jnrs

Journal of New Results in Science

1304-7981

Tokat Gaziosmanpasa University

Proteomics and Intermolecular Interactions Biochemistry and Cell Biology (Other)

Proteomik ve Moleküller Arası Etkileşimler Biyokimya ve Hücre Biyolojisi (Diğer)

Stress Markers and Post-COVID Insomnia: Investigating Copeptin and Melatonin Levels in Post-COVID-19

https://orcid.org/0000-0002-2796-9511

Güzelgül

Figen

TOKAT GAZIOSMANPASA UNIVERSITY

https://orcid.org/0000-0003-0695-326X

Abdelmageed

Marwa

TOKAT GAZIOSMANPASA UNIVERSITY

https://orcid.org/0000-0002-7901-3466

İnönü Köseoğlu

Handan

TOKAT GAZIOSMANPASA UNIVERSITY

https://orcid.org/0000-0003-4714-6894

Akpınar Aslan

Esma

TOKAT GAZIOSMANPASA UNIVERSITY

04 30 2026

15 1 84 94 12 04 2025 03 02 2026

2012

Journal of New Results in Science

Insomnia is a prevalent symptom affecting 5.4% to 64% of individuals who have recovered from COVID-19. In this study, we aimed to elucidate the role of copeptin and melatonin in the pathogenesis of post-COVID-19 and insomnia in COVID-19 survivors. Thirty COVID-19-recovered patients and fifteen healthy controls were included in the study. Patients were categorized into two groups: individuals with post-COVID insomnia (Insomnia Severity Index [ISI] above 15, n=10) and those without (n=20). Insomnia patients received either Trazodone 50 mg or Mirtazapine 15 mg as a sleep disturbance treatment once a day for three months. Serum copeptin and melatonin were evaluated. Melatonin and copeptin levels demonstrated a statistical significance between the study groups (p

Melatonin Copeptin COVID-19 insomnia

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

There is no project number

World Health Organization. WHO COVID-19 dashboard – Cases (2025) Accessed 10 July 2025.

M. Garg, M. Maralakunte, S. Garg, S. Dhooria, I. Sehgal, A. S. Bhalla, R. Vijayvergiya, S. Grover, V. Bhatia, …, M. S. Sandhu, The conundrum of ‘Long-COVID-19ʹ, a narrative review, International Journal of General Medicine 14 (2021) 2491–2506.

J. B. Soriano, S. Murthy, J. C. Marshall, P. Relan, J. V. Diaz, A clinical case definition of post-COVID-19 condition by a Delphi consensus, Lancet. Infectious Diseases 22 (4) (2022) e102–e107.

D. Gonçalves, J. P. Costa, S. Silva, M. Tavares, H. Barros, P. Meireles, The association between probable POST‐COVID ‐19 condition and sleep‐related parameters: A longitudinal study of non‐hospitalised patients, Journal of Sleep Research 33 (6) (2024) e14215.

O. V. Kotova, V. E. Medvedev, M. G. Poluektov, A. A. Belyaev, E. S. Akarachkova, Sleep disorders in Post-COVID syndrome: A psychiatric or neurological problem?, Neuroscience and Behavioral Physiology 53 (1) (2023) 16–20.

V. Chippa, A. Aleem, F. Anjum. Postacute coronavirus (COVID-19) syndrome, StatPearls [Internet], Treasure Island (FL): StatPearls Publishing, 2025.

N. L. Rauwerda, T. A. Kuut, A. M. J. Braamse, I. Csorba, P. Nieuwkerk, A. Van Straten, H. Knoop, Insomnia and sleep characteristics in post COVID-19 fatigue: A cross-sectional case-controlled study, Journal of Psychosomatic Research 177 (2024) 111522.

R. Tedjasukmana, A. Budikayanti, W. R. Islamiyah, A. M. A. L. Witjaksono, M. Hakim, Sleep disturbance in post COVID-19 conditions: Prevalence and quality of life, Frontiers in Neurology 13 (2023) 1095606.

H. M. Al-Kuraishy, A. I. Al-Gareeb, S. Qusti, E. M. Alshammari, F. O. Atanu, G. E.- S. Batiha, Arginine vasopressin and pathophysiology of COVID-19: An innovative perspective, Biomedicine & Pharmacotherapy 143 (2021) 112193.

