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            <front>

                <journal-meta>
                                                                <journal-id>j cukurova anesth surg</journal-id>
            <journal-title-group>
                                                                                    <journal-title>Journal of Cukurova Anesthesia and Surgical Sciences</journal-title>
            </journal-title-group>
                                        <issn pub-type="epub">2667-498X</issn>
                                                                                            <publisher>
                    <publisher-name>Merthan TUNAY</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id pub-id-type="doi">10.36516/jocass.1793221</article-id>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>Cardiovascular Surgery</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Kalp ve Damar Cerrahisi</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                        <article-title>The Effect of Hypothermic and Normothermic Cardiopulmonary Bypass on Metabolic and Haemodynamic Parameters</article-title>
                                                                                                                                                                                                <trans-title-group xml:lang="tr">
                                    <trans-title>Hipotermik ve Normotermik Kardiyopulmoner Bypassın Metabolik ve Hemodinamik Parametreler Üzerine Etkisi</trans-title>
                                </trans-title-group>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0001-6863-1907</contrib-id>
                                                                <name>
                                    <surname>Padak</surname>
                                    <given-names>Mahmut</given-names>
                                </name>
                                                                    <aff>HARRAN ÜNİVERSİTESİ</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0001-9157-7830</contrib-id>
                                                                <name>
                                    <surname>Dikme</surname>
                                    <given-names>Reşat</given-names>
                                </name>
                                                                    <aff>HARRAN UNIVERSITY, HEALTH SERVICES VOCATIONAL SCHOOL</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20251231">
                    <day>12</day>
                    <month>31</month>
                    <year>2025</year>
                </pub-date>
                                        <volume>8</volume>
                                        <issue>4</issue>
                                        <fpage>417</fpage>
                                        <lpage>423</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20250929">
                        <day>09</day>
                        <month>29</month>
                        <year>2025</year>
                    </date>
                                                    <date date-type="accepted" iso-8601-date="20251217">
                        <day>12</day>
                        <month>17</month>
                        <year>2025</year>
                    </date>
                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 2018, Journal of Cukurova Anesthesia and Surgical Sciences</copyright-statement>
                    <copyright-year>2018</copyright-year>
                    <copyright-holder>Journal of Cukurova Anesthesia and Surgical Sciences</copyright-holder>
                </permissions>
            
                                                                                                <abstract><p>Aim: The aim of this study is to investigate the changes in metabolic and haemodynamic parameters over time in patients undergoing coronary artery bypass grafting with hypothermic and normothermic cardiopulmonary bypass.Methods: A total of 126 patients were included in the study: 64 patients who underwent normothermic (35–37 °C) CPB and 62 patients who underwent hypothermic (28–34 °C) CPB. Statistical analyses were performed using SPSS 25.0 and Python software, with p</p></abstract>
                                                                                                                                    <trans-abstract xml:lang="tr">
                            <p>Amaç: Bu çalışmanın amacı, hipotermik ve normotermik kardiyopulmoner bypass uygulanan koroner arter bypass greftleme hastalarında metabolik ve hemodinamik parametrelerin zaman içerisindeki değişimini incelemektir.Materyal ve Metot: Çalışmaya, normotermik (35–37 °C) KPB uygulanan 64 ve hipotermik (28–34 °C) KPB uygulanan 62 olmak üzere toplam 126 hasta dahil edilmiştir. İstatistiksel analizlerde SPSS 25.0 ve Python yazılımı kullanılmış, p</p></trans-abstract>
                                                            
            
