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            <front>

                <journal-meta>
                                                                <journal-id>jnlm</journal-id>
            <journal-title-group>
                                                                                    <journal-title>Doğal Yaşam Tıbbı Dergisi</journal-title>
            </journal-title-group>
                                        <issn pub-type="epub">2757-7880</issn>
                                                                                            <publisher>
                    <publisher-name>Hayrullah YAZAR</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id/>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>Public Health</subject>
                                                            <subject>Environmental Health</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Halk Sağlığı</subject>
                                                            <subject>Çevre Sağlığı</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                        <article-title>Obezite ve kardiyak belirteçler arasındaki muhtemel ilişki</article-title>
                                                                                                                                                                                                <trans-title-group xml:lang="en">
                                    <trans-title>Possible association between obesity and cardiac markers</trans-title>
                                </trans-title-group>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0001-9350-8708</contrib-id>
                                                                <name>
                                    <surname>Yöntem</surname>
                                    <given-names>Mustafa</given-names>
                                </name>
                                                                    <aff>NECMETTİN ERBAKAN ÜNİVERSİTESİ, FEN FAKÜLTESİ</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                <name>
                                    <surname>Koçak</surname>
                                    <given-names>Emel</given-names>
                                </name>
                                                                    <aff>Kütahya Sağlık Bilimleri Üniversitesi</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                <name>
                                    <surname>Yerli</surname>
                                    <given-names>Merve</given-names>
                                </name>
                                                                    <aff>DUMLUPINAR ÜNİVERSİTESİ</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0001-7098-5982</contrib-id>
                                                                <name>
                                    <surname>Erdoğdu</surname>
                                    <given-names>Behiç Selman</given-names>
                                </name>
                                                                    <aff>NECMETTİN ERBAKAN ÜNİVERSİTESİ, FEN FAKÜLTESİ</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20211231">
                    <day>12</day>
                    <month>31</month>
                    <year>2021</year>
                </pub-date>
                                        <volume>3</volume>
                                        <issue>2</issue>
                                        <fpage>38</fpage>
                                        <lpage>47</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20211209">
                        <day>12</day>
                        <month>09</month>
                        <year>2021</year>
                    </date>
                                                    <date date-type="accepted" iso-8601-date="20211226">
                        <day>12</day>
                        <month>26</month>
                        <year>2021</year>
                    </date>
                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 2019, Journal of Natural Life Medicine</copyright-statement>
                    <copyright-year>2019</copyright-year>
                    <copyright-holder>Journal of Natural Life Medicine</copyright-holder>
                </permissions>
            
                                                                                                <abstract><p>AmaçKardiyovasküler hastalık riski ve buna bağlı ortaya çıkan mortalitenin en önemli nedenleri arasında obezite de gösterilmektedir. Çalışmada amacımız, obezite ve kardiyak belirteçler arasındaki ilişkiyi incelemektir.Materyal ve MetotÇalışmada obez ve kontrol olmak üzere, 2 grup oluşturuldu. Obezite grubu, obezite okuluna başvuran bireylerden oluştu. Kontrol grubu, sağlıklı ve obez olmayan bireylerden oluşturuldu. Gruplar oluşturulurken yaş ortalama değerlerine dikkat edildi. Çalışmaya katılan bireylerin VKİ (Vücut Kitle İndeksi) ölçümleri yapıldı ve kan örneklerinden biyokimyasal testler çalışıldı.  Elde edilen veriler GraphPad Prism version 6.05 (GraphPad Software, Inc., CA, USA) programı kullanılarak analiz edildi. Değişkenler arasındaki ilişkilerin incelenmesi için Pearson‟s korelasyon analizleri yapıldı. P  &amp;lt; 0.05 istatistiksel anlamlılık düzeyi olarak kabul edildi.BulgularÇalışmamıza 133 obez ve 126 obez olmayan toplam 259 katılımcı dahil edildi. Grupların yaş ortalaması, obez grupta 48.2± 6.5 ve obez olmayan grupta 46.2± 8.9 idi. Yaş ortalamaları arasında anlamlı bir farklılık bulunamadı (p&amp;gt;0.05)). Yapılan biyokimyasal testlerden; Total kolesterol, trigliserit, LDL kolesterol, CK MB mass ve kardiyak troponin I (cTnI) düzeylerinin gruplar arasında anlamlı farklılıkta olduğu görüldü (p 0.05). SonuçObezite, kardiyak belirteçler üzerinde anlamlı derecede yükseltici etkiye sahiptir. Öte yandan; bu etkinin incelenmesinde, fiziksel aktivitenin de içinde olduğu araştırmalar daha aydınlatıcı olacaktır.</p></abstract>
                                                                                                                                    <trans-abstract xml:lang="en">
                            <p>AIMObesity is shown to be responsible for cardiovascular disease risk and related mortality. The aim of the present study is to investigate the relationship between obesity and cardiac markers. MATERIALS AND METHODThe study has formed two groups as obese and controls. The obesity group consisted of individuals who applied to the obesity school. Non-obese and healthy individuals are included to the control group. Mean age values were considered in formation of groups. After Body Mass Index (BMI) measurements, blood samples of the participants were taken for biochemical analyzes. The obtained data were analyzed using GraphPad Prism version 6.05 (GraphPad Software, Inc., CA, USA). Pearson&#039;s correlation analyzes were performed to examine the relationships between the variables. A p  &amp;lt; 0.05 was accepted as statistically significant.RESULTA total of 259 participants, 133 obese and 126 non-obese, were included to the study group. Mean ages were 48.2± 6.5 in obese group and 46.2± 8.9 in healthy controls. Any significant decrease was not detected among the mean ages (p &amp;gt; 0.05). Total cholesterol, triglyceride, LDL-cholesterol, CK-MB and cardiac troponin I (cTnI) levels were found significantly different among the groups (p  &amp;lt; 0.05). Besides, HDL-cholesterol levels was not significantly different between both of the groups (p &amp;gt; 0.05).CONCLUSIONObesity has a significant elevating effect on cardiac markers. It is thought that further studies including physical activity will be more enlightening investigation of these effects.</p></trans-abstract>
                                                            
