The efficacy of new treatment methods in HCV patients: a single center study

Year 2019, Volume: 5 Issue: 3, 283 - 293, 01.09.2019

Derya Demirtas

Abstract

ABSTRACT

Aim:
Achieving sustained virologic response (SVR) is critical in patients with
chronic hepatitis C virus (HCV) infection. Over the last few years, many developments
have been made in HCV infection treatment with the evaluation of direct-actinga
antivirals (DAAs). Treatment with DAAs resulted in high rates of SVR among
patients with chronic HCV infection.  
The aim of our study aim to compare the treatment efficacy between
different DAA regimens in patients with HCV.

Methods:
In our study 290 patients were evaluated retrospectively with regard to the
effects related to the use of DAAs and its effects on HCV-RNA. The primary end
point was a SVR at 12 weeks after the end of the DAA therapy.

Results:
In our study included 290 patients who were treated with DAA. The rate of SVR
was 99% (98%; 95 confidence interval [CI], 96 to 100) with 12 weeks of
ledipasvir plus sofosbuvir (LDV+SOF), 96% (97.9%; 95% CI, 94 to 99) with 12
weeks of sofosbuvir plus ribavirin (SOF+RBV), and 90% (98.9%; 95% CI, 95 to 99)
with 12 weeks of ombitasvir/paritaprevir/ritonavir plus dasabuvir (PrOD). In
comparing LDV+SOF, SOF+RBV and PrOD, the chance of having SVR between these
three DAA regimens was not significantly different.

Conclusion:
DAA treatment regimens should be preferred in the first line drug for the
treatment of chronic HCV infection because of the their significant clinical
benefits.

Keywords

Chronic Hepatitis C, direct-acting antiviral

References

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