                                                            <kwd-group>
                                                    <kwd>Cardiopulmonary bypass</kwd>
                                                    <kwd>  Normothermia</kwd>
                                                    <kwd>  Hypothermia</kwd>
                                                    <kwd>  Metabolic parameters</kwd>
                                                    <kwd>  Systemic inflammation</kwd>
                                            </kwd-group>
                                                        
                                                                            <kwd-group xml:lang="tr">
                                                    <kwd>Kardiyopulmoner bypass</kwd>
                                                    <kwd>  Normotermi</kwd>
                                                    <kwd>  Hipotermi</kwd>
                                                    <kwd>  Metabolik parametreler</kwd>
                                                    <kwd>  Sistemik inflamasyon</kwd>
                                            </kwd-group>
                                                                                                        <funding-group specific-use="FundRef">
                    <award-group>
                                                    <funding-source>
                                <named-content content-type="funder_name">Harran Unıversity</named-content>
                            </funding-source>
                                                                    </award-group>
                </funding-group>
                                </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">1.Ralapanawa U, &amp; Sivakanesan, R. Epidemiology and the Magnitude of Coronary Artery Disease and Acute Coronary Syndrome: A Narrative Review. Journal of Epidemiology and Global Health, 2021;11:169 - 177. [Crossref]</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">2.Hendriks KDW, Castela Forte JN, Kok WF, Mungroop HE, Bouma HR, Scheeren TWL, et al. Mild hypothermia during cardiopulmonary bypass assisted CABG is associated with improved short- and long-term survival, a 18-year cohort study. PLoS One. 2022; 25;17(8):e0273370. [Crossref]</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">3.Stern M, Kok WF, Doorduin J, Jongman RM, Jainandunsing J, Nieuwenhuijs-Moeke GJ, et al. Mild and deep hypothermia differentially affect cerebral neuroinflammatory and cold shock response following cardiopulmonary bypass in rat. Brain Behav Immun. 2024;119:96-104. [Crossref]</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">4.Amer GF, Elawady MS, ElDerie A, Sanad M. Normothermia versus Hypothermia during Cardiopulmonary Bypass in Cases of Repair of Atrioventricular Septal Defect. Anesth Essays Res. 2020;14(1):112-118. [Crossref]</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">5.Bianco V, Kilic A, Aranda-Michel E, Dunn-Lewis C, Serna-Gallegos D, Chen S, et al. Mild hypothermia versus normothermia in patients undergoing cardiac surgery. JTCVS Open. 2021 (17);7:230-242. [Crossref]</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">6.Helman SM, Sereika S, Hravnak M, Henker R, Gaynor JW, Herrup E, et al. Association Between Persistent Hypothermia After Cardiopulmonary Bypass in Neonates and Odds of Serious Complications. Crit Care Explor. 2024;20;6(8):e1137. [Crossref]</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">7.Keizman E, Mishaly D, Ram E, Urtaev S, Tejman-Yarden S, Tirosh Wagner T, et al. Normothermic Versus Hypothermic Norwood Procedure. World J Pediatr Congenit Heart Surg. 2023;14(2):125-132. [Crossref]</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">8.Dankiewicz J, Cronberg T, Lilja G, Jakobsen JC, Levin H, Ullén S, et al. TTM2 Trial Investigators. Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest. N Engl J Med. 2021;17;384(24):2283-2294.</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">9.Enayet K, Hussain M, Islam M, Karim T, Jahan T, Das P, et al. Serum Albumin and Its Influence on Immediate Outcomes in Children with Congenital Heart Disease Undergoing Cardiac Surgery. Bangladesh Heart Journal. 2024;75794. [Crossref]</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">10.Karki S, Gajjar R, Bittar-Carlini G, Jha V, Yadav N. Association of Hypoalbuminemia With Clinical Outcomes in Patients Admitted With Acute Heart Failure. Curr Probl Cardiol. 