            
                                                            <kwd-group>
                                                    <kwd>Kardiyak belirteçler</kwd>
                                                    <kwd>  lipit parametreleri</kwd>
                                                    <kwd>  obezite</kwd>
                                            </kwd-group>
                                                        
                                                                            <kwd-group xml:lang="en">
                                                    <kwd>Cardiac markers</kwd>
                                                    <kwd>  lipid parameters</kwd>
                                                    <kwd>  obesity</kwd>
                                            </kwd-group>
                                                                                                            </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">Ahirwar R., Mondal PR. (2019). Prevalence of obesity in India: A systematic review. Diabetes Metab Syndr,13(1):318-321. doi: 10.1016/j.dsx.2018.08.032.</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">Altunkaynak BZ., Özbek E. (2006). Obezite: Nedenleri ve tedavi seçenekleri. Van Tıp Dergisi, 13 (4): 138 142.</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">Antipatis, V. J., Gill, T. P. (2002). Epidemiyoloji, Bölüm 1., Ġnternational Textbook of Obesity. 1. Baskı, John Wiley and Sons Ltd.</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">Baskın, Y., Yiğitbaşı, T., Afacan, G., Bağbozan, G. (2008). İnsülin direnci olan erişkin obezlerde lipoprotein (a) ile lipid parametreleri. Türk Klinik Biyokimya Dergisi, 6 (2):65 71.</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">Çetin Ş., Muhtaroğlu, S., Keti, D. B., Hatipoğlu, N., Kurtoğlu, S. (2013). Obez çoçuklarda malondialdehit seviyesi ve paraoksonaz 1 aktivitesinin değerlendirilmesi. Erciyes Üniversitesi Sağlık Bilimleri Dergisi, 22 (1): 64 69.</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">De Lorenzo A, Soldati L, Sarlo F, Calvani M, Di Lorenzo N, Di Renzo L. (2016). New obesity classification criteria as a tool for bariatric surgery indication. World J Gastroenterol. 14;22(2):681-703. doi: 10.3748/wjg.v22.i2.681.</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">Eijsvogels Thijs, M. H., Veltmeijer Matthijs, T. W., George, K., Hopman Maria, T. E., Thijjsen Dick, H. J. (2012). The impact of obesity on cardiac troponin levels after prolonged exercise in humans. European Journal of Applied Physiology, 112 (5): 1725 1732.</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">Helvacı, A., Tipi, F. F., Belen, E. (2014). Obeziteye bağlı kardiyovasküler hastalıklar. Ok Meydanı Tıp Dergisi, 30 (1): 5 14.</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">Kachur S., Lavie CJ., de Schutter A., Milani RV., Ventura HO. (2017). Obesity and cardiovascular diseases. Minerva Med, 108(3):212-228. doi: 10.23736/S0026-4806.17.05022-4.</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">Keskin, S., Sayalı, E., Temeloğlu, E., Ekizoğlu, Ġ. (2005). Obezite ve inflamasyon, Türkiye klinikleri. Journal of Medical Sciences, 25: 636 641.</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">Kutkutürk, F., Sertkaya, A. Ç., Azezli, A. (2012). Obez kadınlarda serum ferritin düzeyleri ve kardiyovasküler risk göstergeleri arasındaki ilişki. Çağdaş Tıp Dergisi; 2 (2):82 86.</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">Seravalle G, Grassi G. (2017). Obesity and hypertension. Pharmacol Res, 122:1-7. doi: 10.1016/j.phrs.2017.05.013.</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">Söylemez, N., Demirbağ, R., Sezen, Y., Yıldız, A., Akpınar, O. (2010). Vücut kitle indeksine göre leptin ve adiponektin seviyeleri ve bunların oksidatif parametrelerle ilişkisi. Anadolu Kardiyoloji Dergisi, 10: 391 6.</mixed-citation>
                    </ref>
                                    <ref id="ref14">
                        <label>14</label>
                        <mixed-citation publication-type="journal">Ndumele, C., Coresh, J., Lazo, M., Hoogeveen, R. C., Blumenthal, R. S., Folsom, A.R., Selvin, E., Ballantyne, C. M., Nambi, V. (2014).</mixed-citation>
                    </ref>
                                    <ref id="ref15">
                        <label>15</label>
                        <mixed-citation publication-type="journal">Obesity subclinal myocardial injury and incident heart failure. Journal of Clinical Heart Failure, 2 (6):600 607.</mixed-citation>
                    </ref>
                                    <ref id="ref16">
                        <label>16</label>
                        <mixed-citation publication-type="journal">Reddy, GC., Ksumanjali, G., Sharada, AHR., Rao, P. (2004). Cardiac troponin T and CKMB mass Levels in Cardiac non cardiac disease. Indian Journal of Clinical Biochemistry, 19 (2): 91 94.</mixed-citation>
                    </ref>
                                    <ref id="ref17">
                        <label>17</label>
                        <mixed-citation publication-type="journal">Yazar H. (2020). Determination of Various Factors Affecting Blood Lipids. 2nd Edition, Lambert Academic Publicatishing (LAP), ISSN: 978-620-2-78666-9. Pp: 19-20.</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
