The Potential Antiviral Activity of Inositol (Vitamin B8) as a Dietary Supplement in Human and Animal Nutrition
Yıl 2022,
Cilt: 2 Sayı: 3, 68 - 72, 30.09.2022
Serol Korkmaz
,
Ahmet Sait
,
Ayşen Gargılı
Öz
Inositol is categorized as an essential vitamin and recognised as a B8 vitamin. It and its derivatives including myo-inositol has some biological activity in several metabolisms. inositol is well tolerated and a natural constituent in human and animal nutrition. The toxicity of inositol is low. At the various concentrations, it presented antiviral activity against serious viruses such as rhinovirus, coxsackie, herpesvirus, HIV and iridovirus threatening biosafety, human and animal health. This review aimed to present the structure, role in nutrition, toxicity and potential antiviral activities of inositol and its derivatives as a dietary supplement in human and animal nutrition with One-Health concept.
Destekleyen Kurum
Marmara Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi
Proje Numarası
TYL-2022-10463
Teşekkür
This work has been supported by Marmara University Scientific Research Projects Coordination Unit under grant number TYL-2022-10463.
Kaynakça
- [1] Baranova EO, Shastina NS, Lobach OA, Chataeva MS, Nosik DN, Shvets VI. Activity of the inositol-containing phospholipid dimer analogues against human immunodeficiency virus. Vopr Virusol. 2014;59(1):34—38. http://europepmc.org/abstract/MED/25065144
- [2] Bezerra Espinola MS, Bertelli M, Bizzarri M, et al. Inositol and vitamin D may naturally protect human reproduction and women undergoing assisted reproduction from Covid-19 risk. J Reprod Immunol. 2021;144:103271. doi:10.1016/J.JRI.2021.103271
- [3] Coppey LJ, Gellett JS, Davidson EP, Dunlap JA, Yorek MA. Effect of treating streptozotocin-induced diabetic rats with sorbinil, myo-inositol or aminoguanidine on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve. Int J Exp Diabetes Res. 2002;3(1):21-36. doi:10.1080/15604280212525
- [4] EFSA. Scientific Opinion on the safety and efficacy of inositol as a feed additive for fish, dogs and cats. EFSA J. 2014;12(5). doi:10.2903/J.EFSA.2014.3671
- [5] European Commission. Register of Feed Additives, 226th Edition.; 2016. doi:10.2875/434313
- [6] FDA. Nutrient information. Subchapter b, food for human consumption. Code of Federal Regulations (CFR). Published 2022. Accessed June 20, 2022. https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-107/subpart-B/section-107.10
- [7] Liu M, Yu Q, Yi Y, et al. Antiviral activities of Lonicera japonica Thunb. Components against grouper iridovirus in vitro and in vivo. Aquaculture. 2020;519(September 2019). doi:10.1016/j.aquaculture.2019.734882
- [8] Lüscher-Mattli M. Polyanions - A lost chance in the fight against HIV and other virus diseases? Antivir Chem Chemother. 2000;11(4):249-259. doi:10.1177/095632020001100401
- [9] Ni J, Singh S, Wang LX. Improved preparation of perallylated cyclodextrins: facile synthesis of cyclodextrin-based polycationic and polyanionic compounds. Carbohydr Res. 2002;337(3):217-220. doi:10.1016/S0008-6215(01)00303-2
