Biochemical Confirmation of Anti-Inflammatory Activity of Oxicam-Based Pharmaceutical Compositions

Year 2018, Volume: 5 Issue: 3, 1407 - 1412, 01.09.2018

Ganna Syrova Tetyana Tishakova , Olga Levashova Olena Savelieva

https://doi.org/10.18596/jotcsa.463663

Cited By: 2

Abstract

Biochemical
confirmation of anti-inflammatory activity of oxicam-based pharmaceutical
compositions was performed by the determination of the level of one of the main
markers of inflammation-C-reactive protein. Biochemical studies were carried
out on laboratory animals (white WAG rats) to study the anti-inflammatory
effects of meloxicam, piroxicam, caffeine, and
pharmaceutical compositions consisting of meloxicam and caffeine, piroxicam and
caffeine compared to the reference drug - sodium diclofenac. The content of CRP
in serum of rats was determined using the CRP latex test kit (State
registration number 1248/2002, Kharkiv, Ukraine). It was shown that composition of meloxicam and caffeine reduced the
content of CRP by 16 times compared with formalin-induced
edema, and by 2 times in comparison with the reference drug diclofenac sodium, which is statistically
significantly different from the control, i.e. caffeine increases and potentiates anti-inflammatory action of
meloxicam.

Keywords

anti-inflammatory activity, parmaceutical composition

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