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Year 2018, Volume: 5 Issue: 3, 1043 - 1050, 01.09.2018
https://doi.org/10.18596/jotcsa.308895

Abstract

References

  • 1. World Cancer Report 2014. http://www.iarc.fr/en/publications/books/wcr/wcr-order.php (accessed 15.09.16).
  • 2. Elgorashi E. Screening of medicinal plants used in South African traditional medicine for genotoxic effects. Toxicol. Lett. 2003; 143, 195–207. doi:10.1016/S0378-4274(03)00176-0.
  • 3. Fennell CW, Lindsey KL, McGaw LJ, Sparg SG, Stafford GI, Elgorashi EE, Grace OM, van Staden J. Assessing African medicinal plants for efficacy and safety: pharmacological screening and toxicology. J. Ethnopharmacol. 2004; 94, 205–217.
  • 4. Sithranga Boopathy N, Kathiresan K. Anticancer Drugs from Marine Flora: An Overview. J. Oncol. 2010; 1–18. doi:10.1155/2010/214186.
  • 5. Weerapreeyakul N, Nonpunya A, Barusrux S, Thitimetharoch T, Sripanidkulchai B. Evaluation of the anticancer potential of six herbs against a hepatoma cell line Chin. Med. 2012; 7, 15.
  • 6. Lee CC, Houghton P. Cytotoxicity of plants from Malaysia and Thailand used traditionally to treat cancer. J. Ethnopharmacol. 2005; 100, 237–243.
  • 7. Berrington D, Lall N. Anticancer Activity of Certain Herbs and Spices on the Cervical Epithelial Carcinoma (HeLa) Cell Line. Evidence-Based Complement. Altern. Med. 2012; 1–11.
  • 8. Itharat A, Houghton PJ, Eno-Amooquaye E, Burke P, Sampson JH, Raman A. In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer. J. Ethnopharmacol. 2004; 90, 33–38.
  • 9. Chinese Pharmacopoeia Commission. http://www.chp.org.cn/cms/home/ (accessed 15.09.16).
  • 10. Shun-Wan C, Ping L, Yiu-Wa K, Ge L. In vitro Tracheobronchial Relaxation of Fritillaria Alkaloids. Chinese Journal of Natural Medicines. 2011; 9(5), 0345−0353. doi: 10.3724/SP.J.1009.2011.00345
  • 11. Kiani M, Sefidkon F, Babaei A, Naghavi MR. Phytochemical profiling of medicinal isosteroidal alkaloids of Iranian Fritillaria spp. (Liliaceae). Ind. Crops Prod. 2015; 70, 451–458.
  • 12. Atta-Ur-RahmaN, Akhtar MN, Choudhary MI, Tsuda Y, Sener B, Khalid A, Parvez M. New steroidal alkaloids from Fritillaria imperialis and their cholinesterase inhibiting activities. Chem. Pharm. Bull. 2002; 50, 1013–6.
  • 13. HAO D-C, GU X-J, XIAO P-G, PENG Y. Phytochemical and biological research of Fritillaria Medicine Resources. Chin. J. Nat. Med. 2013; 11, 330–344.
  • 14. Türktaş M, Aslay M, Kaya E, Ertuğrul F. Molecular characterization of phylogeneticrelationships in Fritillaria species inferred from chloroplast trnL-trnF sequences. Turk J Biol. 2012; 36, 552-560. doi:10.3906/biy-1201-30
  • 15. Maharjan BL, Devkota HK, Baral B. In-vitro Antimicrobial Activity and Phytochemical Screening of Fritillaria delavayi. Nepal J. Sci. Technol. 2012; 12, 85-90.
  • 16. Erbil N, Alan Y, Digrak M. Antimicrobial Activity of Different Vegetative Parts of Tulipa sintenisii (Mus Lalesi) and Fritillaria imperialis (Aglayan Gelin). International Journal of Scientific and Technological Research. 2015; 1(2), 120-127.
  • 17. Gilani AH, Shaheen F, Christopoulos A, Mitchelson F. Interaction of ebeinone, an alkaloid from Fritillaria imperialis, at two muscarinic acetylcholine receptor subtypes. Life Sci. 1997; 60(8), 535–44.
  • 18. Akhtar MN, Atta-ur-Rahman, Choudhary MI, Sener B, Erdogan I, Y. Tsuda Y. New class of steroidal alkaloids from Fritillaria imperialis. Phytochemistry 2003; 63(1), 115–122.
  • 19. Aydın A, Erenler R, Yılmaz B, Tekin Ş. Antiproliferative effect of Cherry laurel. JOTCSA, 2016; 3(3), 217-228.doi:10.18596/jotcsa.21204.
  • 20. Güler DA, Aydın A, Koyuncu M, Parmaksız İ. Anticancer Activity of Papaver somniferum L. JOTCSA, 2016; 3(3), 349-366. doi: 10.18596/jotcsa.43273

