A Case of Subcutaneous and Gastrointestinal Basidiobolomycosis in Singapore

Year 2017, Volume: 07 Issue: 03, 151 - 155, 15.09.2017

Teh Yii Ean Tan Ban Hock Limin Wijaya

https://doi.org/10.5799/jmid.367574

Abstract

Entomophthoromycosis
due to Basidiobolus is a known cause of subcutaneous zygomycosis. It
occasionally causes invasive disease involving the gastrointestinal tract. We
describe a case of proven subcutaneous entomophthoromycosis, with subsequent
development of gastrointestinal basidiobolomycosis, in a 67 year old
Singaporean Chinese male. He presented with a progressively enlarging left
inguinal mass with intra-abdominal extension, causing compression of the ureters
and hydronephroses. He underwent multiple biopsies to ascertain the cause of
the mass. Workup for malignancy, bacteria, fungal, parasitic and tuberculous
infections were negative.  He developed
worsening gastrointestinal distension a year from initial presentation. Imaging
showed mucosal thickening extending from the descending colon to the rectum.
Based on the clinical presentation, he was treated as for basidiobolomycosis.
He responded poorly to treatment and passed away two months after initiation of
therapy. With the help of our counterparts in India, we proved our clinical
suspicion by polymerase chain reaction on tissue specimen. 

Keywords

Basidiobolomycosis, Entomophthoromycosis, Gastrointestinal, Inguinal mass

References

• 1. El-Shabrawi MHF, Kamal NM, Al-Harbi RJA, Voigt K, Al-Malki T. Gastrointestinal basidiobolomycosis: an emerging fungal infection causing bowel perforation in a child. J Med Microbiol 2011;60:1395-1402. Chapter in a book: Motoyama EK. Respiratory physiology in infants and children. In: Motoyama EK, Davis PJ, eds. Smith's Anesthesia for Infants and Children, 5th edn. St. Louis: C.V. Mosby, 1990:11-76. 2. Chapter in a book: Kontoyiannis DP. Agents of Mucormycosis and Entomophthoramycosis. In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases Volume 2, 7th edn. Philadelphia: Churchill Livingstone, 2010: 3266-3267. 3. Arjmand R, Karimi A, Dashti AS, Kadivar M. A Child with Intestinal Basidiobolomycosis. Iran J Med Sci 2012; 37(2):134-136. 4. Lyon GM, Smilack JD, Komatsu KK, et al. Gastrointestinal Basidiobolomycosis in Arizona: Clinical and Epidemiological Characteristics and Review of the Literature. Clin Infect Dis 2011; 32:1448-1455. 5. Vikram HR, Smilack JD, Leighton JA, Crowell MD, De Petris G. Emergence of Gastrointestinal Basidiobolomycosis in the United States, With a Review of Worldwide Cases. Clin Infect Dis 2012;54(12):1685-1691. 6. Ejtehadi F, Anushiraviani A, Bananzadeh A, Geramizadeh B. Gastrointestinal Basidiobolomycosis Accompanied by Liver Involvement: A Case Report. Iran Red Cresent Med J 2014; 16(9):e14109. 7. Alsaleem K, Al-Mehaidib A, Banemai M, Hussain IB, Faqih M, Mehamadi A. Gastrointesinal basidiobolomycosis: mimicking Crohn’s disease case report and review of the literature. Ann Saudi Med 2013; 33(5):500-504. 8. Alsheri AH, Alsheri A, Bawahab MA, et al. Basidiobolomycosis: An Emerging Fungal Infection of the Gastrointestinal Tract in Adults. Am J Infect Dis 2013; 9(1):1-6. 9. Al-Maani AS, Paul G, Jardani A, et al. Gastrointestinal Basidiobolomycosis: First case report from Oman and literature review. Sultan Qaboos Univ Med J 2013; 14(2):241-244 10. Khan ZU, Khoursheed M, Makar R, et al. Basidiobolous ranarum as an Etiologic Agent of Gastrointestinal Zygomycosis. J Clin Microbiol 2001; 39(6):2360-2363 11. Janagond AB, Gouripur K, Dillirani V, Thnmozhivalli PR. Subcutaneous Basidiobolomcosis, an unusual case. Int J Biol Med Res 2013;4(1):2983-2985 12. Albaradi BA, Babiker AM, Al-Qahtani HS. Successful treatment of gastrointestinal basidiobolomycosis with voriconazole without surgical intervention. J Trop Pediatr 2014; 60(6):476-479 13. Rose SR, Lindsley MD, Hurst SF, Paddock CD, Damodaran T, Bennett J. Gastrointestinal basidiobolomycosis treated with posaconazole. Med Mycol Case Rep 2013; 2:11-14 14. Krishnan SG, Sentamilselvi G, Kamalam A, Das KA, Janaki C. Entomophthoromycosis in India-a 4 year study. Mycoses 1998; 41(1-2):55-58. 15. Nazir Z, Hasan R, Pervaiz S, Alam M, Moazam F. Invasive retroperitoneal infection due to Basidiobolus ranarum with response to potassium iodide: case report and review of the literature. Ann Trop Paediatr 1997; 17:161-164.