The relationship between myocardial viability and plasma NT-proBNP levels

Year 2019, Volume: 5 Issue: 3, 246 - 255, 01.09.2019

Kudret Keskin

Abstract

Aim: There is no biochemical marker
that indicates myocardial viability in the late phase after myocardial
infarction. The aim of our study was to identify whether plasma NT-proBNP
levels indicate the presence of viable myocardium after myocardial infarction.

Material and Methods: Patients with
myocardial infarction and left ventricular ejection fraction of less than 45%
were included in the study. Exercise or pharmacological myocardial perfusion
scintigraphy was performed to investigate viability in the infarction region.
The left ventricle was divided into 19 segments where the necrotic area and
viable myocardium within it was measured. Blood samples for NT-proBNP
measurement were obtained from all patients on the same day scintigraphy
performed.

Results: A total of 60 patients
were included in the study (10 females, 50 males, mean age 62 ± 9 years). 48
(80%) patients underwent exercise scintigraphy. The mean exercise time was 7.1
± 2.3 minutes. The infarct area was located in anterior segments in 16
patients, inferior in 25, and in both locations in 19 patients. The mean left
ventricular ejection fraction was 36 ± 8%. There was a negative correlation
between left ventricular ejection fraction and serum NT-proBNP levels (r =
-0.03 p <0.01). On the other hand, there was no correlation between plasma
NT-proBNP levels and the presence or extent of viable myocardium within the
necrotic area (P = 0.8).

Conclusion: There was no correlation between
plasma NT-proBNP levels and the presence of viable myocardium in the infarct zone
in patients with myocardial infarction

Keywords

myocardial infarction, viable myocardium, NT-proBNP

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