j istanbul univ fac dent Journal of Istanbul University Faculty of Dentistry 2149-4592 Istanbul University MAKSİLLOFASİYAL BÖLGEDE Uygun Serpil Apaydın Ayşegül 10 19 2010 42 1-2 11 17 10 19 2010 Copyright © 1967, Journal of Istanbul University Faculty of Dentistry 1967 Journal of Istanbul University Faculty of Dentistry

Maksilofasiyal bölgede tedavi sırasında veya travma gibi çeşitli nedenlerle sinir sistemini de etkileyebilecek değişik derecede hasarlar oluşabilmektedir. 20 yaş dişi operasyonları, enjeksiyonlar, implant uygulamaları, endodontik tedavi, TME artroskopisi, ortognatik cerrahi, künt ve delici travmalar ve benzerleri; hasar oluşturan nedenler arasında sayılabilir. Oluşan hasarların tedavisinde; farmakolojik ve cerrahi teknikler kullanılmaktadır. Bu yazımızda çalıştığımız alanda sinir hasarlarına yol açan nedenler ve onarımında kullanılan yöntemler karşılaştırılarak incelenmiştir.Anahtar Kelimeler: Periferik sinir, travma, rejenerasyon, farmakolojik ajan

 Periferik sinir travma rejenerasyon farmakolojik ajan Yiğit R: Kontrol sistemleri, sindirim ve boşal- tım fizyolojisi. Nobel Tıp Kitapevi. 2001. 2. Tirelioğlu S: Motor sinir defektlerinin onarı- mında duyusal sinir köprüsü kullanımı, uzman- lık tezi. Bursa, 2005. www.turkishneurosurgery.com 4. Ertaş Mustafa: Periferik Sinirlerin Anatomi ve Fizyolojisi, Zararlanmaları. İ.Ü. Nöroloji Ders Notları; 2000 Dec. www.itfnoroloji.com Caissie R, Goulet J, Fortin M, Morielli D: Iatrogenic paresthesia in the third division of the trigeminal nerve: 12 years of clinical experience. J Can Dent Assoc. 2005 Mar; 71 (3): 185-90. Andreasen JO, Laskin DM, Petersen JK: Textbook and Color Atlas of Tooth Impactions. Copenhagen. 1997; Chapter 16. Valmaseda-CE, Berini-Aytes L, Gay-Escoda C: Inferior alveolar nerve damage after lower third molar surgical extraction: a prospective study of 1117 surgical extractions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Oct; 92 (4): 377-83. Valmaseda-Castellon E, Berini-Aytes L, Gay- Escoda C: Lingual nerve damage after third lower molar surgical extraction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Nov; 90 (5): 567-73. Godoy ve arkadaşları: Frequency and evolution of lingual nerve lesions following lower third molar extraction. J Oral Maxillofac Surg. 2006 Mar; 64 (3): 402-7. Avendano AVC ve arkadaşları: Morbidity of third molar extraction in patients between 12 and 18 years of age. Oral Med Oral Patol Oral Cir Bucal 2005; 10: 422-31. Bacchetti P, Pogrel MA, Robert RC: Frequency of Trigeminal Nerve Injuries Folowing Third Molar Removal. J Oral Maxillofac Surg 63: 732-735, 2005. 13. Kaban LB, Perrott DH, Pogrel MA: Complications in Oral and Maxillofacial Surgery. Philadelphia. 1997; Chapter 6. Company, Brann CR, Brickley MR, Shepherd JP: Factors influencing nerve damage during lower third molar surgery. Br Dent J. 1999 May 22; 186 (10): 514-6. Rehman K, Webster K, Dover MS: Links between anaesthetic modality and nerve damage during lower third molar surgery. Br Dent J. 2002 Jul 13; 193 (1): 43-5. Kraut RA, Chahal O: Management of patients with trigeminal nerve injuries after mandibular implant placement. J Am Dent Assoc. 2002 Oct; 133 (10): 1351-4. Tatch Walter: Trigeminal Nerve Injuries and Repair. Department of Oral&Maxillofacial Surgery, UIC. 2002 Sep. Witton R, Brennan PA. Severe tissue damage and neurological deficit following extravasation of sodium hypochlorite solution during routine endodontic treatment. Br Dent J. 2005 Jun 25; 198 (12): 749-50. Pogrel MA. Damage to the inferior alveolar nerve as the result of root canal therapy. J Am Dent Assoc. 2007 Jan; 138 (1):65-9. Ichimura K, Nibu K, Tanaka T: Nerve paralysis after surgery in the submandibular triangle: review of University of Tokyo Hospital experience. Head Neck. 1997 Jan; 19 (1): 48- 53. Review. Weinberg S, Kryshtalskyj B: Analysis of facial and trigeminal nerve function after arthroscopic surgery of the temporomandibular joint. J Oral Maxillofac Surg. 54 (1): 40-43,1996. Hu J, Zou S, Tang Z, Wang D, Li J, Gao Z: Response of Schwann cells in the inferior alveolar nerve to distraction osteogenesis: an ultrastructural and immunohistochemical study. Int J Oral Maxillofac Surg. 2003 Jun; 32 (3): 318-24. Tang ZL, Hu J, Li JH, Zou SJ: Effect of nerve growth factor and Schwann cells on axon regeneration of distracted inferior alveolar nerve following mandibular lengthening. Chin J Traumatol. 