4-Amino-Tetrahidrokinolin Türevlerinin Organokatalizör Varlığında Sentezi ve Karakterizasyonu

Year 2020, Volume: 10 Issue: 1, 368 - 377, 01.03.2020

Mustafa Zahrettin Kazancıoğlu

https://doi.org/10.21597/jist.572079

Abstract

4-Aminotetrahidrokinolin türevleri; organo Brønsted asit katalizörü eşliğinde anilin, N-vinilkarbamat ve substitüe halojen içeren aldehitin bir balona konulmasıyla tek kademede sentezlendi. 3 bileşenli Povarov reaksiyonu yöntemi kullanıldı. 4 farklı 4-Aminotetrahidrokinolin türevi sentezlendi ve 1H, 13C, Infrared Spektroskopisi (IR), Erime noktası (EN) ve Yüksek Çözünürlüklü Kütle Spektroskopisi (HRMS) gibi çeşitli metotlar kullanılarak yapı karakterizasyonları yapıldı.

Keywords

Povarov reksiyonu, Tetrahidrokinolin, organokatalizör

Supporting Institution

Kilis 7 Aralık Üniversitesi Yusuf Şerefoğlu Sağlık Bilimleri Fakültesi, 79000, Kilis

Thanks

Kilis 7 Aralık Üniversitesi İleri Teknoloji Uygulama ve Araştırma Merkezi

Synthesis and Characterization of 4-Amino-Tetrahydroquinoline Derivatives via Organocatalyst

Abstract

4-Aminotetrahydroquinoline derivatives were synthesized as a single step by placing the aniline, N-vinylcarbamate and substituted halogen containing aldehyde in the presence of organo Brønsted acid catalyst. Three-component Povarov reaction method was used. Four different 4-aminotetrahydroquinoline derivatives were synthesized and Structural characterization was performed using various methods such as 1H, 13C, Infrared Spectroscopy (IR), melting point (MP) and High Resolution Mass Spectroscopy (HRMS).

Keywords

Povarov reaction, Tetrahydroquinoline, Organocatalyst

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