j istanbul univ fac dent

Journal of Istanbul University Faculty of Dentistry

2149-4592

Istanbul University

10.17096/jiufd.97067

Obezite ve Periodontitis Arasındaki Karşılıklı İlişki

THE TWO-WAY RELATIONSHIP BETWEEN OBESITY AND PERIODONTITIS-Obezite ve Periodontitis Arasındaki Karşılıklı İlişki

Karabey

Volkan

Çifcibaşı

Emine

Çintan

Serdar

11 18 2014

48 3 75 81 11 18 2014

1967

Journal of Istanbul University Faculty of Dentistry

Periodontitis ve obezite iki kronik enflamatuar hastalıktır. Obezite ve periodontitis sistemik enflamasyonla ilgili olduklarından bu iki hastalığın ortak patofizyolojiye sahip olduğu söylenebilir. TNF-alfa ve IL-6 obezite ve periodontitisin patofizyolojisinde yer alan sitokinlerdir. Bu sitokinlerin seviyeleri obezite ve periodontitis ile birlikte artar. Resistin immun hücreler tarafından üretilir ve bu yüzden de enflamatuar sürecin aktivasyonunda yer alır. Resistinin pro-enflamatuar özellikleri TNF-alfa ve IL-6 salınımı ve adiponektinin anti-enflamatuar etkilerinin bozulmasıdır. Periodontitiste serumda resistin seviyesi artmaktadır. Aynı zamanda adipoz dokular da adiponektin gibi bazı anti-enflamatuar faktörleri salgılamaktadır. Obez bireylerde normal ağırlıktaki bireylere göre plazmada azalmış adiponektin seviyeleri görülmektedir. Ayrıca bilimsel kanıtlar periodontitisli bireylerde serum adiponektin seviyesinin ve fonksiyonunun azaldığını göstermektedir. Sonuç olarak, periodontitis ve obezite çeşitli sitokinler, proteinler, ve vitaminler aracılığıyla birbirleri ile ilişkili iki hastalıktır.

ABSTRACTPeriodontitis and obesity are two chronic inflammatory diseases. Since obesity and periodontitisare associated with systemic inflammation, these two situations are linked by common pathophysiology.TNF-alfa and IL-6 are cytokines that are involved in the pathophysiology of both obesity andperiodontitis. The levels of these cytokines increase with obestiy and periodontitis. Resistin is producedby immune cells and therefore, is related to the activation of inflammatory processes. Increasedresistin serum levels have been associated with periodontitis. Adipose tissues also secrete some antiinflammatoryfactors, such as adiponectin. Plasma levels of adiponectin are decreased in individualswho are obese, compared with persons who are normal weight. Furthermore, evidence suggests atrend toward decreased adiponectin serum levels and reduced adiponectin function in individuals withperiodontitis. In conclusion, periodontitis and obesity are diseases that are associated through variouscytokines, proteins, vitamins, etc.Keywords: Periodontitis, obesity, TNF-alpha, IL-6, resistinÖZPeriodontitis ve obezite iki kronik enflamatuar hastalıktır. Obezite ve periodontitis sistemik enflamasyonlailgili olduklarından bu iki hastalığın ortak patofizyolojiye sahip olduğu söylenebilir. TNF-alfave IL-6 obezite ve periodontitisin patofizyolojisinde yer alan sitokinlerdir. Bu sitokinlerin seviyeleriobezite ve periodontitis ile birlikte artar. Resistin immun hücreler tarafından üretilir ve bu yüzden deenflamatuar sürecin aktivasyonunda yer alır. Resistinin pro-enflamatuar özellikleri TNF-alfa ve IL-6salınımı ve adiponektinin anti-enflamatuar etkilerinin bozulmasıdır. Periodontitiste serumda resistinseviyesi artmaktadır. Aynı zamanda adipoz dokular da adiponektin gibi bazı anti-enflamatuar faktörlerisalgılamaktadır. Obez bireylerde normal ağırlıktaki bireylere göre plazmada azalmış adiponektin seviyelerigörülmektedir. Ayrıca bilimsel kanıtlar periodontitisli bireylerde serum adiponektin seviyesininve fonksiyonunun azaldığını göstermektedir. Sonuç olarak, periodontitis ve obezite çeşitli sitokinler,proteinler, ve vitaminler aracılığıyla birbirleri ile ilişkili iki hastalıktır.Anahtar kelimeler: Periodontit, obezite, TNF-alfa, IL-6, rezistin

Periodontitis obesity TNF-alpha IL-6 resistin

Periodontit obezite TNF-alfa IL-6 rezistin

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