Study on the preparation and drug release property of Modified PEG-DA based hydrogels

Year 2019, Volume: 6 Issue: 1, 1 - 14, 15.05.2019

Şebnem Şenol Emel Akyol

https://doi.org/10.18596/jotcsa.485817

Cited By: 3

Abstract

The aim of the present study is to
develop hydroxyapatite modified PEG-DA and PEG-DA/HEMA based hydrogels for
release of Donepezil HCl for potential treatment of Alzheimer’s disease.
[2,2-Dimethoxy-2-phenyl-acetophenone] (Irgacure 651),  1 Hydroxycyclohexyl phenyl ketone (Irgacure
184) and 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (Irgacure
2959)  were used as photo-initiators in
the synthesis of hydrogels and 
hydroxyapatite was used for modifying hydrogels. Fourier transform
infrared spectroscopy (FT-IR), scanning electron microscope (SEM) and digital
microscope were utilized to investigate the characteristics properties of hydrogels.
Photopolymerization technique was selected to synthesize for hydrogels.  Swelling and drug release studies have been
performed under different pH conditions.

Keywords

Hydrogels, Photopolymerization, Donepezil HCl, Polyethylene diacyrlate, Alzheimer's Disease

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