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Year 2018, Volume: 3 Issue: 2, 71 - 74, 01.06.2018
https://doi.org/10.5281/zenodo.2553565

Abstract

References

  • Pandey et al, 2000 Pandey, Devendra; Kumar, Ajendra; Nag, AK (2000). Asian Journal of Chemistry, 12, 1361
  • Qu et al, 2015 Qu, Dan; Niu, Fang; Zhao, Xinlu; Yan, Ke-Xiang; Ye, Yu-Ting; Wang, Jia; Zhang, Mei; You, Zhonglu (2015). Bioorganic & medicinal chemistry, 23, 1944-1949
  • Scavenging, 2015 Scavenging, DPPH Radical (2015). J. Chem. Soc. Pak, 37, 479
  • Shakir et al, 2015 Shakir, M; Abbasi, A (2015). Journal of Chemical and Pharmaceutical Research, 7, 375-382
  • Tan et al, 2013 Tan, Lirong; Su, Jiyan; Wu, Dianwei; Yu, Xiaodan; Su, Zuqing; He, Jingjin; Wu, Xiaoli; Kong, Songzhi; Lai, Xiaoping; Lin, Ji; others (2013). The ScientiŞc World Journal, 2013
  • Verma et al, 2014 Verma, Garima; Marella, Akranth; Shaquiquzzaman, Mohammad; Akhtar, Mymoona; Ali, Mohammad Rahmat; Alam, Mohammad Mumtaz (2014). Journal of pharmacy & bioallied sciences, 6, 69

SYNTHESIS AND CHARACTERIZATION OF SOME NEW HYDRAZONES WITH ANTI‐UREASE ACTIVITIES

Year 2018, Volume: 3 Issue: 2, 71 - 74, 01.06.2018
https://doi.org/10.5281/zenodo.2553565

Abstract

Hydrazones were considered as signiŞcant substrates in drug discovery process. Therefore, a seriesof some new 1- 4- 1- 2- 4-substitutedphenyl hydrazono ethyl phenyl -3- 4-nitrophenyl ureaderivatives were synthesized as potential urease inhibitory agents. The synthesizedcompounds were characterized by FTIR, ¹H NMR, 13C NMR, and elemental analysis C, H, N . Allcompounds were evaluated in vitro for urease inhibitory potential. Among synthesized compounds,8, 7, 6, and 4 showed excellent activities IC50 i.e. 10.13±0.40, 12.15±0.22, 17.81±0.36, and22.95±0.47 µM, respectively. This study has culminated in the identiŞcation of some compoundswhich can serve as leads for new potent urease inhibitors

References

  • Pandey et al, 2000 Pandey, Devendra; Kumar, Ajendra; Nag, AK (2000). Asian Journal of Chemistry, 12, 1361
  • Qu et al, 2015 Qu, Dan; Niu, Fang; Zhao, Xinlu; Yan, Ke-Xiang; Ye, Yu-Ting; Wang, Jia; Zhang, Mei; You, Zhonglu (2015). Bioorganic & medicinal chemistry, 23, 1944-1949
  • Scavenging, 2015 Scavenging, DPPH Radical (2015). J. Chem. Soc. Pak, 37, 479
  • Shakir et al, 2015 Shakir, M; Abbasi, A (2015). Journal of Chemical and Pharmaceutical Research, 7, 375-382
  • Tan et al, 2013 Tan, Lirong; Su, Jiyan; Wu, Dianwei; Yu, Xiaodan; Su, Zuqing; He, Jingjin; Wu, Xiaoli; Kong, Songzhi; Lai, Xiaoping; Lin, Ji; others (2013). The ScientiŞc World Journal, 2013
  • Verma et al, 2014 Verma, Garima; Marella, Akranth; Shaquiquzzaman, Mohammad; Akhtar, Mymoona; Ali, Mohammad Rahmat; Alam, Mohammad Mumtaz (2014). Journal of pharmacy & bioallied sciences, 6, 69
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Details

Primary Language English
Journal Section Research Article
Authors

Yusuf Sıcak This is me

Publication Date June 1, 2018
Published in Issue Year 2018 Volume: 3 Issue: 2

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