DISTRIBUTION OF SELENOPROTEIN W1 (rs3786777) GENOTYPES IN TURKISH PREECLAMPTIC WOMEN

Year 2017, Volume: 3 Issue: 1, 68 - 73, 30.03.2017

Elif Erdoğan Fatma Bahice Cinemre Hakan Cinemre Abdullah Tüten Nevin Yılmaz Barış Kaya Birsen Aydemir

Abstract

Objective: Preeclampsia is characterized by hypertension,
proteinuria and edema during pregnancy, It causes. intrauterine growth
retardation, premature birth, fetal and maternal mortality. The selenium takes
place in the structure of selenoproteins which are mostly showing
oxidoreductase activity in human. Some studies were reported that selenoproteins
W (SelW) plays an important role as an antioxidant in the developing brain and
embryo. SelW expression level in the fetal muscle and heart tissue depends on fetal
selenium levels. SelW function is not completely elucidated yet. The purpose of this study was to determine whether common variation in
selenoprotein W1 (SEPW1) alters the risk of preeclampsia (PE).

 

Materials and Methods: 82 pregnant women with PE and 85 healthy pregnant women
from the same geographic region were included in the study. Allele-specific Polymerase Chain Reaction (ASPCR) analysis
was used to identify polymorphism
of the SEPW1 gene (rs3786777).

 

Results: Serum lipids, total protein and albumin levels were
measured in all cases. We found that fetal weight, total protein and albumin
levels significantly decreased in preeclamptic pregnancies compared to healthy
pregnant (p=0.001, for each).  Systolic
and diastolic blood pressure, body mass index, total cholesterol and
triglyceride levels were significantly increased in preeclamptic patients when
compared to healthy control group (p=0.001, p=0.001, p=0.001, p=0.05, p=0.01,
respectively). The frequencies of the CC, CA and AA genotypes were found as 23
%, 67 % and 10 % in pregnant women with PE and 27 %, 57 % and 16 % in healthy
pregnant women, respectively. Our results indicated that the distribution of
the SEPW1 genotypes and alleles did not
differ significantly among subjects with or without PE (p>0.05).

 

Conclusions: In some study SelW is associated with fetal development, so we thought
that its gene distribution may be involved in the occurrence of preeclampsia or
its complication. SEPW1 polymorphism
did not alter the risk of PE in our population. However, clarification
by further studies in larger populations is needed. SEPW1 (rs3786777)
polymorphism has no role in etiopathogenesis of preeclamptic Turkish women.

Keywords

Preeclampsia; Selenoprotein W1 gene; Polymorphism

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