Biological Property of Fritillaria imperialis L. Extract

Year 2018, Volume: 5 Issue: 3, 1043 - 1050, 01.09.2018
https://doi.org/10.18596/jotcsa.308895

Abstract

A preliminary in vitro screening revealed the therapeutic status of extracts of Fritillaria imperialis L. that belongs to the Liliaceae family. Its tendrilled bulbs are consumed fresh or prepared in a powdered form and used as a home remedy for cough and phlegm, high fever, hemorrhage, lack of milk, treatment of abscesses, asthma, rheumatism, and eye disease. Herein, we investigated the antiproliferative, cytotoxic effects and antibacterial activities of Fritillaria imperialis L. extracts on three cancer cell lines (HeLa, HT29, and C6), and a non-cancer cells (Vero). The potential antiproliferative and cytotoxic impact of Fritillaria imperialis L. extracts were investigated in vitro through MTT and LDH measurement techniques, and its antimicrobial effects were studied with MIC and disc-zone test. The extracts of Fritillaria imperialis L. have been shown to exhibit poor antiproliferative effects and antibacterial activities on some cancer cell lines and bacteria, respectively, at even high concentration. These data suggest that Fritillaria imperialis L. extracts are low cytotoxic to cancer cell lines and Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 25922). Our results indicate that clinic consideration of Fritillaria imperialis extracts for the treatment of malignant and bacterial disease needs to be re-evaluated due to its different extraction and isolation methods.