- [10] Official Gazette. Türk gıda kodeksi bebek formülleri ve devam formülleri tebliği (No: 2019/14). TR Official Gazette 30819. Published 2019. Accessed June 20, 2022. https://www.resmigazete.gov.tr/fihrist?tarih=2019-07-02
- [11] Official Gazette. Türk gıda kodeksi bebek ve küçük çocuklara yönelik gıdalar ile vücut ağırlığı kontrolü için diyetin yerini alan gıdalar yönetmeliği. TR Official Gazette 30819. Published 2019. Accessed June 20, 2022. https://www.resmigazete.gov.tr/fihrist?tarih=2019-07-02
- [12] Official Gazette. Türk gida kodeksi enerji içecekleri tebliği (2017/4). TR Offical Gazette 30110. Published 2017. Accessed June 20, 2022. https://www.resmigazete.gov.tr/eskiler/2017/06/20170930-23.htm
- [13] Official Gazette. Türk Gıda Kodeksi Vücut Ağırlığı Kontrolü İçin Diyetin Yerini Alan Gıdalar Tebliği (No: 2019/15). TR Official Gazette 30819. Published 2019. Accessed June 20, 2022. https://www.resmigazete.gov.tr/fihrist?tarih=2019-07-02
- [14] Otake T, Shimonaka H, Kanai M, et al. Inhibitory effect of inositol hexasulfate and inositol hexaphosphoric acid (phytic acid) on the proliferation of the human immunodeficiency virus (HIV) in vitro. J Japanese Assoc Infect Dis. 1989;63(7):676-683. doi:10.11150/KANSENSHOGAKUZASSHI1970.63.676
- [15] Pugliese G, Tilton RG, Speedy A, et al. Modulation of hemodynamic and vascular filtration changes in diabetic rats by dietary myo-inositol. Diabetes. 1990;39(3):312-322. doi:10.2337/DIAB.39.3.312
- [16] Tilton RG, Faller AM, LaRose LS, Burgan J, Williamson JR. Dietary myo-inositol supplementation does not prevent retinal and glomerular vascular structural changes in chronically diabetic rats. J Diabetes Complications. 1993;7(3):188-198. doi:10.1016/1056-8727(93)90044-Y
- [17] Tuchnaya OA, Gorlachuk O V., Livshits VA, et al. Synthesis of anionic derivatives of myo-inositol and other polyols and investigation of their antiviral activity. Pharm Chem J 2008 421. 2008;42(1):4-10. doi:10.1007/S11094-008-0045-6
- [18] Webb SJ, Bather R, Hodges RW. The effect of relative humidity and inositol on air-borne viruses. Can J Microbiol. 1963;9(1):87-92. doi:10.1139/M63-009
- [19] Zhan TR, Ma YD, Fan PH, Ji M, Lou HX. Synthesis of 4/5-Deoxy-4/5-nucleobase Derivatives of 3-O-Methyl-D-chiro-inositol as Potential Antiviral Agents. Chem Biodivers. 2006;3(10):1126-1137. doi:10.1002/CBDV.200690114
İnsan ve hayvan beslenmesinde besin takviyesi olarak kullanılan İnositol’ün (vitamin B8) potansiyel antviral etkileri
Yıl 2022,
Cilt: 2 Sayı: 3, 68 - 72, 30.09.2022
Serol Korkmaz
,
Ahmet Sait
,
Ayşen Gargılı
Öz
İnositol B8 virtamini olarak esansiyel vitamin olarak kabul edilmektedir. Inositol ve myo-inositol gibi türevleri çeşitli metabolizmalarda biyolojik aktiviteye sahiptir. İnositol iyi tolere edilir. İnsan ve hayvan beslenmesinde doğal bir bileşendir. İnositol düşük toksisiteye sahiptir. Çeşitli konsantrasyonlarda, rinovirüs, coxsackie, herpesvirus, HIV ve iridovirus gibi biyogüvenliği, insan ve hayvan sağlığını tehdit eden ciddi virüslere karşı antiviral aktiviteye sahip olduğu bildirilmiştir. Bu derleme ile insan ve hayvan beslenmesinde takviye olarak kullanılan inositol ve türevlerinin yapısını, beslenmedeki rolünü, toksisitesini ve potansiyel antiviral aktivitelerini Tek-Sağlık konsepti ile sunmak amaçlanmıştır.