E. Solomonova, Y. E. A. Lee, S. Robins, L. King, N. Feeley, I. Gold, B. Hayton, E. Libman, C. Nagy, …, P. Zelkowitz, Sleep quality is associated with vasopressin methylation in pregnant and postpartum women with a history of psychosocial stress, Psychoneuroendocrinology 107 (2019) 160–168.

M. Abdelmageed, F, Güzelgül, Copeptin: Up-to-date diagnostic and prognostic role highlight, Analytical Biochemistry 673 (2023) 115181.

R. J. Dressle, B. Feige, K. Spiegelhalder, C. Schmucker, F. Benz, N. C. Mey, D. Riemann, HPA axis activity in patients with chronic insomnia: A systematic review and meta-analysis of case–control studies, Sleep Medicine Reviews 62 (2022) 101588.

D. A. Schmid, A. Wichniak, M. Uhr, M. Ising, H. Brunner, K. Held, J. C. Weikel, A. Sonntag, A. Steiger, Changes of sleep architecture, spectral composition of sleep EEG, the nocturnal secretion of cortisol, ACTH, GH, prolactin, melatonin, ghrelin, and leptin, and the DEX-CRH test in depressed patients during treatment with mirtazapine, Neuropsychopharmacology 31 (4) (2006) 832–844.

K. Y. Jaffer, T. Chang, B. Vanle, J. Dang, A. J. Steiner, N. Loera, M. Abdelmesseh, I. Danovitch, W. W. Ishak, Trazodone for insomnia: A systematic review, Innovations in Clinical Neuroscience 14 (7–8) (2017) 24–34.

C. M. Morin, G. Belleville, L. Bélanger, H. Ivers, The insomnia severity index: Psychometric indicators to detect insomnia cases and evaluate treatment response, Sleep 34 (5) (2011) 601–608.

H. T. X. Hoang, W. F. Yeung, Q. T. M. Truong, C. T. Le, A. T. M. Bui, Q. V. Bui, Q. T. L. Le, L. H. Quach, Sleep quality among non-hospitalized COVID-19 survivors: A national cross-sectional study, Frontiers in Public Health 11 (2024) 1281012.

X. X. Zhang, S. Y. Sun, Z. J. Ma, Z. Y. Li, Y. S. Zhou, Y. Yang, J. X. Rao, P. Zhang, X. Y. Kong, …, G. H. Chen, Changed nocturnal levels of stress-related hormones couple with sleep-wake states in the patients with chronic insomnia disorder: A clinical pilot study, Sleep Medicine 117 (2024) 177–183.

P. L. Nonglait, S. V. Madhu, N. Raizada, A. Aggarwal, R. Ahmed, M. Aslam, High level of psychological stress in COVID-19 recovered individuals: Role of copeptin as a potential biomarker, Frontiers in Psychology 14 (2023) 1253396.

J. T. Chen, P. Zhang, X. Y. Kong, Y. J. Ge, X. Y. Li, S. Yang, S. He, G. H. Chen, Changed serum levels of CD62E+, angiotensin II and copeptin in patients with chronic insomnia disorder: A link between insomnia and stroke?, Sleep Medicine 91 (2022) 96–104.

S. Schreiber, C. G. Pick, Trazodone and mirtazapine: A possible opioid involvement in their use (at low dose) for sleep?, Medical Hypotheses 136 (2020) 109501.

S. M. Stahl, Mechanism of action of trazodone: A multifunctional drug, CNS Spectrums, 14 (10) (2009) 536–546.

C. L. DeVane, D. R. Grothe, S. L. Smith, Pharmacology of antidepressants: Focus on nefazodone, Journal of Clinical Psychiatry 63 (1) (2002) 10–17.

A. Agorastos, A. Sommer, A. Heinig, K, Wiedemann, C. Demiralay, Vasopressin surrogate marker copeptin as a potential novel endocrine biomarker for antidepressant treatment response in major depression: A pilot study, Frontiers in Psychiatry 11 (2020) 453.

M. Adamsson, T. Laike, T. Morita, Annual variation in daily light exposure and circadian change of melatonin and cortisol concentrations at a northern latitude with large seasonal differences in photoperiod length, Journal of Physiological Anthropology 36 (1) (2017) 6.

B. Rzepka-Migut, J. Paprocka, Melatonin-measurement methods and the factors modifying the results. A systematic review of the literature, International Journal of Environmental Research and Public Health 17 (6) (2020) 1916.