References

  • 1. World Cancer Report 2014. http://www.iarc.fr/en/publications/books/wcr/wcr-order.php (accessed 15.09.16).
  • 2. Elgorashi E. Screening of medicinal plants used in South African traditional medicine for genotoxic effects. Toxicol. Lett. 2003; 143, 195–207. doi:10.1016/S0378-4274(03)00176-0.
  • 3. Fennell CW, Lindsey KL, McGaw LJ, Sparg SG, Stafford GI, Elgorashi EE, Grace OM, van Staden J. Assessing African medicinal plants for efficacy and safety: pharmacological screening and toxicology. J. Ethnopharmacol. 2004; 94, 205–217.
  • 4. Sithranga Boopathy N, Kathiresan K. Anticancer Drugs from Marine Flora: An Overview. J. Oncol. 2010; 1–18. doi:10.1155/2010/214186.
  • 5. Weerapreeyakul N, Nonpunya A, Barusrux S, Thitimetharoch T, Sripanidkulchai B. Evaluation of the anticancer potential of six herbs against a hepatoma cell line Chin. Med. 2012; 7, 15.
  • 6. Lee CC, Houghton P. Cytotoxicity of plants from Malaysia and Thailand used traditionally to treat cancer. J. Ethnopharmacol. 2005; 100, 237–243.
  • 7. Berrington D, Lall N. Anticancer Activity of Certain Herbs and Spices on the Cervical Epithelial Carcinoma (HeLa) Cell Line. Evidence-Based Complement. Altern. Med. 2012; 1–11.
  • 8. Itharat A, Houghton PJ, Eno-Amooquaye E, Burke P, Sampson JH, Raman A. In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer. J. Ethnopharmacol. 2004; 90, 33–38.
  • 9. Chinese Pharmacopoeia Commission. http://www.chp.org.cn/cms/home/ (accessed 15.09.16).
  • 10. Shun-Wan C, Ping L, Yiu-Wa K, Ge L. In vitro Tracheobronchial Relaxation of Fritillaria Alkaloids. Chinese Journal of Natural Medicines. 2011; 9(5), 0345−0353. doi: 10.3724/SP.J.1009.2011.00345
  • 11. Kiani M, Sefidkon F, Babaei A, Naghavi MR. Phytochemical profiling of medicinal isosteroidal alkaloids of Iranian Fritillaria spp. (Liliaceae). Ind. Crops Prod. 2015; 70, 451–458.
  • 12. Atta-Ur-RahmaN, Akhtar MN, Choudhary MI, Tsuda Y, Sener B, Khalid A, Parvez M. New steroidal alkaloids from Fritillaria imperialis and their cholinesterase inhibiting activities. Chem. Pharm. Bull. 2002; 50, 1013–6.
  • 13. HAO D-C, GU X-J, XIAO P-G, PENG Y. Phytochemical and biological research of Fritillaria Medicine Resources. Chin. J. Nat. Med. 2013; 11, 330–344.
  • 14. Türktaş M, Aslay M, Kaya E, Ertuğrul F. Molecular characterization of phylogeneticrelationships in Fritillaria species inferred from chloroplast trnL-trnF sequences. Turk J Biol. 2012; 36, 552-560. doi:10.3906/biy-1201-30
  • 15. Maharjan BL, Devkota HK, Baral B. In-vitro Antimicrobial Activity and Phytochemical Screening of Fritillaria delavayi. Nepal J. Sci. Technol. 2012; 12, 85-90.
  • 16. Erbil N, Alan Y, Digrak M. Antimicrobial Activity of Different Vegetative Parts of Tulipa sintenisii (Mus Lalesi) and Fritillaria imperialis (Aglayan Gelin). International Journal of Scientific and Technological Research. 2015; 1(2), 120-127.
  • 17. Gilani AH, Shaheen F, Christopoulos A, Mitchelson F. Interaction of ebeinone, an alkaloid from Fritillaria imperialis, at two muscarinic acetylcholine receptor subtypes. Life Sci. 1997; 60(8), 535–44.
  • 18. Akhtar MN, Atta-ur-Rahman, Choudhary MI, Sener B, Erdogan I, Y. Tsuda Y. New class of steroidal alkaloids from Fritillaria imperialis. Phytochemistry 2003; 63(1), 115–122.
  • 19. Aydın A, Erenler R, Yılmaz B, Tekin Ş. Antiproliferative effect of Cherry laurel. JOTCSA, 2016; 3(3), 217-228.doi:10.18596/jotcsa.21204.
  • 20. Güler DA, Aydın A, Koyuncu M, Parmaksız İ. Anticancer Activity of Papaver somniferum L. JOTCSA, 2016; 3(3), 349-366. doi: 10.18596/jotcsa.43273
There are 20 citations in total.

Details

Primary Language English
Subjects Engineering, Chemical Engineering
Journal Section Articles
Authors

Ali Aydın 0000-0002-9550-9111

Emine Dede This is me

Mahfuz Elmastaş

Şaban Tekin This is me

Publication Date September 1, 2018
Submission Date April 25, 2017
Acceptance Date September 7, 2018
Published in Issue Year 2018 Volume: 5 Issue: 3

Cite

Vancouver Aydın A, Dede E, Elmastaş M, Tekin Ş. Biological Property of Fritillaria imperialis L. Extract. JOTCSA. 2018;5(3):1043-50.