2004 Apr; 7 (2): 81-6. Gratt BM, Shetty V, Saiar M, Sickles EA: Electronic thermography for the assessment of inferior alveolar nerve deficit. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Aug; 80 (2): 153-60. Teltzrow T, Kramer FJ, Schulze A, Baethge C, Brachvogel P: Perioperative complications following sagittal split osteotomy of the mandible. J Craniomaxillofac Surg. 2005 Oct; 33 (5): 307-13. Lydiatt DD: Litigation and the lingual nerve. J Oral Maxillofac Surg. 2003 Feb; 61 (2): 197- 200; discussion 200. Vora AR, Loescher AR, Craig GT, Boissonade FM, Robinson PP: A light microscopical study on the structure of traumatic neuromas of the human lingual nerve. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Apr; 99 (4): 395-403. Chow HT, Teh LY: Sensory impairment after resection of the mandible: a case report of 10 cases. J Oral Maxillofac Surg. 2000 Jun; 58 (6): 629-35. Seo K, Tanaka Y, Terumitsu M, Someya G. Efficacy of steroid treatment for sensory impairment after orthognathic surgery. J Oral Maxillofac Surg. 2004 Oct; 62 (10): 1193-7. Heiduschka P, Thanos S. Cortisol promotes survival and regeneration of axotomised retinal ganglion cells and enhances effects of aurintricarboxylic acid. Graefes Arch Clin Exp Ophthalmol. 2006 Nov; 244 (11): 1512-21. Palaoğlu S, Akbay A, Bozkurt G. Akut omurilik yaralanmasının tedavisinde iyileşmeyi hızlandı- ran farmakolojik ve cerrahi girişimler. Türkiye fiziksel tıp ve rehabilitasyon dergisi. 2006; 48 (6). Hall ED, Springer JE. Neuroprotection and acute spinal cord injury: a reappraisal. NeuroRx. 2004 Jan; 1(1): 80-100. Werner PC. New drugs for improving injury outcome in spinal cord injuries. West J Med. 1997 Apr; 166 (4): 271-2. Mocchetti I. Exogenous gangliosides, neuronal plasticity and repair, and the neurotrophins. Cell Mol Life Sci. 2005 Oct; 62 (19-20): 2283-94. Thompson SN, Gibson TR, Thompson BM, Deng Y, Hall ED. Relationship of calpain- mediated proteolysis to the expression of axonal and synaptic plasticity markers following traumatic brain injury in mice. Exp Neurol. 2006 Sep; 201 (1): 253-65. Epub 2006 Jun 30. Li M, Ona VO, Chen M, Kaul M, Tenneti L, Zhang X, Stieg PE, Lipton SA, Friedlander RM. implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury. Neuroscience. 2000; 99 (2): 333-42. therapeutic McCarthy Joseph: Plastic Surgery. W.B. Saunders Volume 1. Philadelphia. 1990; Smith KG, Robinson PP: The re-innervation of the tongue and salivary glands after lingual nerve repair by stretch, sural nerve graft or frozen muscle graft. J Dent Res. 1995 Dec; 74 (12): 1850-60. Rath EM: Skeletal muscle autograft for repair of the human inferior alveolar nerve: a case report. J Oral Maxillofac Surg. 2002 Mar; 60 (3): 330-4. Choi BH, Kim BY, Huh JY, Lee SH, Zhu SJ, Jung JH, Cho BP: Microneural anastomosis using cyanoacrylate adhesives. Int J Oral Maxillofac Surg. 2004 Dec; 33 (8): 777-80. Junior ED, Valmaseda-Castellon E, Gay- Escoda C: Facial nerve repair with epineural suture and anastomosis using fibrin adhesive: an experimental study in the rabbit. J Oral Maxillofac Surg. 2004 Dec; 62 (12): 1524-9. Choi BH, Zhu SJ, Kim BY, Huh JY, Lee SH, Jung JH: Transplantation of cultured bone marrow stromal cells to improve peripheral nerve regeneration. Int J Oral Maxillofac Surg. 2005 Jul; 34 (5): 537-42. Epub 2005 Jan 26. Smith KG, Yates JM, Robinson PP: The effect of nerve growth factor on functional recovery after injury to the chorda tympani and lingual nerves. Brain Res. 2004 Sep 10; 1020 (1-2): 62- 72. Robinson PP, Yates JM, Smith KG: An electrophysiological study into the effect of neurotrophin-3 on functional recovery after lingual nerve repair. Arch Oral Biol. 2004 Oct; 49 (10): 763-75. Yates JM, Smith KG, Robinson PP: The effect of brain-derived neurotrophic factor on sensory and autonomic function after lingual nerve repair. Exp Neurol. 2004 Dec; 190 (2): 495- 505. Zuniga JR, Chen N, Phillips CL: Chemosensory and somatosensory regeneration after lingual nerve repair in humans. J Oral Maxillofac Surg. 1997 Jan; 55 (1): 2-13; discussion 13-4. Hillerup S: Chemosensory and somatosensory regeneration after lingual nerve repair in humans. J. Oral Maxillofac Surg. 1997; 55: 13- 14.