Early Effects of Breast Cancer Chemotherapy by Fluorouracil, Epirubicin and Cyclophosphamide with or without Docetaxel Regimen on the Right and Left Ventricle Functions

Year 2015, Volume: 1 Issue: 1, 6 - 12, 01.03.2015

Cemil Bilir Hüseyin Engin Turgut Karabag Derya Demirtas Orhan Demirtas

Abstract

Amaç: Meme kanseri tedavisi Fluorouracil, Epirubicin and Cyclophosphamide (FEC) VEFEC-Docetaxel ile yapılan anjuvan
protokolü sırasında global kardiyak fonksiyon durumunun incelenmesi.
Gereç ve Yöntem: Onkoloji bölümünde meme kanseri nedeniyle adjuvant tedavi gören 51 hasta çalışmaya alındı.
Bulgular: Tedavi başlangıcı ile karşılaştırıldığında 6 aylık tedavi sonrası LVEF 66%±3 den 64.5%±4.4 e düştü, p=0.001. 6
aylık takipte Sol Ventriküler MPI değerleri bazal değerler olan 0.45±0.1 dan 0.58±0.15 e yükseldi, p=0.0001. Tedavi öncesi
ve sonrası ortalama TAPSE değerleri sırasıyla 2.45±0.42 ve 2.05±0.35 cm, p=0.0001 idi. Altı aylık tedavi sonrasında, bazal
ölçümlerler kıyaslandığında Sağ Ventriküler TDI MPI değerlerinde tedavi sonrası anlamlı artış saptandı (0.23 ve 0.37,
p=0.0001). Yalnızca FEC ve Docetaxel fonrası FEC rejimlerine ait tedavi öncesi ve sonrası LVEF, LV MPI, TAPSE ve RV TDI
MPI ölçümlerinin Delta değerleri karşılaştırıldığında, anlamlı bir değişiklik saptanmadı (sırasıyla p= 0.08, p=0.38, p=0.43
and p=0.2).
Sonuç: TAPSE, LVD TDI MPI ve RD TDI MPI ile değerlendirildiğinde, FEC kemoterapisi subklinik Sağ Ventrikül
disfonksiyonuyla ilişkilidir. 

Keywords

Kemoterapi, FEC-Docetaxel rejimi, Ekokardiografi, TAPSE, tei index

Early Effects of Breast Cancer Chemotherapy by Fluorouracil, Epirubicin and Cyclophosphamide with or without Docetaxel Regimen on the Right and Left Ventricle Functions

Abstract

Objectives: to investigate global cardiac functional status during adjuvant chemotherapy with Fluorouracil, Epirubicin and
Cyclophosphamide (FEC) and FEC-Docetaxel protocol for breast cancer.
Material and Method: 51 women treated with adjuvant chemotherapy for breast cancer at the oncology department.
Results: LVEF decreased from baseline values of 66%±3 to 64.5%±4.4, p=0.001 at six month calculations as compared to
the beginning. There was increase in the Left Ventricular MPI values from the baseline records of 0.45±0.1 to 0.58±0.15,
p=0.0001 at six months follow-up. Mean TAPSE values were 2.45±0.42 and 2.05±0.35 cm respectively, p=0.0001. There
was increase in the right ventricular TDI MPI values after the therapy as compared to the baseline calculations (0.23 and
0.37, p=0.0001) at six months. When we compare the delta values of LEVF, LV MPI, TAPSE and RV TDI MPI in group
of FEC alone and FEC followed by Docetaxel regimen, we did not fi nd any signifi cant changes before and after the
chemotherapy (p= 0.08, p=0.38, p=0.43 and p=0.2, respectively).
Conclusion: Chemotherapy with FEC is associated with subclinical right and left ventricular dysfunction as assessed
by TAPSE, left ventricular Doppler myocardial performance index, and right ventricular tissue Doppler myocardial
performance index. 

Keywords

Chemotherapy, FEC-Docetaxel regimen, Echocardiography, TAPSE, tei index

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