Preparation and Anticancer Activities of Some Amino Acid Methyl Ester Schiff Bases

Nilay Akkuş Taş; Ayşegül Şenocak; Ali Aydın

doi:10.18596/jotcsa.373904

Research Article

Preparation and Anticancer Activities of Some Amino Acid Methyl Ester Schiff Bases

Year 2018, Volume: 5 Issue: 2, 585 - 606, 01.01.2018

Nilay Akkuş Taş Ayşegül Şenocak , Ali Aydın

https://doi.org/10.18596/jotcsa.373904

Cited By: 6

An Erratum to this article was published on February 4, 2024. https://dergipark.org.tr/en/pub/jotcsa/issue/80874/1418327

Abstract

In this study, we prepared nine Schiff bases by
condensation of amino acid methyl esters (isoleucine, phenylalanine and
methionine) with salicylaldehyde derivatives (2,4-dihydroxybenzaldehyde,
2-hydroxy-3-methoxybenzaldehyde and 5-bromo-2-hydroxybenzaldehyde) and
characterized by various spectroscopic methods (FT-IR, UV-Vis and NMR techniques).
FT-IR and UV-Vis spectra exhibited characteristic peaks for all imine
compounds. NMR spectra pointed out the imine bond which is the indicator of the
formation of Schiff bases. Besides, antiproliferative and cytotoxic features of
the Schiff bases were examined by using MTT cell proliferation and LDH
cytotoxicity assays, respectively. Amongst the synthesized Schiff bases, compound
3d exhibited a very strong
antiproliferative effect against all cells except A549. The experimental studies
revealed that the Schiff bases synthesized in this study, especially 3d, have an important potential to
enter drug development studies.

Keywords

Amino acid Schiff base, salicylaldehyde, antiproliferative activity, cytotoxicity, anticancer activity

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