2023;48(11):101916. [Crossref]</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">11.Martin KR, Gamell C, Tai TY, Bonelli R, Hansen J, Tatoulis J, et al. Whole blood transcriptomics reveals granulocyte colony-stimulating factor as a mediator of cardiopulmonary bypass-induced systemic inflammatory response syndrome. Clin Transl Immunology. 2024;19;13(2):e1490. [Crossref]</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">12.Reddy D, Sunitha Y, Thangavel D, Ramkumar J &amp; Miller, S. Effects of cardiopulmonary bypass on liver function in patients undergoing cardiac surgery. CARDIOMETRY. [Crossref]</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">13.Kumar R, Bansal M, Nath SS, Kumar V, Malviya D, Srivastava D. N-Acetylcysteine Supplementation for the Prevention of Postoperative Liver Dysfunction after On-Pump Cardiac Surgery. Turk J Anaesthesiol Reanim. 2021;49(6):460-469. [Crossref]</mixed-citation>
                    </ref>
                                    <ref id="ref14">
                        <label>14</label>
                        <mixed-citation publication-type="journal">14.Zakkar M, Amirak E &amp; Bryan AJ. The effects of cardiopulmonary bypass on the liver: a review. Eur J Cardiothorac Surg, 2014;45(4): 661-667.</mixed-citation>
                    </ref>
                                    <ref id="ref15">
                        <label>15</label>
                        <mixed-citation publication-type="journal">15.Sabzi F, Faraji R. Liver Function Tests Following Open Cardiac Surgery. J Cardiovasc Thorac Res. 2015;7(2):49-54. [Crossref]</mixed-citation>
                    </ref>
                                    <ref id="ref16">
                        <label>16</label>
                        <mixed-citation publication-type="journal">16.Deininger S, Hoenicka M, Müller-Eising K, Rupp P, Liebold A, Koenig W, et al. Renal Function and Urinary Biomarkers in Cardiac Bypass Surgery: A Prospective Randomized Trial Comparing Three Surgical Techniques. Thorac Cardiovasc Surg. 2016;64(7):561-568. [Crossref]</mixed-citation>
                    </ref>
                                    <ref id="ref17">
                        <label>17</label>
                        <mixed-citation publication-type="journal">17.Leong XF, Cheng M, Jong B, Hwang NC, Roscoe A. Sodium Abnormalities in Cardiac Surgery With Cardiopulmonary Bypass in Adults: A Narrative Review. J Cardiothorac Vasc Anesth. 2021;35(11):3374-3384. [Crossref]</mixed-citation>
                    </ref>
                                    <ref id="ref18">
                        <label>18</label>
                        <mixed-citation publication-type="journal">18.He Y, Liu S, Luo Y, Wu H, Yu Y &amp; Chen, H. Elevation of C-reactive protein early after cardiopulmonary bypass surgery is associated with occurrence of postoperative atrial fibrillation. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022;42 (3): 443-447.</mixed-citation>
                    </ref>
                                    <ref id="ref19">
                        <label>19</label>
                        <mixed-citation publication-type="journal">19.Milam AJ, Liang C, Mi J, Mascha EJ, Halvorson S, Yan M, et al. Derivation and Validation of Clinical Phenotypes of the Cardiopulmonary Bypass-Induced Inflammatory Response. Anesth Analg. 2023;1;136(3):507-517. [Crossref]</mixed-citation>
                    </ref>
                                    <ref id="ref20">
                        <label>20</label>
                        <mixed-citation publication-type="journal">20.Li S, Nordick KV, Murrieta-Álvarez I, Kirby RP, Bhattacharya R, Garcia I, et al. Prolonged Cardiopulmonary Bypass Time-Induced Endothelial Dysfunction via Glypican-1 Shedding, Inflammation, and Matrix Metalloproteinase 9 in Patients Undergoing Cardiac Surgery. Biomedicines. 2024;27;13(1):33. [Crossref]</mixed-citation>
                    </ref>
                                    <ref id="ref21">
                        <label>21</label>
                        <mixed-citation publication-type="journal">21.Ghasemzade B, Ghodrati M, Kachuian N, Banakar Y, Gorjipour F, Zarei A, &amp; Zaree, H. Fibrinogen and Fibrin Degradation Products&#039; Levels in Cardiopulmonary Bypass with Mild-Hypothermia versus Normothermia. 2020;V5I3.30324.</mixed-citation>
                    </ref>
                                    <ref id="ref22">
                        <label>22</label>
                        <mixed-citation publication-type="journal">22.Linassi F, Maran E, De Laurenzis A, Tellaroli P, Kreuzer M, Schneider G, et al. Targeted temperature management in cardiac surgery: a systematic review and meta-analysis on postoperative cognitive outcomes. Br J Anaesth. 2022;128(1):11-25. [Crossref]</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
