dan çıkılarak yeni benzensülfonamit ve benzamit türevleri sentezlendi. Sentezlenen bileşiklerin hCA-I, hCA-II, AChE ve BChE enzimleri üzerine inhibisyon aktiviteleri araştırıldı. Yeni amit türevleri 9 ve 11’in sentezi çıkış bileşikleri 8 ve 10’un CSI ile olan reaksiyonundan gerçekleştirildi. Metoksi substitue benzenlerin aşırı HSO3Cl ile muamelesi, akabinde elde edilen benzen sülfonil klorürlerin amonyakla reaksiyonu sülfonamitler 16 ve 17’yi verdi. Sentezi gerçekleştirilen sülfonamit ve benzamit türevlerinin hCA-I, hCA-II, AChE ve BChE enzimleri üzerine mikromolar seviyede inhibisyon etkisi gösterdikleri belirlenmiş oldu.

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