Proje Numarası
TYL-2022-10463
Kaynakça
- [1] Baranova EO, Shastina NS, Lobach OA, Chataeva MS, Nosik DN, Shvets VI. Activity of the inositol-containing phospholipid dimer analogues against human immunodeficiency virus. Vopr Virusol. 2014;59(1):34—38. http://europepmc.org/abstract/MED/25065144
- [2] Bezerra Espinola MS, Bertelli M, Bizzarri M, et al. Inositol and vitamin D may naturally protect human reproduction and women undergoing assisted reproduction from Covid-19 risk. J Reprod Immunol. 2021;144:103271. doi:10.1016/J.JRI.2021.103271
- [3] Coppey LJ, Gellett JS, Davidson EP, Dunlap JA, Yorek MA. Effect of treating streptozotocin-induced diabetic rats with sorbinil, myo-inositol or aminoguanidine on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve. Int J Exp Diabetes Res. 2002;3(1):21-36. doi:10.1080/15604280212525
- [4] EFSA. Scientific Opinion on the safety and efficacy of inositol as a feed additive for fish, dogs and cats. EFSA J. 2014;12(5). doi:10.2903/J.EFSA.2014.3671
- [5] European Commission. Register of Feed Additives, 226th Edition.; 2016. doi:10.2875/434313
- [6] FDA. Nutrient information. Subchapter b, food for human consumption. Code of Federal Regulations (CFR). Published 2022. Accessed June 20, 2022. https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-107/subpart-B/section-107.10
- [7] Liu M, Yu Q, Yi Y, et al. Antiviral activities of Lonicera japonica Thunb. Components against grouper iridovirus in vitro and in vivo. Aquaculture. 2020;519(September 2019). doi:10.1016/j.aquaculture.2019.734882
- [8] Lüscher-Mattli M. Polyanions - A lost chance in the fight against HIV and other virus diseases? Antivir Chem Chemother. 2000;11(4):249-259. doi:10.1177/095632020001100401
- [9] Ni J, Singh S, Wang LX. Improved preparation of perallylated cyclodextrins: facile synthesis of cyclodextrin-based polycationic and polyanionic compounds. Carbohydr Res. 2002;337(3):217-220. doi:10.1016/S0008-6215(01)00303-2
- [10] Official Gazette. Türk gıda kodeksi bebek formülleri ve devam formülleri tebliği (No: 2019/14). TR Official Gazette 30819. Published 2019. Accessed June 20, 2022. https://www.resmigazete.gov.tr/fihrist?tarih=2019-07-02
- [11] Official Gazette. Türk gıda kodeksi bebek ve küçük çocuklara yönelik gıdalar ile vücut ağırlığı kontrolü için diyetin yerini alan gıdalar yönetmeliği. TR Official Gazette 30819. Published 2019. Accessed June 20, 2022. https://www.resmigazete.gov.tr/fihrist?tarih=2019-07-02
- [12] Official Gazette. Türk gida kodeksi enerji içecekleri tebliği (2017/4). TR Offical Gazette 30110. Published 2017. Accessed June 20, 2022. https://www.resmigazete.gov.tr/eskiler/2017/06/20170930-23.htm
- [13] Official Gazette. Türk Gıda Kodeksi Vücut Ağırlığı Kontrolü İçin Diyetin Yerini Alan Gıdalar Tebliği (No: 2019/15). TR Official Gazette 30819. Published 2019. Accessed June 20, 2022. https://www.resmigazete.gov.tr/fihrist?tarih=2019-07-02
- [14] Otake T, Shimonaka H, Kanai M, et al. Inhibitory effect of inositol hexasulfate and inositol hexaphosphoric acid (phytic acid) on the proliferation of the human immunodeficiency virus (HIV) in vitro. J Japanese Assoc Infect Dis. 1989;63(7):676-683. doi:10.11150/KANSENSHOGAKUZASSHI1970.63.676
- [15] Pugliese G, Tilton RG, Speedy A, et al. Modulation of hemodynamic and vascular filtration changes in diabetic rats by dietary myo-inositol. Diabetes. 1990;39(3):312-322. doi:10.2337/DIAB.39.3.312
- [16] Tilton RG, Faller AM, LaRose LS, Burgan J, Williamson JR. Dietary myo-inositol supplementation does not prevent retinal and glomerular vascular structural changes in chronically diabetic rats. J Diabetes Complications. 1993;7(3):188-198. doi:10.1016/1056-8727(93)90044-Y
- [17] Tuchnaya OA, Gorlachuk O V., Livshits VA, et al. Synthesis of anionic derivatives of myo-inositol and other polyols and investigation of their antiviral activity. Pharm Chem J 2008 421. 2008;42(1):4-10. doi:10.1007/S11094-008-0045-6
- [18] Webb SJ, Bather R, Hodges RW. The effect of relative humidity and inositol on air-borne viruses. Can J Microbiol. 1963;9(1):87-92. doi:10.1139/M63-009
- [19] Zhan TR, Ma YD, Fan PH, Ji M, Lou HX. Synthesis of 4/5-Deoxy-4/5-nucleobase Derivatives of 3-O-Methyl-D-chiro-inositol as Potential Antiviral Agents. Chem Biodivers. 2006;3(10):1126-1137. doi:10.1002/CBDV.200690114